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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heijer M, Hollander AI, Ruijter HM, Dennis JG, Denny JC, Di Angelantonio E, Drenos F, Du M, Dubé MP, Dunning AM, Easton DF, Edwards TL, Ellinghaus D, Ellinor PT, Elliott P, Evange… See abstract for full author list ➔ Turcot V, et al. Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. Epub 2017 Dec 22. Nat Genet. 2018. PMID: 29273807 Free PMC article.
We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity a …
We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 an …
Genomic characterization of cervical cancer based on human papillomavirus status.
Zhang L, Jiang Y, Lu X, Zhao H, Chen C, Wang Y, Hu W, Zhu Y, Yan H, Yan F. Zhang L, et al. Gynecol Oncol. 2019 Mar;152(3):629-637. doi: 10.1016/j.ygyno.2018.12.017. Epub 2018 Dec 20. Gynecol Oncol. 2019. PMID: 30581036
OBJECTIVE: It is uncommon for cervical cancer patients to be diagnosed without a human papillomavirus (HPV) infection. ...Gene expression profiles of HPV+ and HPV- tumors differed especially in ANKRD7, SERPINB3, EMX2, MEI1, RNF212, RP11-13 K12.5, RP11-325F22.2 and ZFR2 …
OBJECTIVE: It is uncommon for cervical cancer patients to be diagnosed without a human papillomavirus (HPV) infection. ...Gene expres …
DNA methylation profiles in African American prostate cancer patients in relation to disease progression.
Rubicz R, Zhao S, Geybels M, Wright JL, Kolb S, Klotzle B, Bibikova M, Troyer D, Lance R, Ostrander EA, Feng Z, Fan JB, Stanford JL. Rubicz R, et al. Genomics. 2019 Jan;111(1):10-16. doi: 10.1016/j.ygeno.2016.02.004. Epub 2016 Feb 21. Genomics. 2019. PMID: 26902887 Free PMC article.
This study examined whether differential DNA methylation is associated with clinical features of more aggressive disease at diagnosis and prostate cancer recurrence in African American men, who are more likely to die from prostate cancer than other populations. ...L …
This study examined whether differential DNA methylation is associated with clinical features of more aggressive disease at diagnosis and pr …
Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers.
Mandić K, Milutin Gašperov N, Božinović K, Dediol E, Krasić J, Sinčić N, Grce M, Sabol I, Barešić A. Mandić K, et al. Sci Rep. 2024 Apr 20;14(1):9062. doi: 10.1038/s41598-024-59312-z. Sci Rep. 2024. PMID: 38643268 Free PMC article.
Infection with HPV is a well known aetiology, which affects the nature of these cancers and patients' survival. Besides, it is considered that the main driving force for this type of cancer could be epigenetics. ...For the integrative analysis we performed kmeans cl …
Infection with HPV is a well known aetiology, which affects the nature of these cancers and patients' survival. Besides, it is consid …
Human papillomavirus elevated genetic biomarker signature by statistical algorithm.
Tripathi N, Keshari S, Shahi P, Maurya P, Bhattacharjee A, Gupta K, Talole S, Kumar M. Tripathi N, et al. J Cell Physiol. 2020 Dec;235(12):9922-9932. doi: 10.1002/jcp.29807. Epub 2020 Jun 14. J Cell Physiol. 2020. PMID: 32537823

We found that among these 11 genes, nine genes, CCNA1, MMP3, FLRT3, GJB6, ZFR2, PITX2, SYCP2, MEI1, and UGT8 were significant (p < .05). A survival plot was drawn between the p value and gene expression. ...Finally, we found the biomarker index for relapse time and risk

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We found that among these 11 genes, nine genes, CCNA1, MMP3, FLRT3, GJB6, ZFR2, PITX2, SYCP2, MEI1, and UGT8 were significant (p < …
Identification and in vitro characterization of phage-displayed VHHs targeting VEGF.
Farajpour Z, Rahbarizadeh F, Kazemi B, Ahmadvand D, Mohaghegh M. Farajpour Z, et al. J Biomol Screen. 2014 Apr;19(4):547-55. doi: 10.1177/1087057113514275. Epub 2013 Dec 2. J Biomol Screen. 2014. PMID: 24297044
Vascular endothelial growth factor (VEGF) is a potential target for cancer treatment because of its role in angiogenesis and its overexpression in most human cancers. ...Taken together, our results indicate that ZFR-5 and other VHHs may be promising tools in canc …
Vascular endothelial growth factor (VEGF) is a potential target for cancer treatment because of its role in angiogenesis and its over …