Yu Q - Search Results

1

A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase.

Greig NH, Utsuki T, Yu Q, Zhu X, Holloway HW, Perry T, Lee B, Ingram DK, Lahiri DK. Greig NH, et al. Among authors: yu q. Curr Med Res Opin. 2001;17(3):159-65. doi: 10.1185/0300799039117057. Curr Med Res Opin. 2001. PMID: 11900310 Review.

2

Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.

Yu Q, Holloway HW, Utsuki T, Brossi A, Greig NH. Yu Q, et al. J Med Chem. 1999 May 20;42(10):1855-61. doi: 10.1021/jm980459s. J Med Chem. 1999. PMID: 10346939

Four novel analogues (8-11) of cymserine (2) were synthesized by methods similar to those recently developed for the total syntheses of N8-norphenserine (Yu, Q. S.; et al. J. Med. Chem. 1997, 40, 2895-2901) and N1,N8-bisnorphenserine (Yu, Q. ...

Four novel analogues (8-11) of cymserine (2) were synthesized by methods similar to those recently developed for the total syntheses of N8-n …

3

Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.

Yu Q, Holloway HW, Flippen-Anderson JL, Hoffman B, Brossi A, Greig NH. Yu Q, et al. J Med Chem. 2001 Nov 22;44(24):4062-71. doi: 10.1021/jm010080x. J Med Chem. 2001. PMID: 11708910

4

The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics.

Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Perry TA, Brossi A, Ingram DK, Deutsch J, Lahiri DK, Soncrant TT. Greig NH, et al. Among authors: yu qs. Acta Neurol Scand Suppl. 2000;176:74-84. doi: 10.1034/j.1600-0404.2000.00311.x. Acta Neurol Scand Suppl. 2000. PMID: 11261809

5

Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.

Yu QS, Pei XF, Holloway HW, Greig NH, Brossi A. Yu QS, et al. J Med Chem. 1997 Aug 29;40(18):2895-901. doi: 10.1021/jm970210v. J Med Chem. 1997. PMID: 9288171

6

Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor.

Patel N, Spangler EL, Greig NH, Yu QS, Ingram DK, Meyer RC. Patel N, et al. Among authors: yu qs. Neuroreport. 1998 Jan 5;9(1):171-6. doi: 10.1097/00001756-199801050-00035. Neuroreport. 1998. PMID: 9592071

7

Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans.

Carmona GN, Jufer RA, Goldberg SR, Gorelick DA, Greig NH, Yu QS, Cone EJ, Schindler CW. Carmona GN, et al. Among authors: yu qs. Drug Metab Dispos. 2000 Mar;28(3):367-71. Drug Metab Dispos. 2000. PMID: 10681384

8

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, Greig NH, Mattson MP. Culmsee C, et al. Among authors: yu qs. J Neurochem. 2001 Apr;77(1):220-8. doi: 10.1046/j.1471-4159.2001.t01-1-00220.x. J Neurochem. 2001. PMID: 11279278 Free article.

9

Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.

Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH. Shaw KT, et al. Among authors: yu qs. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7605-10. doi: 10.1073/pnas.131152998. Epub 2001 Jun 12. Proc Natl Acad Sci U S A. 2001. PMID: 11404470 Free PMC article.

10

Syntheses and anticholinesterase activities of (3aS)-N1, N8-bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine.

Yu Q, Greig NH, Holloway HW, Brossi A. Yu Q, et al. J Med Chem. 1998 Jun 18;41(13):2371-9. doi: 10.1021/jm9800494. J Med Chem. 1998. PMID: 9632370

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