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ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
Yelagandula R, Stecher K, Novatchkova M, Michetti L, Michlits G, Wang J, Hofbauer P, Vainorius G, Pribitzer C, Isbel L, Mendjan S, Schübeler D, Elling U, Brennecke J, Bell O. Yelagandula R, et al. Nat Cell Biol. 2023 Jan;25(1):42-55. doi: 10.1038/s41556-022-01051-2. Epub 2023 Jan 5. Nat Cell Biol. 2023. PMID: 36604593 Free PMC article.
ZNF462 haploinsufficiency is linked to Weiss-Kruszka syndrome, a genetic disorder characterized by neurodevelopmental defects, including autism. ...Our results suggest that aberrant activation of lineage non-specific genes in the neuronal lineage underlies ZNF462-as
ZNF462 haploinsufficiency is linked to Weiss-Kruszka syndrome, a genetic disorder characterized by neurodevelopmental defects, includ
Robust prognostic model based on immune infiltration-related genes and clinical information in ovarian cancer.
Zhang X, Kong W, Gao M, Huang W, Peng C, Huang Z, Xie Z, Guo H. Zhang X, et al. J Cell Mol Med. 2022 Jul;26(13):3659-3674. doi: 10.1111/jcmm.17360. Epub 2022 Jun 23. J Cell Mol Med. 2022. PMID: 35735060 Free PMC article.

Immune infiltration of ovarian cancer (OV) is a critical factor in determining patient's prognosis. ...Chi-squared tests revealed that 6 mutations are significantly (p < 0.05) related to immune infiltration: BRCA1, ZNF462, VWF, RBAK, RB1 and ADGRV1. According to

Immune infiltration of ovarian cancer (OV) is a critical factor in determining patient's prognosis. ...Chi-squared tests revealed tha …
Induction, modulation and potential targets of miR-210 in pancreatic cancer cells.
Chen WY, Liu WJ, Zhao YP, Zhou L, Zhang TP, Chen G, Shu H. Chen WY, et al. Hepatobiliary Pancreat Dis Int. 2012 Jun;11(3):319-24. doi: 10.1016/s1499-3872(12)60168-4. Hepatobiliary Pancreat Dis Int. 2012. PMID: 22672828
BACKGROUND: MiR-210 is induced by hypoxia and plays different roles in the development of certain cancers. However, little is known about its role in pancreatic cancer (PC). ...CONCLUSIONS: These results suggest that miR-210 expression in PC cells is induced by hypo …
BACKGROUND: MiR-210 is induced by hypoxia and plays different roles in the development of certain cancers. However, little is known a …
Acute lymphoblastic leukemia in a child with Weiss-Kruszka syndrome: Casual or causal association?
Pellino G, Chiasso L, Fiori G, Mazzone S, Zama D, Cordelli DM, Russo A. Pellino G, et al. Eur J Med Genet. 2022 Apr;65(4):104457. doi: 10.1016/j.ejmg.2022.104457. Epub 2022 Feb 16. Eur J Med Genet. 2022. PMID: 35182807
Weiss-Kruszka syndrome is a recently described genetic disorder characterized by craniofacial features, ptosis, dysgenesis of the corpus callosum, and neurodevelopmental impairment. It is caused by heterozygous loss-of-function variantsin ZNF462 gene. During the time, the …
Weiss-Kruszka syndrome is a recently described genetic disorder characterized by craniofacial features, ptosis, dysgenesis of the corpus cal …
The presence of clear cell glands around the ovarian endometrioid cyst has an association with clear cell carcinoma.
Qu J, Yu J, Zhong S, Wang W, Wang Q, Du B. Qu J, et al. Virchows Arch. 2023 Jun;482(6):1021-1034. doi: 10.1007/s00428-022-03479-1. Epub 2022 Dec 29. Virchows Arch. 2023. PMID: 36580137
Some cases of EC-CCG had IHC results similar to those of CCBT and CCC, with positive expression of HNF1beta and NapsinA; decreased expression of ER, PR, and ARID1A; and increased expression of Ki67 (> 5%). WES results revealed that EC-CCG had mutations in TP53BP1, ZNF462
Some cases of EC-CCG had IHC results similar to those of CCBT and CCC, with positive expression of HNF1beta and NapsinA; decreased expressio …