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ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.
Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CC, Kambe G, Nishikawa S, Menju T, Morinibu A, Okochi Y, Tabuchi Y, Onodera Y, Takeda N, Date H, Semenza GL, Hammond EM, Harada H. Koyasu S, et al. EMBO Rep. 2023 Jan 9;24(1):e54042. doi: 10.15252/embr.202154042. Epub 2022 Nov 7. EMBO Rep. 2023. PMID: 36341521 Free PMC article.
The intratumoral expression levels of ZBTB2 are associated with poor prognosis in lung cancer patients. ZBTB2 N-terminus-mimetic polypeptides competitively inhibit ZBTB2 homodimerization and significantly suppress the ZBTB2-HIF-1 axis, leading to antit …
The intratumoral expression levels of ZBTB2 are associated with poor prognosis in lung cancer patients. ZBTB2 N-terminus-mimet …
ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia.
Chow CCT, Kobayashi M, Kambe G, Harada H. Chow CCT, et al. J Mol Biol. 2023 Aug 1;435(15):168162. doi: 10.1016/j.jmb.2023.168162. Epub 2023 May 29. J Mol Biol. 2023. PMID: 37257772
Here, we demonstrate that zinc finger and BTB domain-containing protein 2 (ZBTB2) enhances the expression of certain HIF-1 target genes under hypoxia. ...In contrast, expression of HIF-1 target genes lacking ZBTB2 peaks, such as carbonic anhydrase 9 (CA9), was not u …
Here, we demonstrate that zinc finger and BTB domain-containing protein 2 (ZBTB2) enhances the expression of certain HIF-1 target gen …
ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.
Bruce JW, Bracken M, Evans E, Sherer N, Ahlquist P. Bruce JW, et al. PLoS Pathog. 2021 Feb 26;17(2):e1009364. doi: 10.1371/journal.ppat.1009364. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33635925 Free PMC article.
Mutations abolishing ZASC1/ZBTB2 interaction prevented ZBTB2 nuclear relocalization. We show that ZBTB2-induced repression depends on interaction of cellular histone deacetylases (HDACs) with the ZBTB2 POZ domain. ...Thus, ZBTB2 is recruited to …
Mutations abolishing ZASC1/ZBTB2 interaction prevented ZBTB2 nuclear relocalization. We show that ZBTB2-induced repress …
ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.
Russo R, Russo V, Cecere F, Valletta M, Gentile MT, Colucci-D'Amato L, Angelini C, Riccio A, Pedone PV, Chambery A, Baglivo I. Russo R, et al. Int J Biol Macromol. 2021 Jan 31;168:67-76. doi: 10.1016/j.ijbiomac.2020.12.029. Epub 2020 Dec 7. Int J Biol Macromol. 2021. PMID: 33301849
In this scenario, ZBTB2 seems to play many functions likely associated with other proteins. Here we report a picture of the ZBTB2 protein partners in U87MG cell line, identified by high-resolution mass spectrometry (MS) that highlights the interplay between ZBTB2 …
In this scenario, ZBTB2 seems to play many functions likely associated with other proteins. Here we report a picture of the ZBTB2 …
ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation.
Karemaker ID, Vermeulen M. Karemaker ID, et al. EMBO Rep. 2018 Apr;19(4):e44993. doi: 10.15252/embr.201744993. Epub 2018 Feb 1. EMBO Rep. 2018. PMID: 29437775 Free PMC article.
The binding of ZBTB2 to its targets is direct and independent of two other zinc finger proteins, ZBTB25 and ZNF639, which we show to interact with ZBTB2. Our data suggest an anticorrelation between ZBTB2 DNA binding and DNA methylation, indicating that ZBT …
The binding of ZBTB2 to its targets is direct and independent of two other zinc finger proteins, ZBTB25 and ZNF639, which we show to …
ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.
