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[Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
He JY, Zhou XQ, Wang WT. He JY, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Sep;53(5):744-751. doi: 10.12182/20220960505. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022. PMID: 36224673 Free PMC article. Chinese.
Western blot results showed that ZADH2 protein expression of the miR-3679 inhibitor group was higher than that of the NC group (P<0.01). ...CONCLUSION: miRNA-3679 is significantly highly expressed in HCC cells and miRNA-3679 can directly interact with ZADH2 gene …
Western blot results showed that ZADH2 protein expression of the miR-3679 inhibitor group was higher than that of the NC group (P< …
Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
Goroshchuk O, Kolosenko I, Kunold E, Vidarsdottir L, Pirmoradian M, Azimi A, Jafari R, Palm-Apergi C. Goroshchuk O, et al. FASEB J. 2021 Jul;35(7):e21741. doi: 10.1096/fj.202100457RR. FASEB J. 2021. PMID: 34143546
Comparison of this result with the mass-spectrometry analysis of volasertib-treated cells showed that phosphatidylinositol phosphate and prostaglandin metabolism pathways are affected by volasertib. We confirmed that PIP4K2A and ZADH2-marker proteins for these pathways-are …
Comparison of this result with the mass-spectrometry analysis of volasertib-treated cells showed that phosphatidylinositol phosphate and pro …
DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.
Madrid A, Hogan KJ, Papale LA, Clark LR, Asthana S, Johnson SC, Alisch RS. Madrid A, et al. J Alzheimers Dis. 2018;66(3):927-934. doi: 10.3233/JAD-180592. J Alzheimers Dis. 2018. PMID: 30372681 Free PMC article.
In patients with LOAD, 12 of the shared 17 DMPs were hypomethylated in B3GALT4 (Beta-1,3-galatcosyltransferase 4) (EC 2.4.1.62), and 5 were hypomethylated in ZADH2 (Prostaglandin reductase 3) (EC 1.3.1.48)....
In patients with LOAD, 12 of the shared 17 DMPs were hypomethylated in B3GALT4 (Beta-1,3-galatcosyltransferase 4) (EC 2.4.1.62), and 5 were …
Insights Into the Peroxisomal Protein Inventory of Zebrafish.
Kamoshita M, Kumar R, Anteghini M, Kunze M, Islinger M, Martins Dos Santos V, Schrader M. Kamoshita M, et al. Front Physiol. 2022 Feb 28;13:822509. doi: 10.3389/fphys.2022.822509. eCollection 2022. Front Physiol. 2022. PMID: 35295584 Free PMC article.
Through bioinformatics analysis of all PTS1-carrying proteins, we demonstrate that D. rerio lacks two well-known mammalian peroxisomal proteins (BAAT and ZADH2/PTGR3), but possesses a putative peroxisomal malate synthase (Mlsl) and verified differences in the presence of p …
Through bioinformatics analysis of all PTS1-carrying proteins, we demonstrate that D. rerio lacks two well-known mammalian peroxisomal prote …
Identification of 2.3-Mb gene locus for congenital aural atresia in 18q22.3 deletion: a case report analyzed by comparative genomic hybridization.
Dostal A, Nemeckova J, Gaillyova R, Vranova V, Zezulkova D, Lejska M, Slapak I, Dostalova Z, Kuglik P. Dostal A, et al. Otol Neurotol. 2006 Apr;27(3):427-32. doi: 10.1097/00129492-200604000-00022. Otol Neurotol. 2006. PMID: 16639285 Review.
These polymorphic markers outline a putative critical interval of approximately 2.3 Mb, including the genes ZNF407, ZADH2, SDCCAG33, ZNF516, FLJ44881, ZNF236, MBP-Golli, and GALR1. ...
These polymorphic markers outline a putative critical interval of approximately 2.3 Mb, including the genes ZNF407, ZADH2, SDCCAG33, …
Mapping novel immunogenic epitopes in IgA nephropathy.
Woo SH, Sigdel TK, Dinh VT, Vu MT, Sarwal MM, Lafayette RA. Woo SH, et al. Clin J Am Soc Nephrol. 2015 Mar 6;10(3):372-81. doi: 10.2215/CJN.02390314. Epub 2014 Dec 26. Clin J Am Soc Nephrol. 2015. PMID: 25542908 Free PMC article.
