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Page 1
Caveolin-2 palmitoylation turnover facilitates insulin receptor substrate-1-directed lipid metabolism by insulin receptor tyrosine kinase.
Choi M, Lee J, Jeong K, Pak Y. Choi M, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 16;1870(5):167173. doi: 10.1016/j.bbadis.2024.167173. Online ahead of print. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38631410
Acyl protein thioesterases-1 (APT1) catalyzes Cav-2 depalmitoylation, and zinc finger DHHC domain-containing protein palmitoyltransferase 21 (ZDHHC21) repalmitoylation of the depalmitoylated Cav-2 for the turnover, thereby controlling insulin receptor (IR)-Cav-2-insulin re …
Acyl protein thioesterases-1 (APT1) catalyzes Cav-2 depalmitoylation, and zinc finger DHHC domain-containing protein palmitoyltransferase 21 …
Acylation of MLKL Impacts Its Function in Necroptosis.
Pradhan AJ, Chitkara S, Ramirez RX, Monje-Galvan V, Sancak Y, Atilla-Gokcumen GE. Pradhan AJ, et al. ACS Chem Biol. 2024 Feb 16;19(2):407-418. doi: 10.1021/acschembio.3c00603. Epub 2024 Feb 1. ACS Chem Biol. 2024. PMID: 38301282
Through investigations of the S-palmitoyltransferases that might acylate pMLKL in necroptosis, we showed that zDHHC21 activity has the strongest effect on pMLKL acylation, inactivation of which profoundly reduced the pMLKL levels in cells and improved membrane integrity. . …
Through investigations of the S-palmitoyltransferases that might acylate pMLKL in necroptosis, we showed that zDHHC21 activity has th …
Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma.
Liu B, Zhao X, Zhang S, Li Q, Li X, Huang D, Xia J, Ma N, Duan Y, Zhang X, Rao J. Liu B, et al. Leukemia. 2024 Feb;38(2):351-364. doi: 10.1038/s41375-023-02130-5. Epub 2024 Jan 9. Leukemia. 2024. PMID: 38195819 Free PMC article.
In this study, we uncovered a novel function of the palmitoyltransferase ZDHHC21 as a tumor suppressor in DLBCL and identified ZDHHC21 as a key regulator of fatty acid synthetase (FASN) S-palmitoylation for the first time. ...Our results demonstrate that ZDHHC21 …
In this study, we uncovered a novel function of the palmitoyltransferase ZDHHC21 as a tumor suppressor in DLBCL and identified ZDH …
Acylation of MLKL impacts its function in necroptosis.
Pradhan AJ, Chitkara S, Ramirez RX, Monje-Galvan V, Sancak Y, Ekin Atilla-Gokcumen G. Pradhan AJ, et al. bioRxiv [Preprint]. 2023 Nov 2:2023.08.19.553906. doi: 10.1101/2023.08.19.553906. bioRxiv. 2023. PMID: 37645912 Free PMC article. Updated. Preprint.
Through systematic investigations of the S-palmitoyltransferases that might acylate MLKL in necroptosis, we showed that zDHHC21 activity has the strongest effect on pMLKL acylation, inactivation of which profoundly reduced the pMLKL levels in cells and improved membrane in …
Through systematic investigations of the S-palmitoyltransferases that might acylate MLKL in necroptosis, we showed that zDHHC21 activ …
Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer's disease.
Li W, Pang Y, Wang Y, Mei F, Guo M, Wei Y, Li X, Qin W, Wang W, Jia L, Jia J. Li W, et al. BMC Med. 2023 Jun 26;21(1):223. doi: 10.1186/s12916-023-02930-7. BMC Med. 2023. PMID: 37365538 Free PMC article.
METHODS: We performed exome sequencing on family members with a FAD pedigree and identified gene variant ZDHHC21 p.T209S. A ZDHHC21(T209S/T209S) knock-in mouse model was then generated using CRISPR/Cas9. ...The palmitoylation of APP was also increased in ZDHHC21 …
METHODS: We performed exome sequencing on family members with a FAD pedigree and identified gene variant ZDHHC21 p.T209S. A ZDHHC2 …
The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
Shao X, Xu A, Du W, Xu T, Huang Y, Xia Z, Wang W, Cai M, Zhang X, Zhang J, Cao J, Xu X, Yang B, He Q, Ying M. Shao X, et al. Blood. 2023 Jul 27;142(4):365-381. doi: 10.1182/blood.2022019056. Blood. 2023. PMID: 37216691
Interestingly, FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD)-mutated AML cells expressed significantly higher levels of ZDHHC21 and exhibited better sensitivity to ZDHHC21 inhibition. Mechanistically, ZDHHC21 specifically catalyzed the pal …
Interestingly, FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD)-mutated AML cells expressed significantly higher levels of …
Protein palmitoylation regulates extracellular vesicle production and function in sepsis.
Yang X, Zheng E, Chatterjee V, Ma Y, Reynolds A, Villalba N, Wu MH, Yuan SY. Yang X, et al. J Extracell Biol. 2022 Jul;1(7):e50. doi: 10.1002/jex2.50. Epub 2022 Jul 5. J Extracell Biol. 2022. PMID: 38419739 Free PMC article.
Furthermore, WT and Zdhhc21(dep/dep) EVs displayed distinct palmitoyl-proteomic profiles. ...Furthermore, Zdhhc21(dep/dep) mice displayed reduced neutrophil infiltration in lungs and improved survival after CLP challenges. ...
Furthermore, WT and Zdhhc21(dep/dep) EVs displayed distinct palmitoyl-proteomic profiles. ...Furthermore, Zdhhc21(dep/dep) mic …
Gene network analysis reveals candidate genes related with the hair follicle development in sheep.
He J, Zhao B, Huang X, Fu X, Liu G, Tian Y, Wu C, Mao J, Liu J, Gun S, Tian K. He J, et al. BMC Genomics. 2022 Jun 8;23(1):428. doi: 10.1186/s12864-022-08552-2. BMC Genomics. 2022. PMID: 35672687 Free PMC article.
DEGs with stage-specific expression were significantly enriched in epidermal differentiation and development, hair follicle development and hair follicle morphogenesis and were enriched in many pathways related to hair follicle development. The key genes (LAMA5, WNT10A, KRT25, SO …
DEGs with stage-specific expression were significantly enriched in epidermal differentiation and development, hair follicle development and …
Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma cancer.
Liu R, Hu Y, Liu T, Wang Y. Liu R, et al. BMC Cancer. 2021 Dec 18;21(1):1345. doi: 10.1186/s12885-021-09042-6. BMC Cancer. 2021. PMID: 34922489 Free PMC article.
From that, we identified nine genes with different levels in immune cell infiltration related to osteosarcoma, eight of which including SORBS2, BAIAP2L2, ATAD2, CYGB, PAMR1, PSIP1, SNAPC3 and ZDHHC21 in their low abundance have higher disease-free survival probability than …
From that, we identified nine genes with different levels in immune cell infiltration related to osteosarcoma, eight of which including SORB …
23 results