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A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.
Li X, Jiang Q, Song G, Barkestani MN, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober JS, Jane-Wit D. Li X, et al. Nat Commun. 2023 May 24;14(1):3002. doi: 10.1038/s41467-023-38684-2. Nat Commun. 2023. PMID: 37225719 Free PMC article.
ZFVYE21, a Rab5 effector, partners with Rubicon and RNF34, forming a "ZRR" complex that is stabilized in a Rab5- and ZFYVE21-dependent manner on early endosomes. There, Rubicon competitively disrupts inhibitory associations between caspase-1 and its pseudosubstrate, Flight …
ZFVYE21, a Rab5 effector, partners with Rubicon and RNF34, forming a "ZRR" complex that is stabilized in a Rab5- and ZFYVE21-dependen …
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
Jiang B, Wang S, Song G, Jiang Q, Fan M, Fang C, Li X, Soh CL, Manes TD, Cheru N, Qin L, Ren P, Jortner B, Wang Q, Quaranta E, Yoo P, Geirsson A, Davis RP, Tellides G, Pober JS, Jane-Wit D. Jiang B, et al. Sci Signal. 2023 Mar 21;16(777):eabo3406. doi: 10.1126/scisignal.abo3406. Epub 2023 Mar 21. Sci Signal. 2023. PMID: 36943921 Free PMC article.
The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse models, primary human cells, and patient samples, we identified a T cell-autonomous role for ZFYVE21 in promoting chronic vascular inflammation associated with allograft vasculopa …
The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse models, primary human cells, and patient sampl …
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-kappaB via phosphoinosotide remodeling of endosomes.
Fang C, Manes TD, Liu L, Liu K, Qin L, Li G, Tobiasova Z, Kirkiles-Smith NC, Patel M, Merola J, Fu W, Liu R, Xie C, Tietjen GT, Nigrovic PA, Tellides G, Pober JS, Jane-Wit D. Fang C, et al. Nat Commun. 2019 May 21;10(1):2247. doi: 10.1038/s41467-019-10041-2. Nat Commun. 2019. PMID: 31113953 Free PMC article.
ZFYVE21 induction distinctly occurs in response to MAC and is detected in human renal and synovial tissues. Our data identifies ZFYVE21 as a Rab5 effector, defines a Rab5-ZFYVE21-SMURF2-pAkt axis by which it mediates EC activation, and demonstrates a role for …
ZFYVE21 induction distinctly occurs in response to MAC and is detected in human renal and synovial tissues. Our data identifies ZF …
ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani MN, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin JE, Sessa WC, Ishibe S, Jane-Wit D. Jiang Q, et al. Kidney Int. 2024 May 24:S0085-2538(24)00342-9. doi: 10.1016/j.kint.2024.05.007. Online ahead of print. Kidney Int. 2024. PMID: 38797325 Free article.
ZFYVE21 levels significantly decline in ECs in aged human and mouse kidneys. ...ZFYVE21-mediated phenotypes were not programmed developmentally as loss of ZFYVE21 in ECs during adulthood phenocopied its loss prenatally, and a nitric oxide donor normalized kid …
ZFYVE21 levels significantly decline in ECs in aged human and mouse kidneys. ...ZFYVE21-mediated phenotypes were not programme …
Litter Size of Sheep (Ovis aries): Inbreeding Depression and Homozygous Regions.
Tao L, He X, Wang X, Di R, Chu M. Tao L, et al. Genes (Basel). 2021 Jan 18;12(1):109. doi: 10.3390/genes12010109. Genes (Basel). 2021. PMID: 33477586 Free PMC article.
Nine significantly homozygous regions were found for LS in Hu sheep, where some promising genes for LS possibly via regulation of the development of oocytes (NGF, AKT1, and SYCP1), fertilization (SPAG17, MORC1, TDRD9, ZFYVE21, ADGRB3, and CKB), embryo implantation (PPP1R13 …
Nine significantly homozygous regions were found for LS in Hu sheep, where some promising genes for LS possibly via regulation of the develo …
Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.
Figl A, Scherer D, Nagore E, Bermejo JL, Botella-Estrada R, Gast A, Thirumaran RK, Planelles D, Hemminki K, Schadendorf D, Kumar R. Figl A, et al. Mutat Res. 2010 Sep 30;702(1):8-16. doi: 10.1016/j.mrgentox.2010.06.011. Epub 2010 Jun 26. Mutat Res. 2010. PMID: 20601096
Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. ...
Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 …
19 results