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Page 1
Dyskeratosis Congenita and Related Telomere Biology Disorders.
Savage SA, Niewisch MR. Savage SA, et al. 2009 Nov 12 [updated 2023 Jan 19]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2009 Nov 12 [updated 2023 Jan 19]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301779 Free Books & Documents. Review.
Hematopoietic cell transplantation (HCT) is the only curative treatment for BMF and leukemia, but long-term outcome has historically been poor due to treatment toxicity; if a suitable donor is not available, androgen therapy may be considered for BMF. Treatment of other cancer …
Hematopoietic cell transplantation (HCT) is the only curative treatment for BMF and leukemia, but long-term outcome has historically been po …
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Puno MR, Lima CD. Puno MR, et al. Cell. 2022 Jun 9;185(12):2132-2147.e26. doi: 10.1016/j.cell.2022.04.016. Cell. 2022. PMID: 35688134 Free PMC article.
All three subunits collaborate to bind the RNA, with RBM7 and ZCCHC8 surveying sequences upstream of the 3' end to facilitate RNA capture by MTR4. ZCCHC8 obscures MTR4 surfaces important for RNA binding and extrusion as well as MPP6-dependent recruitment and docking …
All three subunits collaborate to bind the RNA, with RBM7 and ZCCHC8 surveying sequences upstream of the 3' end to facilitate RNA cap …
Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.
Gianno F, Giovannoni I, Cafferata B, Diomedi-Camassei F, Minasi S, Barresi S, Buttarelli FR, Alesi V, Cardoni A, Antonelli M, Puggioni C, Colafati GS, Carai A, Vinci M, Mastronuzzi A, Miele E, Alaggio R, Giangaspero F, Rossi S. Gianno F, et al. Pathologica. 2022 Dec;114(6):422-435. doi: 10.32074/1591-951X-830. Pathologica. 2022. PMID: 36534421 Free PMC article. Review.
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression.
Garland W, Müller I, Wu M, Schmid M, Imamura K, Rib L, Sandelin A, Helin K, Jensen TH. Garland W, et al. Mol Cell. 2022 May 5;82(9):1691-1707.e8. doi: 10.1016/j.molcel.2022.03.004. Epub 2022 Mar 28. Mol Cell. 2022. PMID: 35349793 Free PMC article.
Here, we describe a functional connection between the mouse-orthologous "nuclear exosome targeting" (NEXT) and "human silencing hub" (HUSH) complexes, involved in nuclear RNA decay and the epigenetic silencing of TEs, respectively. Knocking out the NEXT component ZCCHC8 in …
Here, we describe a functional connection between the mouse-orthologous "nuclear exosome targeting" (NEXT) and "human silencing hub" (HUSH) …
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
Gable DL, Gaysinskaya V, Atik CC, Talbot CC Jr, Kang B, Stanley SE, Pugh EW, Amat-Codina N, Schenk KM, Arcasoy MO, Brayton C, Florea L, Armanios M. Gable DL, et al. Genes Dev. 2019 Oct 1;33(19-20):1381-1396. doi: 10.1101/gad.326785.119. Epub 2019 Sep 5. Genes Dev. 2019. PMID: 31488579 Free PMC article.
ZCCHC8 associated with TR and was required for telomerase function. In ZCCHC8 knockout cells and in mutation carriers, genomically extended telomerase RNA (TR) accumulated at the expense of mature TR, consistent with a role for ZCCHC8 in mediating TR 3' end t …
ZCCHC8 associated with TR and was required for telomerase function. In ZCCHC8 knockout cells and in mutation carriers, genomic …
Modeling Spitz melanoma in zebrafish using sequential mutagenesis.
Mito JK, Weber MC, Corbin A, Murphy GF, Zon LI. Mito JK, et al. Dis Model Mech. 2022 Aug 1;15(8):dmm049452. doi: 10.1242/dmm.049452. Epub 2022 Aug 26. Dis Model Mech. 2022. PMID: 36017742 Free PMC article.
By 7 weeks, ZCCHC8-ROS1 induced a histologic spectrum of neoplasms ranging from hyperpigmented patches to melanoma. ...Our model exhibits the use of sequential mutagenesis in the adult zebrafish, and demonstrates that ZCCHC8-ROS1 induces a spectrum of melanoc …
By 7 weeks, ZCCHC8-ROS1 induced a histologic spectrum of neoplasms ranging from hyperpigmented patches to melanoma. ...Our mod …
Identification of tumor antigens and immune landscapes for bladder urothelial carcinoma mRNA vaccine.
Sun Z, Jing C, Zhan H, Guo X, Suo N, Kong F, Tao W, Xiao C, Hu D, Wang H, Jiang S. Sun Z, et al. Front Immunol. 2023 Jan 25;14:1097472. doi: 10.3389/fimmu.2023.1097472. eCollection 2023. Front Immunol. 2023. PMID: 36761744 Free PMC article.
METHODS: Gene expression microarray data and clinical information were retrieved from The Cancer Genome Atlas and GSE32894, respectively. The mRNA splicing patterns were obtained from the SpliceSeq portal. The cBioPortal for Cancer Genomics was used to visualize gen …
METHODS: Gene expression microarray data and clinical information were retrieved from The Cancer Genome Atlas and GSE32894, respectiv …
Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins.
Gustafson MP, Welcker M, Hwang HC, Clurman BE. Gustafson MP, et al. Biochem Biophys Res Commun. 2005 Dec 23;338(3):1359-67. doi: 10.1016/j.bbrc.2005.10.090. Epub 2005 Oct 25. Biochem Biophys Res Commun. 2005. PMID: 16263084
We show that Zcchc8 is directly phosphorylated by GSK-3 in vitro and that GSK-3 inhibition prevents Zcchc8 phosphorylation in vivo. ...We suggest that Zcchc8 is a GSK-3 substrate with a role in RNA metabolism....
We show that Zcchc8 is directly phosphorylated by GSK-3 in vitro and that GSK-3 inhibition prevents Zcchc8 phosphorylation in …
Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3).
Coccé MC, Mardin BR, Bens S, Stütz AM, Lubieniecki F, Vater I, Korbel JO, Siebert R, Alonso CN, Gallego MS. Coccé MC, et al. Genes Chromosomes Cancer. 2016 Sep;55(9):677-87. doi: 10.1002/gcc.22369. Epub 2016 Jun 23. Genes Chromosomes Cancer. 2016. PMID: 27121553
By sequencing, the translocation was shown to form a fusion between the 5' region of ZCCHC8 and the 3' region of ROS1. RT-PCR analyses confirmed the existence of an in-frame fusion transcript with ZCCHC8 exons 1-3 joined to ROS1 exons 36-43. In addition to the ZC …
By sequencing, the translocation was shown to form a fusion between the 5' region of ZCCHC8 and the 3' region of ROS1. RT-PCR analyse …
20 results