Kim MY, Koh DI, Choi WI, Jeon BN, Jeong DY, Kim KS, Kim K, Kim SH, Hur MW. Kim MY, et al. Nucleic Acids Res. 2015 Feb 18;43(3):1609-25. doi: 10.1093/nar/gkv026. Epub 2015 Jan 21. Nucleic Acids Res. 2015. PMID: 25609694 Free PMC article.
Sp1 plays a key role in the expression of the RelA/p65 gene. ZBTB2 represses transcription of the gene by inhibiting Sp1 binding to a Sp1-binding GC-box in the RelA/p65 proximal promoter (bp, -31 to -21). ...Knockdown of ZBTB2 in mouse xenografts decreased tumor gro …
Sp1 plays a key role in the expression of the RelA/p65 gene. ZBTB2 represses transcription of the gene by inhibiting Sp1 binding to a …
ZBTB2, a novel master regulator of the p53 pathway.
Jeon BN, Choi WI, Yu MY, Yoon AR, Kim MH, Yun CO, Hur MW. Jeon BN, et al. J Biol Chem. 2009 Jul 3;284(27):17935-46. doi: 10.1074/jbc.M809559200. Epub 2009 Apr 20. J Biol Chem. 2009. PMID: 19380588 Free PMC article.
ZBTB2 repressed transcription of the ARF, p53, and p21 genes, but activated the HDM2 gene. ...The interactions deacetylated histones Ac-H3 and -H4 at the proximal promoter. Although ectopic ZBTB2 stimulated cell proliferation, knock-down of ZBTB2 expression d …
ZBTB2 repressed transcription of the ARF, p53, and p21 genes, but activated the HDM2 gene. ...The interactions deacetylated histones …
The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency.
Olivieri D, Paramanathan S, Bardet AF, Hess D, Smallwood SA, Elling U, Betschinger J. Olivieri D, et al. J Biol Chem. 2021 Aug;297(2):100947. doi: 10.1016/j.jbc.2021.100947. Epub 2021 Jul 13. J Biol Chem. 2021. PMID: 34270961 Free PMC article.
However, a systematic molecular understanding of the mechanism of action of this TF family is lacking. Here, we identify the zinc finger BTB-TF Zbtb2 from a genetic screen for regulators of exit from pluripotency and demonstrate that its absence perturbs embryonic stem cel …
However, a systematic molecular understanding of the mechanism of action of this TF family is lacking. Here, we identify the zinc finger BTB …
Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts.
Wang D, Wang X, Song Y, Si M, Sun Y, Liu X, Cui S, Qu X, Yu X. Wang D, et al. Cell Death Dis. 2022 Apr 20;13(4):380. doi: 10.1038/s41419-022-04825-6. Cell Death Dis. 2022. PMID: 35443745 Free PMC article.
Importantly, these CRC cell-derived miR-146a-5p and miR-155-5p could be uptaken by CAFs via exosomes and promote the activation of CAFs through JAK2-STAT3/NF-kappaB signaling by targeting suppressor of cytokine signaling 1 (SOCS1) and zinc finger and BTB domain containing 2 (Z …
Importantly, these CRC cell-derived miR-146a-5p and miR-155-5p could be uptaken by CAFs via exosomes and promote the activation of CAFs thro …
AUF1 Promotes Proliferation and Invasion of Thyroid Cancer via Downregulation of ZBTB2 and Subsequent TRIM58.
Du X, Wang JM, Zhang DL, Wu T, Zeng XY, Jiang JY, Du ZX. Du X, et al. Front Oncol. 2021 Jun 16;11:681736. doi: 10.3389/fonc.2021.681736. eCollection 2021. Front Oncol. 2021. PMID: 34222000 Free PMC article.
In addition, two ZBTB2 binding sites (-719~-709 and -677~-668) on TRIM58 promoter and two AUF1 binding sites (1250-1256 and 1258-1265) on ZBTB2 3'-UTR were identified. These results suggested that AUF1 affecting thyroid cancer cells via regulating the expression of …
In addition, two ZBTB2 binding sites (-719~-709 and -677~-668) on TRIM58 promoter and two AUF1 binding sites (1250-1256 and 1258-1265 …
28 results