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ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression.
Wu G, Peng H, Tang M, Yang M, Wang J, Hu Y, Li Z, Li J, Li Z, Song L. Wu G, et al. EBioMedicine. 2021 Sep;71:103558. doi: 10.1016/j.ebiom.2021.103558. Epub 2021 Sep 11. EBioMedicine. 2021. PMID: 34521054 Free PMC article.
BACKGROUND: Resistance to platinum-based chemotherapy is a major cause of therapeutic failure during the treatment of epithelial ovarian cancer (EOC) patients. Our study aims to elucidate the molecular mechanisms by which ZNF711 down regulation promotes CISPLATIN re …
BACKGROUND: Resistance to platinum-based chemotherapy is a major cause of therapeutic failure during the treatment of epithelial ovarian …
Clinical Significance of ZNF711 in Human Breast Cancer.
Li X, Tian L, Zhang L, Xu B, Zhang Y, Li Q. Li X, et al. Onco Targets Ther. 2020 Jul 6;13:6593-6601. doi: 10.2147/OTT.S251702. eCollection 2020. Onco Targets Ther. 2020. PMID: 32753895 Free PMC article.
PURPOSE: To investigate the clinicopathologic and prognostic significance of the zinc-finger protein 711 (ZNF711) in breast cancer (BCa). MATERIALS AND METHODS: The relevance of ZNF711 in BCa was analyzed using bioinformatics. ...Survival analysis results sho …
PURPOSE: To investigate the clinicopathologic and prognostic significance of the zinc-finger protein 711 (ZNF711) in breast cancer …
Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.
Ni W, Perez AA, Schreiner S, Nicolet CM, Farnham PJ. Ni W, et al. Nucleic Acids Res. 2020 Jun 19;48(11):5986-6000. doi: 10.1093/nar/gkaa384. Nucleic Acids Res. 2020. PMID: 32406922 Free PMC article.
Our study focuses on a family of ubiquitously expressed human C2H2 zinc finger proteins comprised of ZFX, ZFY and ZNF711. Although their protein structure suggests that ZFX, ZFY and ZNF711 are transcriptional regulators, the mechanisms by which they influence transc …
Our study focuses on a family of ubiquitously expressed human C2H2 zinc finger proteins comprised of ZFX, ZFY and ZNF711. Although th …
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR. Tarpey PS, et al. Nat Genet. 2009 May;41(5):535-43. doi: 10.1038/ng.367. Epub 2009 Apr 19. Nat Genet. 2009. PMID: 19377476 Free PMC article.
The screen has discovered nine genes implicated in XLMR, including SYP, ZNF711 and CASK reported here, confirming the power of this strategy. ...
The screen has discovered nine genes implicated in XLMR, including SYP, ZNF711 and CASK reported here, confirming the power of this s …
Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure.
Rua AJ, Alexandrescu AT. Rua AJ, et al. bioRxiv [Preprint]. 2024 Apr 10:2024.04.06.588434. doi: 10.1101/2024.04.06.588434. bioRxiv. 2024. PMID: 38645208 Free PMC article. Preprint.
Domain Z7 of nuclear transcription factor ZNF711 has the consensus last metal-ligand H23 found in odd-numbered zinc-fingers of this protein replaced by a phenylalanine. Ever since the discovery of ZNF711 it has been thought that Z7 is probably non-functional because …
Domain Z7 of nuclear transcription factor ZNF711 has the consensus last metal-ligand H23 found in odd-numbered zinc-fingers of this p …
ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters.
Rhie SK, Yao L, Luo Z, Witt H, Schreiner S, Guo Y, Perez AA, Farnham PJ. Rhie SK, et al. Genome Res. 2018 Feb 2;28(3):310-20. doi: 10.1101/gr.228809.117. Online ahead of print. Genome Res. 2018. PMID: 29429977 Free PMC article.
We performed ChIP-seq in four cancer cell lines (representing kidney, colon, prostate, and breast cancers) to identify ZFX binding sites throughout the human genome. ...We have also shown that a closely related zinc finger protein ZNF711 has a similar binding …
We performed ChIP-seq in four cancer cell lines (representing kidney, colon, prostate, and breast cancers) to identify ZFX bin …
Prediction of competing endogenous RNA coexpression network as prognostic markers in AML.
Wang JD, Zhou HS, Tu XX, He Y, Liu QF, Liu Q, Long ZJ. Wang JD, et al. Aging (Albany NY). 2019 May 31;11(10):3333-3347. doi: 10.18632/aging.101985. Aging (Albany NY). 2019. PMID: 31164492 Free PMC article.
Recently, competing endogenous RNAs (ceRNAs) hypothesis has gained a great interest in the study of molecular biological mechanisms of cancer occurrence and progression. However, studies on leukemia are limited, and there is still a lack of comprehensive analysis of lncRNA …
Recently, competing endogenous RNAs (ceRNAs) hypothesis has gained a great interest in the study of molecular biological mechanisms of ca …
Dysregulation of X chromosome inactivation in high grade ovarian serous adenocarcinoma.
Kang J, Lee HJ, Kim J, Lee JJ, Maeng LS. Kang J, et al. PLoS One. 2015 Mar 5;10(3):e0118927. doi: 10.1371/journal.pone.0118927. eCollection 2015. PLoS One. 2015. PMID: 25742136 Free PMC article.
Loss of X chromosome inactivation (XCI) is observed in breast and ovarian cancers, and is frequent in basal-like subtype and BRCA1 mutation-associated breast cancers. We investigated the clinical implications of the loss of XCI in ovarian cancer and the assoc …
Loss of X chromosome inactivation (XCI) is observed in breast and ovarian cancers, and is frequent in basal-like subtype and BRCA1 mu …