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Page 1
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S, Shu HB. Lian H, et al. Immunity. 2018 Sep 18;49(3):438-448.e5. doi: 10.1016/j.immuni.2018.08.014. Epub 2018 Sep 4. Immunity. 2018. PMID: 30193849 Free article.
ZCCHC3 deficiency markedly inhibited RNA virus-triggered induction of downstream antiviral genes, and ZCCHC3-deficient mice were more susceptible to RNA virus infection. ...ZCCHC3 bound to dsRNA and enhanced the binding of RIG-I and MDA5 to dsRNA. ...
ZCCHC3 deficiency markedly inhibited RNA virus-triggered induction of downstream antiviral genes, and ZCCHC3-deficient mice we …
ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition.
Goodier JL, Wan H, Soares AO, Sanchez L, Selser JM, Pereira GC, Karma S, García-Pérez JL, Kazazian HH Jr, García Cañadas MM. Goodier JL, et al. PLoS Genet. 2023 Jul 5;19(7):e1010795. doi: 10.1371/journal.pgen.1010795. eCollection 2023 Jul. PLoS Genet. 2023. PMID: 37405998 Free PMC article.
In this study, we investigate Zinc Finger CCHC-Type Containing 3 (ZCCHC3), a gag-like zinc knuckle protein recently reported to function in the innate immune response to infecting viruses. We show that ZCCHC3 also severely restricts human retrotransposons and associ …
In this study, we investigate Zinc Finger CCHC-Type Containing 3 (ZCCHC3), a gag-like zinc knuckle protein recently reported to funct …
ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3.
Zang R, Lian H, Zhong X, Yang Q, Shu HB. Zang R, et al. J Mol Cell Biol. 2020 May 18;12(4):251-262. doi: 10.1093/jmcb/mjaa004. J Mol Cell Biol. 2020. PMID: 32133501 Free PMC article.
Zcchc3-/- mice were more resistant to poly(I:C)- but not lipopolysaccharide-induced inflammatory death. Mechanistically, ZCCHC3 promoted recruitment of TRIF to TLR3 after poly(I:C) stimulation. ...
Zcchc3-/- mice were more resistant to poly(I:C)- but not lipopolysaccharide-induced inflammatory death. Mechanistically, ZCCHC3 …
The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition.
Zhang Z, Zhang N, Guo S, Liu Q, Wang S, Zhang A, Yi D, Zhao J, Li Q, Wang J, Zhang Y, Ma L, Ding J, Cen S, Li X. Zhang Z, et al. Front Microbiol. 2022 Oct 5;13:891852. doi: 10.3389/fmicb.2022.891852. eCollection 2022. Front Microbiol. 2022. PMID: 36274734 Free PMC article.
Further studies show that ZCCHC3 can post-transcriptionally diminish the LINE-1 RNA level. The association of ZCCHC3 with both LINE-1 RNA and ORF1 suggests that ZCCHC3 interacts with LINE-1 RNP and consequently causes its RNA degradation. These data demonstra …
Further studies show that ZCCHC3 can post-transcriptionally diminish the LINE-1 RNA level. The association of ZCCHC3 with both …
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.
Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang XN, Chen YD, Fu YZ, Hu MM, Lei CQ, Luo WW, Li S, Shu HB. Lian H, et al. Nat Commun. 2018 Aug 22;9(1):3349. doi: 10.1038/s41467-018-05559-w. Nat Commun. 2018. PMID: 30135424 Free PMC article.
We show that ZCCHC3-deficiency inhibits dsDNA- and DNA virus-triggered induction of downstream effector genes, and that ZCCHC3-deficient mice are more susceptible to lethal herpes simplex virus type 1 or vaccinia virus infection. ZCCHC3 directly binds to dsDN …
We show that ZCCHC3-deficiency inhibits dsDNA- and DNA virus-triggered induction of downstream effector genes, and that ZCCHC3 …
Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism.
Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH. Yi B, et al. iScience. 2024 Feb 5;27(3):109107. doi: 10.1016/j.isci.2024.109107. eCollection 2024 Mar 15. iScience. 2024. PMID: 38384847 Free PMC article.
Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. ...This distinct, dual-acting antivir …
Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the product …
ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3.
Wang L. Wang L. J Bone Oncol. 2020 Oct 22;26:100335. doi: 10.1016/j.jbo.2020.100335. eCollection 2021 Feb. J Bone Oncol. 2020. PMID: 33204608 Free PMC article.
Besides, miR-296-5p targeted zinc finger CCHC-type containing 3 (ZCCHC3), and FOXD3-AS1 released ZCCHC3 via sequestering miR-296-5p. Moreover, rescue assays delineated that ZCCHC3 upregulation neutralized the inhibitory effect of FOXD3-AS1 depletion on in vit …
Besides, miR-296-5p targeted zinc finger CCHC-type containing 3 (ZCCHC3), and FOXD3-AS1 released ZCCHC3 via sequestering miR-2 …
Host Zinc-finger CCHC-type containing protein 3 inhibits pseudorabies virus proliferation by regulating type I interferon signaling.
Chen X, Shan T, Sun D, Zhai H, Dong S, Kong N, Zheng H, Tong W, Tong G. Chen X, et al. Gene. 2022 Jun 15;827:146480. doi: 10.1016/j.gene.2022.146480. Epub 2022 Apr 4. Gene. 2022. PMID: 35390445
Here, we investigated the role of porcine ZCCHC3 during pseudorabies virus (PRV) proliferation. We found that porcine ZCCHC3 plays an inhibitory role in the proliferation of PRV by regulating cellular innate immune responses. Further, overexpression of ZCCHC3 …
Here, we investigated the role of porcine ZCCHC3 during pseudorabies virus (PRV) proliferation. We found that porcine ZCCHC3 p …
Proteomic analysis reveals zinc-finger CCHC-type containing protein 3 as a factor inhibiting virus infection by promoting innate signaling.
Chen X, Li Z, Wang S, Tong G, Chen K, Zhao Y. Chen X, et al. Virus Res. 2022 Oct 2;319:198876. doi: 10.1016/j.virusres.2022.198876. Epub 2022 Jul 22. Virus Res. 2022. PMID: 35872280 Free PMC article.
Western blotting and quantitative real-time PCR results showed that the zinc-finger CCHC-type containing protein 3 (ZCCHC3) levels were markedly induced by H9N2 infection. Transient expression assay showed that ZCCHC3 expression decreased NP protein levels and viral …
Western blotting and quantitative real-time PCR results showed that the zinc-finger CCHC-type containing protein 3 (ZCCHC3) levels we …
15 results