Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2010 1
2011 1
2013 1
2015 1
2016 2
2017 1
2018 3
2019 2
2020 9
2021 5
2022 5
2023 2
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

32 results

Results by year

Filters applied: . Clear all
Page 1
ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer.
Meng H, Ding Y, Liu E, Li W, Wang L. Meng H, et al. Transl Oncol. 2021 Feb;14(2):101003. doi: 10.1016/j.tranon.2020.101003. Epub 2020 Dec 25. Transl Oncol. 2021. PMID: 33360840 Free PMC article.
Besides, ZG16 is negatively correlated to PD-L1 expression in patient with CRC and overexpression of ZG16 blocks PD-L1 expression in colorectal cancer cells. ...Our data demonstrate that ZG16 plays a role in modulation of immune response in colorectal …
Besides, ZG16 is negatively correlated to PD-L1 expression in patient with CRC and overexpression of ZG16 blocks PD-L1 express …
ZG16 promotes T-cell mediated immunity through direct binding to PD-L1 in colon cancer.
Meng H, Yao W, Yin Y, Li Y, Ding Y, Wang L, Zhang M. Meng H, et al. Biomark Res. 2022 Jul 13;10(1):47. doi: 10.1186/s40364-022-00396-y. Biomark Res. 2022. PMID: 35831911 Free PMC article.
We previously showed a negative correlation of zymogen granule protein 16 (ZG16) with programmed death-ligand 1 (PD-L1) expression in patients with colorectal cancer. ...Mutations on the lectin domain of ZG16 largely inhibit the interaction between ZG16 …
We previously showed a negative correlation of zymogen granule protein 16 (ZG16) with programmed death-ligand 1 (PD-L1) expression in …
Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
Javitt G, Kinzel A, Reznik N, Fass D. Javitt G, et al. FEBS J. 2021 Nov;288(22):6465-6475. doi: 10.1111/febs.16044. Epub 2021 Jun 15. FEBS J. 2021. PMID: 34077620 Free PMC article.
ZG16 binds microbial pathogens, and lower ZG16 expression levels correlate with colorectal cancer, but the physiological function of the protein is poorly understood. ...Specifically, we demonstrate that the ZG16 cysteine thiols can be oxidized to a di …
ZG16 binds microbial pathogens, and lower ZG16 expression levels correlate with colorectal cancer, but the physiologica …
Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer.
Meng H, Li W, Boardman LA, Wang L. Meng H, et al. BMC Cancer. 2018 Apr 16;18(1):433. doi: 10.1186/s12885-018-4337-2. BMC Cancer. 2018. PMID: 29661177 Free PMC article.
BACKGROUND: Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. ...Association with multiple clinicopathological features indicates that ZG16 may play an important role in cancer i …
BACKGROUND: Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) …
Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer.
Chen X, Du P, She J, Cao L, Li Y, Xia H. Chen X, et al. Oncotarget. 2016 Dec 27;7(52):86695-86703. doi: 10.18632/oncotarget.13435. Oncotarget. 2016. PMID: 27880730 Free PMC article.
Colorectal cancer (CRC) is one of the most common malignant tumour and the leading cause of cancer-related mortality worldwide. ...Interestingly, the expression of ZG16 was negatively correlated with CRC stem cell marker, LGR5. Overexpression of ZG16 s …
Colorectal cancer (CRC) is one of the most common malignant tumour and the leading cause of cancer-related mortality worldwide …
A Novel Prognostic Score Based on ZG16 for Predicting CRC Survival.
Wang W, Sun JF, Wang XZ, Ying HQ, You XH, Sun F. Wang W, et al. Pharmgenomics Pers Med. 2020 Dec 16;13:735-747. doi: 10.2147/PGPM.S275941. eCollection 2020. Pharmgenomics Pers Med. 2020. PMID: 33364813 Free PMC article.
After, the protein-protein interaction (PPI) network was constructed and 15 hub genes including ZG16 were identified. The differential expression of ZG16 between tumor and normal colorectal tissues were further verified in GEPIA and HAP database. ...Furthermore, a c …
After, the protein-protein interaction (PPI) network was constructed and 15 hub genes including ZG16 were identified. The differentia …
Circulating Tumor Cells and Breast Cancer Metastasis: From Enumeration to Somatic Mutational Profile.
Zhu C, Xu J, Sun J, Cui S, Sun Y, Yu T, Wang C, Wang T, Wu Y, Ju F, Yao J, Liu K, Zhang W, Guan X. Zhu C, et al. J Clin Med. 2022 Oct 14;11(20):6067. doi: 10.3390/jcm11206067. J Clin Med. 2022. PMID: 36294386 Free PMC article.
Aims: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. Methods: A retrospective study was conducted using patients with histologically confirmed breast cancer recruited from the First Affiliated Hospital of …
Aims: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. Methods: A retrosp …
DNAH7 mutations benefit colorectal cancer patients receiving immune checkpoint inhibitors.
Yang W, Shen Z, Yang T, Wu M. Yang W, et al. Ann Transl Med. 2022 Dec;10(24):1335. doi: 10.21037/atm-22-6166. Ann Transl Med. 2022. PMID: 36660654 Free PMC article.
BACKGROUND: Colorectal cancer (CRC) is a malignant tumor associated with a high mortality rate. ...METHODS: A clinical cohort (n=690) and the CRC data from the publicly available Cancer Genome Atlas (TCGA) were examined. Gene Set Enrichment Analysis, ESTIMATE analys …
BACKGROUND: Colorectal cancer (CRC) is a malignant tumor associated with a high mortality rate. ...METHODS: A clinical cohort (n=690) …
MiR-196: emerging of a new potential therapeutic target and biomarker in colorectal cancer.
Pourdavoud P, Pakzad B, Mosallaei M, Saadatian Z, Esmaeilzadeh E, Alimolaie A, Shaygannejad A. Pourdavoud P, et al. Mol Biol Rep. 2020 Dec;47(12):9913-9920. doi: 10.1007/s11033-020-05949-8. Epub 2020 Nov 1. Mol Biol Rep. 2020. PMID: 33130965 Review.
Deregulation of microRNAs, as key elements in colorectal cancer (CRC) pathogenesis, is correlated with various stages of this cancer. miR-196 is involved in the initiation and progression of a verity of malignances, especially CRC. miR-196 in CRC cells could target …
Deregulation of microRNAs, as key elements in colorectal cancer (CRC) pathogenesis, is correlated with various stages of this canc …
Identification of hub genes in colon cancer via bioinformatics analysis.
Liu J, Sun GL, Pan SL, Qin MB, Ouyang R, Huang JA. Liu J, et al. J Int Med Res. 2020 Sep;48(9):300060520953234. doi: 10.1177/0300060520953234. J Int Med Res. 2020. PMID: 32961078 Free PMC article.
TIMP1 and BGN were upregulated in patients with a high cancer risk, whereas ZG16 was downregulated. The immunostaining results from HPA supported these findings. CONCLUSION: This study indicates that these hub genes may be promising prognostic indicators or therapeu …
TIMP1 and BGN were upregulated in patients with a high cancer risk, whereas ZG16 was downregulated. The immunostaining results …
32 results