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B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
Kaemena DF, Yoshihara M, Beniazza M, Ashmore J, Zhao S, Bertenstam M, Olariu V, Katayama S, Okita K, Tomlinson SR, Yusa K, Kaji K. Kaemena DF, et al. Nat Commun. 2023 Jan 30;14(1):488. doi: 10.1038/s41467-023-36097-9. Nat Commun. 2023. PMID: 36717582 Free PMC article.
We show that ZFP266 binds Short Interspersed Nuclear Elements (SINEs) adjacent to binding sites of pioneering factors, OCT4 (POU5F1), SOX2, and KLF4, and impedes chromatin opening. Replacing the KRAB co-suppressor with co-activator domains converts ZFP266 from an in …
We show that ZFP266 binds Short Interspersed Nuclear Elements (SINEs) adjacent to binding sites of pioneering factors, OCT4 (POU5F1), …
The Emerging Role of B1 SINE in Pluripotent Reprogramming.
Weltner J, Trokovic R. Weltner J, et al. Cell Reprogram. 2023 Jun;25(3):88-90. doi: 10.1089/cell.2023.0037. Epub 2023 May 8. Cell Reprogram. 2023. PMID: 37155628
By screening a CRISPR knockout library for mouse pluripotent reprogramming roadblock genes, Kaemena et al. identify the KRAB-ZFP factor Zfp266 as a suppressor of efficient reprogramming. Furthermore, by analyzing DNA binding and chromatin openness, the authors found that …
By screening a CRISPR knockout library for mouse pluripotent reprogramming roadblock genes, Kaemena et al. identify the KRAB-ZFP factor Z …