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ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes.
Cassandri M, Butera A, Amelio I, Lena AM, Montanaro M, Mauriello A, Anemona L, Candi E, Knight RA, Agostini M, Melino G. Cassandri M, et al. Oncogene. 2020 May;39(22):4331-4343. doi: 10.1038/s41388-020-1277-5. Epub 2020 Apr 20. Oncogene. 2020. PMID: 32313225
Gene expression analysis in cancer patient datasets indicated that ZNF750 and its targets were negative prognostic factors in breast cancer. Together, our findings shed light on the molecular mechanism by which ZNF750 regulates cell migration and invas …
Gene expression analysis in cancer patient datasets indicated that ZNF750 and its targets were negative prognostic factors in …
The ZNF750-RAC1 axis as potential prognostic factor for breast cancer.
Butera A, Cassandri M, Rugolo F, Agostini M, Melino G. Butera A, et al. Cell Death Discov. 2020 Nov 29;6(1):135. doi: 10.1038/s41420-020-00371-2. Cell Death Discov. 2020. PMID: 33298895 Free PMC article.
In keeping with ZNF750 controlling RAC1 expression, we found an inverse correlation between ZNF750 and RAC1 in human breast cancer datasets. ...Overall, our findings provide a novel molecular mechanism by which ZNF750 acts as tumour suppressor gene. He …
In keeping with ZNF750 controlling RAC1 expression, we found an inverse correlation between ZNF750 and RAC1 in human breast …
ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer.
Montanaro M, Agostini M, Anemona L, Bonanno E, Servadei F, Finazzi Agrò E, Asimakopoulos AD, Ganini C, Cipriani C, Signoretti M, Bove P, Rugolo F, Imperiali B, Melino G, Mauriello A, Scimeca M. Montanaro M, et al. Int J Mol Sci. 2023 Mar 30;24(7):6519. doi: 10.3390/ijms24076519. Int J Mol Sci. 2023. PMID: 37047491 Free PMC article.
Prostate cancer is the most frequently diagnosed cancer and the fifth leading cause of cancer death among men in 2020. ...The data reported here revealed that ZNF750 protein levels are reduced in human prostate cancer samples, and this reduction …
Prostate cancer is the most frequently diagnosed cancer and the fifth leading cause of cancer death among men in 2020. …
TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.
Yi Q, Zhao Y, Xia R, Wei Q, Chao F, Zhang R, Bian P, Lv L. Yi Q, et al. Cell Death Discov. 2023 Jun 26;9(1):191. doi: 10.1038/s41420-023-01491-1. Cell Death Discov. 2023. PMID: 37365152 Free PMC article.
Herein, we identify skin-related signatures as the most deficient signatures in invasive ESCA, which are regulated by the transcription factor ZNF750. Of note, we find that TRIM29 level strongly correlated with the expression of many genes in the skin-related signatures, i …
Herein, we identify skin-related signatures as the most deficient signatures in invasive ESCA, which are regulated by the transcription fact …
DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy.
Manoochehri M, Borhani N, Gerhäuser C, Assenov Y, Schönung M, Hielscher T, Christensen BC, Lee MK, Gröne HJ, Lipka DB, Brüning T, Brauch H, Ko YD, Hamann U. Manoochehri M, et al. Int J Cancer. 2023 Mar 1;152(5):1025-1035. doi: 10.1002/ijc.34337. Epub 2022 Nov 8. Int J Cancer. 2023. PMID: 36305646 Free article. Review.
Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for earlier detection of triple-negative breast cancer (TNBC) which could help clinicians with easier and more efficient treatment options. ...A methylation score combining signatures of …
Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for earlier detection of triple-negative breast can …
Zinc finger protein 750(ZNF750), negatively regulated by miR-17-5p, inhibits proliferation, motility and invasion of colonic cancer cells.
Qu J, Zhang X, Lv X. Qu J, et al. J Gene Med. 2020 Aug;22(8):e3195. doi: 10.1002/jgm.3195. Epub 2020 May 7. J Gene Med. 2020. PMID: 32246873
The expression of ZNF750 in colonic cancer cells was detected using western blotting. ...RESULTS: The expression level of ZNF750 in colonic cancer tissues, as well as colonic cancer cell lines, was significantly down-regulated. ...
The expression of ZNF750 in colonic cancer cells was detected using western blotting. ...RESULTS: The expression level of Z …
ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.
Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP. Hazawa M, et al. Oncogene. 2017 Apr 20;36(16):2243-2254. doi: 10.1038/onc.2016.377. Epub 2016 Nov 7. Oncogene. 2017. PMID: 27819679 Free PMC article.
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). ...Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which …
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations …
m(6)A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, Ma J, Liu N. Zhang P, et al. Cell Death Dis. 2018 Dec 5;9(12):1169. doi: 10.1038/s41419-018-1224-3. Cell Death Dis. 2018. PMID: 30518868 Free PMC article.
Ectopic expression of ZNF750 blocked NPC growth in vitro and in vivo. Further studies revealed that m(6)A modifications maintained the low expression level of ZNF750 in NPC. Chromatin immunoprecipitation sequencing identified that ZNF750 directly regulated FG …
Ectopic expression of ZNF750 blocked NPC growth in vitro and in vivo. Further studies revealed that m(6)A modifications maintained th …
ZNF750 inhibits the proliferation and invasion of melanoma cells through modulating the Wnt/b-catenin signaling pathway.
Du Y, Lv G, Jing C, Liu J, Liu J. Du Y, et al. Folia Histochem Cytobiol. 2020;58(4):255-263. doi: 10.5603/FHC.a2020.0026. Epub 2020 Nov 13. Folia Histochem Cytobiol. 2020. PMID: 33185885 Free article.
INTRODUCTION: The abnormal expression of Zinc Finger Protein 750 (ZNF750) has been reported in neoplastic diseases. This study investigated the functional role of ZNF750 in the progression of melanoma. ...In addition, overexpression of ZNF750 decreased the pr …
INTRODUCTION: The abnormal expression of Zinc Finger Protein 750 (ZNF750) has been reported in neoplastic diseases. This study invest …
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma.
North JP, Solomon DA, Golovato J, Bloomer M, Benz SC, Cho RJ. North JP, et al. J Cutan Pathol. 2019 Oct;46(10):736-741. doi: 10.1111/cup.13516. Epub 2019 Jul 8. J Cutan Pathol. 2019. PMID: 31148199 Free PMC article. Clinical Trial.
In nine previously sequenced ocular SeCs, two lacked detectable somatic mutations in ZNF750, but showed complete loss of staining, indicating non-mutational inactivation of ZNF750. CONCLUSION: We show complete loss of the ZNF750 epidermal differentiation regu …
In nine previously sequenced ocular SeCs, two lacked detectable somatic mutations in ZNF750, but showed complete loss of staining, in …
61 results