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Year Number of Results
2010 1
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2014 7
2015 13
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2018 14
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2020 18
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2023 7
2024 3

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110 results

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Page 1
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Belenguer G, Mastrogiovanni G, Pacini C, Hall Z, Dowbaj AM, Arnes-Benito R, Sljukic A, Prior N, Kakava S, Bradshaw CR, Davies S, Vacca M, Saeb-Parsy K, Koo BK, Huch M. Belenguer G, et al. Nat Commun. 2022 Jan 17;13(1):334. doi: 10.1038/s41467-021-27923-z. Nat Commun. 2022. PMID: 35039505 Free PMC article.
RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown. ...Our results imply that RNF43/ZNRF3 predispose to liver cancer by controlling the proliferati …
RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contributio …
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/beta-catenin signaling activation (Review).
Katoh M. Katoh M. Int J Mol Med. 2018 Aug;42(2):713-725. doi: 10.3892/ijmm.2018.3689. Epub 2018 May 17. Int J Mol Med. 2018. PMID: 29786110 Free PMC article. Review.
beta-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and alpha-catenins), transmembrane-type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP5 …
beta-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE-cadher …
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer.
Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y. Yue F, et al. bioRxiv [Preprint]. 2024 Jan 11:2024.01.10.574969. doi: 10.1101/2024.01.10.574969. bioRxiv. 2024. PMID: 38260423 Free PMC article. Preprint.
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. ...Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of ZNRF3 …
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. ...Ov …
Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer.
Hao HX, Jiang X, Cong F. Hao HX, et al. Cancers (Basel). 2016 Jun 8;8(6):54. doi: 10.3390/cancers8060054. Cancers (Basel). 2016. PMID: 27338477 Free PMC article. Review.
R-spondin proteins (RSPO1-4) serve as natural antagonists of ZNRF3/RNF43. To maintain strong and sustained Wnt/beta-catenin signaling, cancers need to overcome ZNRF3/RNF43-mediated feedback inhibition. Indeed, mutations of RNF43/ZNRF3 and recurrent tra …
R-spondin proteins (RSPO1-4) serve as natural antagonists of ZNRF3/RNF43. To maintain strong and sustained Wnt/beta-catenin signaling …
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
de Lau W, Peng WC, Gros P, Clevers H. de Lau W, et al. Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113. Genes Dev. 2014. PMID: 24532711 Free PMC article. Review.
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. ...Rnf43/Znrf3 are themselves encoded by Wnt target genes and …
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identifie …
ZnRF3 Induces Apoptosis of Gastric Cancer Cells by Antagonizing Wnt and Hedgehog Signaling.
Qin H, Cai A, Xi H, Yuan J, Chen L. Qin H, et al. Cell Biochem Biophys. 2015 Nov;73(2):361-367. doi: 10.1007/s12013-015-0607-7. Cell Biochem Biophys. 2015. PMID: 27352324
Deregulated cell proliferative signaling via Wnt/beta-catenin and Hedgehog pathways is considered important in the pathogenesis of many cancers including the gastric cancer. Recent studies identified ZnRF3 protein, which is a E3-ubiquitin ligase and which is …
Deregulated cell proliferative signaling via Wnt/beta-catenin and Hedgehog pathways is considered important in the pathogenesis of many c …
ZnRF3 induces apoptosis of gastric cancer cells by antagonizing Wnt and Hedgehog signaling.
Qin H, Cai A, Xi H, Yuan J, Chen L. Qin H, et al. Panminerva Med. 2015 Dec;57(4):167-75. Epub 2015 Apr 29. Panminerva Med. 2015. PMID: 25923840
Deregulated cell proliferative signaling via Wnt/beta-catenin and Hedgehog pathways is considered important in the pathogenesis of many cancers including the gastric cancer. Recent studies identified ZnRF3 protein, which is a E3-ubiquitin ligase and which is …
Deregulated cell proliferative signaling via Wnt/beta-catenin and Hedgehog pathways is considered important in the pathogenesis of many c …
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the Membrane.
Farnhammer F, Colozza G, Kim J. Farnhammer F, et al. Int J Stem Cells. 2023 Nov 30;16(4):376-384. doi: 10.15283/ijsc23070. Epub 2023 Aug 30. Int J Stem Cells. 2023. PMID: 37643759 Free PMC article. Review.
The E3 ubiquitin ligases RNF43 and ZNRF3, which are known negative regulators of the Wnt pathway, are critical component of Wnt signaling regulation. ...We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3. This review article sum …
The E3 ubiquitin ligases RNF43 and ZNRF3, which are known negative regulators of the Wnt pathway, are critical component of Wnt signa …
Antibody targeting of E3 ubiquitin ligases for receptor degradation.
Marei H, Tsai WK, Kee YS, Ruiz K, He J, Cox C, Sun T, Penikalapati S, Dwivedi P, Choi M, Kan D, Saenz-Lopez P, Dorighi K, Zhang P, Kschonsak YT, Kljavin N, Amin D, Kim I, Mancini AG, Nguyen T, Wang C, Janezic E, Doan A, Mai E, Xi H, Gu C, Heinlein M, Biehs B, Wu J, Lehoux I, Harris S, Comps-Agrar L, Seshasayee D, de Sauvage FJ, Grimmer M, Li J, Agard NJ, de Sousa E Melo F. Marei H, et al. Nature. 2022 Oct;610(7930):182-189. doi: 10.1038/s41586-022-05235-6. Epub 2022 Sep 21. Nature. 2022. PMID: 36131013 Free PMC article.
Here we describe the development of proteolysis-targeting antibodies (PROTABs) that tether cell-surface E3 ubiquitin ligases to transmembrane proteins, resulting in target degradation both in vitro and in vivo. Focusing on zinc- and ring finger 3 (ZNRF3), a Wnt-responsive …
Here we describe the development of proteolysis-targeting antibodies (PROTABs) that tether cell-surface E3 ubiquitin ligases to transmembran …
ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation.
Sun R, Meng Z, Lee H, Offringa R, Niehrs C. Sun R, et al. Cell Chem Biol. 2023 Jul 20;30(7):739-752.e8. doi: 10.1016/j.chembiol.2023.05.010. Epub 2023 Jun 14. Cell Chem Biol. 2023. PMID: 37321224
Here we introduce ROTACs, bispecific WNT- and BMP-signaling-disabled R-spondin (RSPO) chimeras, which leverage the specificity of these stem cell growth factors for ZNRF3/RNF43 E3 transmembrane ligases, to target degradation of transmembrane proteins. As a proof-of-concept …
Here we introduce ROTACs, bispecific WNT- and BMP-signaling-disabled R-spondin (RSPO) chimeras, which leverage the specificity of these stem …
110 results