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BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Ghouil R, Miron S, Koornneef L, Veerman J, Paul MW, Le Du MH, Sleddens-Linkels E, van Rossum-Fikkert SE, van Loon Y, Felipe-Medina N, Pendas AM, Maas A, Essers J, Legrand P, Baarends WM, Kanaar R, Zinn-Justin S, Zelensky AN. Ghouil R, et al. Among authors: zelensky an. Nat Commun. 2021 Jul 29;12(1):4605. doi: 10.1038/s41467-021-24871-6. Nat Commun. 2021. PMID: 34326328 Free PMC article.
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, Ten Hagen TL, Kanaar R, Aten JA. Krawczyk PM, et al. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9851-6. doi: 10.1073/pnas.1101053108. Epub 2011 May 9. Proc Natl Acad Sci U S A. 2011. PMID: 21555554 Free PMC article.
Mediators of homologous DNA pairing.
Zelensky A, Kanaar R, Wyman C. Zelensky A, et al. Cold Spring Harb Perspect Biol. 2014 Oct 9;6(12):a016451. doi: 10.1101/cshperspect.a016451. Cold Spring Harb Perspect Biol. 2014. PMID: 25301930 Free PMC article. Review.
On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation.
van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R. van den Tempel N, et al. Among authors: zelensky an. Cancers (Basel). 2019 Jan 15;11(1):97. doi: 10.3390/cancers11010097. Cancers (Basel). 2019. PMID: 30650591 Free PMC article.
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Brandsma I, Sato K, van Rossum-Fikkert SE, van Vliet N, Sleddens E, Reuter M, Odijk H, van den Tempel N, Dekkers DHW, Bezstarosti K, Demmers JAA, Maas A, Lebbink J, Wyman C, Essers J, van Gent DC, Baarends WM, Knipscheer P, Kanaar R, Zelensky AN. Brandsma I, et al. Among authors: zelensky an. Cell Rep. 2019 Jun 25;27(13):3790-3798.e7. doi: 10.1016/j.celrep.2019.05.096. Cell Rep. 2019. PMID: 31242413 Free article.
20 results