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LncRNA IGBP1-AS1/miR-24-1/ZIC3 loop regulates the proliferation and invasion ability in breast cancer.
Chen D, Fan Y, Wan F. Chen D, et al. Cancer Cell Int. 2020 May 7;20:153. doi: 10.1186/s12935-020-01214-x. eCollection 2020. Cancer Cell Int. 2020. PMID: 32390766 Free PMC article.
BACKGROUND: Breast cancer (BC) is one of the malignant solid tumors with the highest morbidity in the world. ...Analysis of the samples obtained from BC patients indicated a positive effect of IGBP1-AS1 on survival outcomes. LncRNA IGBP1-AS1/miR-24-1/ZIC3 axis as a …
BACKGROUND: Breast cancer (BC) is one of the malignant solid tumors with the highest morbidity in the world. ...Analysis of the sampl …
MiR-564 functions as a tumor suppressor in human lung cancer by targeting ZIC3.
Yang B, Jia L, Guo Q, Ren H, Hu D, Zhou X, Ren Q, Hu Y, Xie T. Yang B, et al. Biochem Biophys Res Commun. 2015 Nov 27;467(4):690-6. doi: 10.1016/j.bbrc.2015.10.082. Epub 2015 Oct 21. Biochem Biophys Res Commun. 2015. PMID: 26498524
In the present study, we found that miR-564 frequently downregulated in lung cancer cells and significantly inhibited cell proliferation, cell cycle progression, motility, and the tumorigenicity of lung cancer cells. Moreover, we identified zic family member 3 (Z …
In the present study, we found that miR-564 frequently downregulated in lung cancer cells and significantly inhibited cell proliferat …
Zic3 enhances the generation of mouse induced pluripotent stem cells.
Declercq J, Sheshadri P, Verfaillie CM, Kumar A. Declercq J, et al. Stem Cells Dev. 2013 Jul 15;22(14):2017-25. doi: 10.1089/scd.2012.0651. Epub 2013 Mar 28. Stem Cells Dev. 2013. PMID: 23421367 Free PMC article.
Not only does Zic3 enhance the reprogramming efficiency, but also reactivation of the endogenous Zic3 protein is essential for the generation of iPSCs, as knockdown of Zic3 during the iPSC generation with OSKM significantly reduced the number of colonies. Tog …
Not only does Zic3 enhance the reprogramming efficiency, but also reactivation of the endogenous Zic3 protein is essential for …
Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.
Lin X, Swedlund B, Ton MN, Ghazanfar S, Guibentif C, Paulissen C, Baudelet E, Plaindoux E, Achouri Y, Calonne E, Dubois C, Mansfield W, Zaffran S, Marioni JC, Fuks F, Göttgens B, Lescroart F, Blanpain C. Lin X, et al. Nat Cell Biol. 2022 Jul;24(7):1114-1128. doi: 10.1038/s41556-022-00947-3. Epub 2022 Jul 11. Nat Cell Biol. 2022. PMID: 35817961 Free PMC article.
We identified different enhancers that are temporally regulated to erase the pluripotent state and specify the pools of CPs that mediate heart development. We identified Zic2 and Zic3 as essential cofactors that act with Mesp1 to regulate its transcription-factor activity …
We identified different enhancers that are temporally regulated to erase the pluripotent state and specify the pools of CPs that mediate hea …
Developmental regulation of barrier- and non-barrier blood vessels in the CNS.
Ben-Zvi A, Liebner S. Ben-Zvi A, et al. J Intern Med. 2022 Jul;292(1):31-46. doi: 10.1111/joim.13263. Epub 2021 Mar 4. J Intern Med. 2022. PMID: 33665890 Review.
We discuss recent insights into the downstream molecular mechanisms of Wnt/beta-catenin in particular, the recently identified target genes like Foxf2, Foxl2, Foxq1, Lef1, Ppard, Zfp551, Zic3, Sox17, Apcdd1 and Fgfbp1 that are involved in refining and maintaining barrier c …
We discuss recent insights into the downstream molecular mechanisms of Wnt/beta-catenin in particular, the recently identified target genes …
Human-gained heart enhancers are associated with species-specific cardiac attributes.
