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2007 2
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ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer.
Li L, Liu ZH, Wang HJ, Wang L, Ru GQ, Wang YY. Li L, et al. Gastroenterol Res Pract. 2022 Oct 19;2022:5288075. doi: 10.1155/2022/5288075. eCollection 2022. Gastroenterol Res Pract. 2022. PMID: 36311294 Free PMC article.
AIM: To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gastric cancer. METHODS: Expression of ZNF521 was examined by immunohistochemistry in gastric cancer cases. ...RESULTS: Th …
AIM: To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gas …
Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers.
Chiarella E, Aloisio A, Scicchitano S, Bond HM, Mesuraca M. Chiarella E, et al. Int J Mol Sci. 2021 Aug 6;22(16):8461. doi: 10.3390/ijms22168461. Int J Mol Sci. 2021. PMID: 34445164 Free PMC article. Review.
ZNF521 is a stem cell-associated co-transcription factor implicated in the regulation of hematopoietic, neural, and mesenchymal stem cells. The aberrant expression of ZNF521 transcripts, frequently associated with miRNA deregulation, has been detected in several tum …
ZNF521 is a stem cell-associated co-transcription factor implicated in the regulation of hematopoietic, neural, and mesenchymal stem …
ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia.
Germano G, Morello G, Aveic S, Pinazza M, Minuzzo S, Frasson C, Persano L, Bonvini P, Viola G, Bresolin S, Tregnago C, Paganin M, Pigazzi M, Indraccolo S, Basso G. Germano G, et al. Oncotarget. 2017 Apr 18;8(16):26129-26141. doi: 10.18632/oncotarget.15387. Oncotarget. 2017. PMID: 28412727 Free PMC article.
Recently, independent gene expression profile studies have evidenced a positive correlation between ZNF521 mRNA overexpression and MLL-rearranged acute myeloid leukemia (AML), leaving open the question on the role of ZNF521 in this subtype of leukemia. ...Finally, w …
Recently, independent gene expression profile studies have evidenced a positive correlation between ZNF521 mRNA overexpression and ML …
ZNF521/EBF1 axis regulates AKR1B1 to promote the proliferation, migration, and invasion of gastric cancer cells.
Cheng Y, Ni YJ, Tang LM. Cheng Y, et al. Kaohsiung J Med Sci. 2023 Mar;39(3):244-253. doi: 10.1002/kjm2.12624. Epub 2022 Nov 17. Kaohsiung J Med Sci. 2023. PMID: 36397644 Free article.
Although the incidence and death rates of gastric cancer (GC) are decreasing, approximately one million new cases and 800,000 GC-related deaths were reported worldwide in 2018. ...Notably, knockdown of ZNF521 attenuated GC progression and was rescued by overexpressi …
Although the incidence and death rates of gastric cancer (GC) are decreasing, approximately one million new cases and 800,000 GC-rela …
ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer.
Bond HM, Scicchitano S, Chiarella E, Amodio N, Lucchino V, Aloisio A, Montalcini Y, Mesuraca M, Morrone G. Bond HM, et al. Front Endocrinol (Lausanne). 2018 May 18;9:255. doi: 10.3389/fendo.2018.00255. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 29867779 Free PMC article. Review.
Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estrogen receptor modulators (SERMs) and reduce the incidence of BC. ...ZNF423, which was not previously associated with BC is a multifunctional transcription factor known to ha …
Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estrogen receptor modulators (SERMs) …
Enhanced ZNF521 expression induces an aggressive phenotype in human ovarian carcinoma cell lines.
Scicchitano S, Montalcini Y, Lucchino V, Melocchi V, Gigantino V, Chiarella E, Bianchi F, Weisz A, Mesuraca M. Scicchitano S, et al. PLoS One. 2022 Oct 3;17(10):e0274785. doi: 10.1371/journal.pone.0274785. eCollection 2022. PLoS One. 2022. PMID: 36191006 Free PMC article.
Increased ZNF521 expression resulted in an enhancement of OC HeyA8 and ES-2 cell growth and motility. Analysis of RNA isolated from transduced cells by RNA-Seq and qRT-PCR revealed that several genes involved in growth, proliferation, migration and tumor invasiveness are d …
Increased ZNF521 expression resulted in an enhancement of OC HeyA8 and ES-2 cell growth and motility. Analysis of RNA isolated from t …
ZNF521 Has an Inhibitory Effect on the Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.
Chiarella E, Aloisio A, Codispoti B, Nappo G, Scicchitano S, Lucchino V, Montalcini Y, Camarotti A, Galasso O, Greco M, Gasparini G, Mesuraca M, Bond HM, Morrone G. Chiarella E, et al. Stem Cell Rev Rep. 2018 Dec;14(6):901-914. doi: 10.1007/s12015-018-9830-0. Stem Cell Rev Rep. 2018. PMID: 29938352
Conversely, silencing of ZNF521 was found to significantly enhance the adipogenic differentiation of hADSCs. Inhibition of adipogenesis by ZNF521 was at least in part due to inhibition of EBF1. Taken together, these results confirm a role for ZNF521 as a key …
Conversely, silencing of ZNF521 was found to significantly enhance the adipogenic differentiation of hADSCs. Inhibition of adipogenes …
ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.
Mesuraca M, Chiarella E, Scicchitano S, Codispoti B, Giordano M, Nappo G, Bond HM, Morrone G. Mesuraca M, et al. Biomed Res Int. 2015;2015:165238. doi: 10.1155/2015/165238. Epub 2015 Dec 16. Biomed Res Int. 2015. PMID: 26788497 Free PMC article. Review.
In particular, two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias. ...
In particular, two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of …
ZNF521 which is downregulated by miR-802 suppresses malignant progression of Hepatocellular Carcinoma through regulating Runx2 expression.
Yang N, Wang L, Chen T, Liu R, Liu Z, Zhang L. Yang N, et al. J Cancer. 2020 Aug 1;11(19):5831-5839. doi: 10.7150/jca.45190. eCollection 2020. J Cancer. 2020. PMID: 32913476 Free PMC article.
Zinc finger protein 521 (ZNF521) plays an important role in the tumor development and process. ...Moreover, we demonstrated that ZNF521 expression was regulated by miR-802. In HCC tissues. MiR-802 has an inverse correlation with ZNF521 expression. ...
Zinc finger protein 521 (ZNF521) plays an important role in the tumor development and process. ...Moreover, we demonstrated that Z …
ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape.
Chiarella E, Aloisio A, Scicchitano S, Todoerti K, Cosentino EG, Lico D, Neri A, Amodio N, Bond HM, Mesuraca M. Chiarella E, et al. Int J Mol Sci. 2021 Oct 6;22(19):10814. doi: 10.3390/ijms221910814. Int J Mol Sci. 2021. PMID: 34639154 Free PMC article.
Transcriptome analysis of primary CD34(+) cultures displayed subsets of genes up-regulated by MLL-AF9 or ZNF521 single transgene overexpression as well as in MLL-AF9/ZNF521 combinations, at either the early or late time points of an in vitro leukemogenesis model. Th …
Transcriptome analysis of primary CD34(+) cultures displayed subsets of genes up-regulated by MLL-AF9 or ZNF521 single transgene over …
37 results