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Hypoxia-Induced ZWINT Mediates Pancreatic Cancer Proliferation by Interacting With p53/p21.
Chen P, He Z, Wang J, Xu J, Jiang X, Chen Y, Liu X, Jiang J. Chen P, et al. Front Cell Dev Biol. 2021 Nov 24;9:682131. doi: 10.3389/fcell.2021.682131. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34900978 Free PMC article.
p53/p21 signaling plays a vital role in pancreatic cancer (PC) progression. ZWINT was shown to function as an oncoprotein in the progression of multiple cancers. ...ZWINT promoted pancreatic cancer growth and cell cycle progression. ...
p53/p21 signaling plays a vital role in pancreatic cancer (PC) progression. ZWINT was shown to function as an oncoprotein in t …
ZWINT is the next potential target for lung cancer therapy.
Peng F, Li Q, Niu SQ, Shen GP, Luo Y, Chen M, Bao Y. Peng F, et al. J Cancer Res Clin Oncol. 2019 Mar;145(3):661-673. doi: 10.1007/s00432-018-2823-1. Epub 2019 Jan 14. J Cancer Res Clin Oncol. 2019. PMID: 30643969
Knockdown of ZWINT reduced proliferation in NCI H226 and A549 cells (P < 0.05). ...CONCLUSIONS: ZWINT may be a novel target for lung cancer therapy....

Knockdown of ZWINT reduced proliferation in NCI H226 and A549 cells (P < 0.05). ...CONCLUSIONS: ZWINT may be a novel target

…
Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis.
Zeng X, Shi G, He Q, Zhu P. Zeng X, et al. Sci Rep. 2021 Oct 21;11(1):20799. doi: 10.1038/s41598-021-00268-9. Sci Rep. 2021. PMID: 34675265 Free PMC article.
Breast cancer is the most common cancer and the leading cause of cancer-related deaths in women. ...The enriched functions and pathways included cell cycle, oocyte meiosis and the p53 signaling pathway. The DEGs in breast cancer have the potential to b …
Breast cancer is the most common cancer and the leading cause of cancer-related deaths in women. ...The enriched functi …
ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
Ma Z, Cai Y, Tian C. Ma Z, et al. Chin J Physiol. 2023 Sep-Oct;66(5):372-378. doi: 10.4103/cjop.CJOP-D-23-00001. Chin J Physiol. 2023. PMID: 37929349 Free article.
First, ZWINT expression in cervical cancer was analyzed using the bioinformatic methods and assessed in several cervical cancer cell lines. ...Furthermore, ZWINT attenuated the expression of p53 and p21 in cervical cancer cells. ...
First, ZWINT expression in cervical cancer was analyzed using the bioinformatic methods and assessed in several cervical ca …
The overexpression of ZWINT in integrated bioinformatics analysis forecasts poor prognosis in breast cancer.
Shao MT, Hu YZ, Ding H, Wu Q, Pan JH, Zhao XX, Pan YL. Shao MT, et al. Transl Cancer Res. 2020 Jan;9(1):187-193. doi: 10.21037/tcr.2019.12.66. Transl Cancer Res. 2020. PMID: 35117172 Free PMC article.
According to previous studies, it was overexpressed in people with recurrent tumors. However, the expression of ZWINT in breast cancer has not been thoroughly studied. In addition, the correlations of ZWINT to prognosis in breast cancer remain unclear. …
According to previous studies, it was overexpressed in people with recurrent tumors. However, the expression of ZWINT in breast ca …
ZW10 Binding Factor (ZWINT), a Direct Target of Mir-204, Predicts Poor Survival and Promotes Proliferation in Breast Cancer.
Zhou G, Shen M, Zhang Z. Zhou G, et al. Med Sci Monit. 2020 Apr 5;26:e921659. doi: 10.12659/MSM.921659. Med Sci Monit. 2020. PMID: 32248204 Free PMC article.
Then, different bioinformatic analyses were combined to explore the potential cancer-related hallmark underlying ZWINT in breast cancer, and a series of experiments in vitro were performed to reveal the oncogenic role of ZWINT in breast cancer. …
Then, different bioinformatic analyses were combined to explore the potential cancer-related hallmark underlying ZWINT in brea …
KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer.
Akabane S, Oue N, Sekino Y, Asai R, Thang PQ, Taniyama D, Sentani K, Yukawa M, Toda T, Kimura KI, Egi H, Shimizu W, Ohdan H, Yasui W. Akabane S, et al. Pathol Int. 2021 Jul;71(7):441-452. doi: 10.1111/pin.13098. Epub 2021 Apr 5. Pathol Int. 2021. PMID: 33819373
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. ...KIFC1 siRNA-transfected cells showed reduced ZWINT expression while ZWINT siRNA-transfected cells decreased cell proliferation. ...
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. ...KIFC1 siRNA-transfected cells sh …
Involvement of the NF-kappaB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells.
Kim JH, Youn Y, Lee JC, Kim J, Hwang JH. Kim JH, et al. J Cancer. 2020 Jul 25;11(19):5601-5611. doi: 10.7150/jca.46173. eCollection 2020. J Cancer. 2020. PMID: 32913455 Free PMC article.
Pancreatic cancer (PC) is an intractable cancer that is difficult to diagnose early and has a 5-year survival rate of less than 8%. ...However, the mechanism through which Zwint-1 promotes PC progression is yet to be elucidated. Here, we report that Zwint …
Pancreatic cancer (PC) is an intractable cancer that is difficult to diagnose early and has a 5-year survival rate of less tha …
ZWINT is a Promising Therapeutic Biomarker Associated with the Immune Microenvironment of Hepatocellular Carcinoma.
Lin T, Zhang Y, Lin Z, Peng L. Lin T, et al. Int J Gen Med. 2021 Oct 30;14:7487-7501. doi: 10.2147/IJGM.S340057. eCollection 2021. Int J Gen Med. 2021. PMID: 34744456 Free PMC article.
BACKGROUND: The prognosis of patients with advanced hepatocellular carcinoma (HCC) is still poor, effective therapeutic targets are needed. ZW10 interacting kinetochore protein (Zwint) is an essential component of the mitotic spindle checkpoint and is upregulated in can …
BACKGROUND: The prognosis of patients with advanced hepatocellular carcinoma (HCC) is still poor, effective therapeutic targets are needed. …
Bioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer.
Yuan W, Xie S, Wang M, Pan S, Huang X, Xiong M, Xiao RJ, Xiong J, Zhang QP, Shao L. Yuan W, et al. Onco Targets Ther. 2018 Mar 23;11:1683-1695. doi: 10.2147/OTT.S149012. eCollection 2018. Onco Targets Ther. 2018. PMID: 29615843 Free PMC article.
BACKGROUND: ZWINT is a crucial component of the mitotic checkpoint. However, its possible role in lung cancer is unclear. ...Additionally, high expression of ZWINT might predict poor OS and DFS in lung cancer patients. Moreover, disease stage and expre …
BACKGROUND: ZWINT is a crucial component of the mitotic checkpoint. However, its possible role in lung cancer is unclear. ...A …
90 results