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Integrative genomic profiling reveals characteristics of lymph node metastasis in small cell lung cancer.
Kong K, Hu S, Yue J, Yang Z, Jabbour SK, Deng Y, Zhao B, Li F. Kong K, et al. Transl Lung Cancer Res. 2023 Feb 28;12(2):295-311. doi: 10.21037/tlcr-22-785. Epub 2023 Feb 13. Transl Lung Cancer Res. 2023. PMID: 36895932 Free PMC article.
BACKGROUND: Small cell lung cancer (SCLC) is the most aggressive lung cancer subtype, with more than 70% of patients having metastatic disease and a poor prognosis. ...RESULTS: The results of WES revealed that the most common mutations occurred in TTN (85%) and TP53 …
BACKGROUND: Small cell lung cancer (SCLC) is the most aggressive lung cancer subtype, with more than 70% of patients having me …
A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database.
Pappula AL, Rasheed S, Mirzaei G, Petreaca RC, Bouley RA. Pappula AL, et al. Cancers (Basel). 2021 Aug 26;13(17):4299. doi: 10.3390/cancers13174299. Cancers (Basel). 2021. PMID: 34503108 Free PMC article.
Here, we investigated the genetic background of IDH1-mutant gliomas using the Catalogue of Somatic Mutations in Cancer (COSMIC) database. In astrocytoma patients, we found that IDH1 is often co-mutated with TP53, ATRX, AMBRA1, PREX1, and NOTCH1, but not CHEK2, EGFR, PTEN, …
Here, we investigated the genetic background of IDH1-mutant gliomas using the Catalogue of Somatic Mutations in Cancer (COSMIC) datab …
Characteristics of genomic mutations and signaling pathway alterations in thymic epithelial tumors.
Yang W, Chen S, Cheng X, Xu B, Zeng H, Zou J, Su C, Chen Z. Yang W, et al. Ann Transl Med. 2021 Nov;9(22):1659. doi: 10.21037/atm-21-5182. Ann Transl Med. 2021. PMID: 34988168 Free PMC article.
BACKGROUND: To elucidate the mechanisms of thymic epithelial tumor (TET) canceration by characterizing genomic mutations and signaling pathway alterations. ...The ErbB signaling pathway was enriched in the thymoma and intersection groups, and pathways of central carbon met …
BACKGROUND: To elucidate the mechanisms of thymic epithelial tumor (TET) canceration by characterizing genomic mutations and signalin …