Antitissue transglutaminase IgA was significantly elevated in IgAN (P<0.001, q value of 0%). IgA antibodies to DDX4 (r=-0.55, P=0.01) and ZADH2 (r=-0.48, P=0.02) were significantly correlated with the decline of renal function. ...
Antitissue transglutaminase IgA was significantly elevated in IgAN (P<0.001, q value of 0%). IgA antibodies to DDX4 (r=-0.55, P=0.01) and …
Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity.
Yu YH, Chang YC, Su TH, Nong JY, Li CC, Chuang LM. Yu YH, et al. J Lipid Res. 2013 Sep;54(9):2391-9. doi: 10.1194/jlr.M037556. Epub 2013 Jul 2. J Lipid Res. 2013. PMID: 23821743 Free PMC article.
In this study, we demonstrate that zinc-containing alcohol dehydrogenase 2 (ZADH2; here termed prostaglandin reductase-3, PTGR-3) is a new member of prostaglandin reductase family that converts 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2. ...
In this study, we demonstrate that zinc-containing alcohol dehydrogenase 2 (ZADH2; here termed prostaglandin reductase-3, PTGR-3) is …
Predicted mouse peroxisome-targeted proteins and their actual subcellular locations.
Mizuno Y, Kurochkin IV, Herberth M, Okazaki Y, Schönbach C. Mizuno Y, et al. BMC Bioinformatics. 2008 Dec 12;9 Suppl 12(Suppl 12):S16. doi: 10.1186/1471-2105-9-S12-S16. BMC Bioinformatics. 2008. PMID: 19091015 Free PMC article.
Using CHO-perRed we confirmed the peroxisomal localization of PTS1-targeted candidate Zadh2. Preliminary characterization of Zadh2 expression suggested non-PPARalpha mediated activation. ...
Using CHO-perRed we confirmed the peroxisomal localization of PTS1-targeted candidate Zadh2. Preliminary characterization of Zadh2 …
Mood disorders in individuals with distal 18q deletions.
Daviss WB, O'Donnell L, Soileau BT, Heard P, Carter E, Pliszka SR, Gelfond JA, Hale DE, Cody JD. Daviss WB, et al. Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162B(8):879-88. doi: 10.1002/ajmg.b.32197. Epub 2013 Sep 4. Am J Med Genet B Neuropsychiatr Genet. 2013. PMID: 24006251
A critical region was defined in the mood-disordered group that included a hypothetical gene, C18orf62, and two known genes, ZADH2 and TSHZ1. We conclude that patients having terminal deletions of this critical region of the long arm of Chromosome 18 are highly likely to h …
A critical region was defined in the mood-disordered group that included a hypothetical gene, C18orf62, and two known genes, ZADH2 an …
Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies.
Choi SH, Ruggiero D, Sorice R, Song C, Nutile T, Vernon Smith A, Concas MP, Traglia M, Barbieri C, Ndiaye NC, Stathopoulou MG, Lagou V, Maestrale GB, Sala C, Debette S, Kovacs P, Lind L, Lamont J, Fitzgerald P, Tönjes A, Gudnason V, Toniolo D, Pirastu M, Bellenguez C, Vasan RS, Ingelsson E, Leutenegger AL, Johnson AD, DeStefano AL, Visvikis-Siest S, Seshadri S, Ciullo M. Choi SH, et al. PLoS Genet. 2016 Feb 24;12(2):e1005874. doi: 10.1371/journal.pgen.1005874. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26910538 Free PMC article.
Four were novel loci (5q14.3, 10q21.3, 16q24.2 and 18q22.3) and the leading variants at these loci were rs114694170 (MEF2C, P = 6.79 x 10(-13)), rs74506613 (JMJD1C, P = 1.17 x 10(-19)), rs4782371 (ZFPM1, P = 1.59 x 10(-9)) and rs2639990 (ZADH2, P = 1.72 x 10(-8)), respecti …
Four were novel loci (5q14.3, 10q21.3, 16q24.2 and 18q22.3) and the leading variants at these loci were rs114694170 (MEF2C, P = 6.79 x 10(-1 …
15 results