Destici E, Zhu F, Tran S, Preissl S, Farah EN, Zhang Y, Hou X, Poirion OB, Lee AY, Grinstein JD, Bloomekatz J, Kim HS, Hu R, Evans SM, Ren B, Benner C, Chi NC. Destici E, et al. Nat Cardiovasc Res. 2022 Sep;1(9):830-843. doi: 10.1038/s44161-022-00124-7. Epub 2022 Sep 15. Nat Cardiovasc Res. 2022. PMID: 36817700 Free PMC article.
In particular, we discovered that gained enhancers in the locus of the early human developmental regulator ZIC3 are selectively accessible within a subpopulation of mesoderm cells which exhibits cardiogenic potential, thus possibly extending the function of ZIC3 bey …
In particular, we discovered that gained enhancers in the locus of the early human developmental regulator ZIC3 are selectively acces …
Engrailed 1 overexpression as a potential prognostic marker in quintuple-negative breast cancer.
Kim YJ, Sung M, Oh E, Vrancken MV, Song JY, Jung K, Choi YL. Kim YJ, et al. Cancer Biol Ther. 2018 Apr 3;19(4):335-345. doi: 10.1080/15384047.2018.1423913. Epub 2018 Feb 13. Cancer Biol Ther. 2018. PMID: 29333926 Free PMC article.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by poor patient prognosis and for which no targeted therapies are currently available. ...We found that Engrailed 1 (EN1) was significantly overexpressed in TNBC. Using breast …
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by poor patient prognosis and for wh …
Roles of ZIC family genes in human gastric cancer.
Ma G, Dai W, Sang A, Yang X, Li Q. Ma G, et al. Int J Mol Med. 2016 Jul;38(1):259-66. doi: 10.3892/ijmm.2016.2587. Epub 2016 May 12. Int J Mol Med. 2016. PMID: 27177248
The human zinc finger of the cerebellum (ZIC)family genes, comprised of 5 members, which are vertebrate homologues of the Drosophila odd-paired gene and encode zinc-finger transcription factors, have been shown to be involved in various diseases, including cancer. However, …
The human zinc finger of the cerebellum (ZIC)family genes, comprised of 5 members, which are vertebrate homologues of the Drosophila odd-pai …
Rapid response of stage IV colorectal cancer with APC/TP53/KRAS mutations to FOLFIRI and Bevacizumab combination chemotherapy: a case report of use of liquid biopsy.
Hendricks A, Rosenstiel P, Hinz S, Burmeister G, Röcken C, Boersch K, Schafmayer C, Becker T, Franke A, Forster M. Hendricks A, et al. BMC Med Genet. 2020 Jan 3;21(1):3. doi: 10.1186/s12881-019-0941-5. BMC Med Genet. 2020. PMID: 31900123 Free PMC article.
BACKGROUND: Liquid biopsies of blood plasma cell free DNA can be used to monitor treatment response and potentially detect mutations that are present in resistant clones in metastatic cancer patients. CASE PRESENTATION: In our non-interventional liquid biopsy study, a male …
BACKGROUND: Liquid biopsies of blood plasma cell free DNA can be used to monitor treatment response and potentially detect mutations that ar …
Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association.
Hilger AC, Halbritter J, Pennimpede T, van der Ven A, Sarma G, Braun DA, Porath JD, Kohl S, Hwang DY, Dworschak GC, Hermann BG, Pavlova A, El-Maarri O, Nöthen MM, Ludwig M, Reutter H, Hildebrandt F. Hilger AC, et al. Hum Mutat. 2015 Dec;36(12):1150-4. doi: 10.1002/humu.22859. Epub 2015 Sep 14. Hum Mutat. 2015. PMID: 26294094 Free PMC article.
We detected no biallelic mutation in any of the 25 ciliary candidate genes; however, identified an identical, probably disease-causing ZIC3 missense mutation (p.Gly17Cys) in four patients and a FOXF1 de novo mutation (p.Gly220Cys) in a further patient. ...These data provid …
We detected no biallelic mutation in any of the 25 ciliary candidate genes; however, identified an identical, probably disease-causing ZI …
29 results