The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL.
Zhang F, et al.
Chem Res Toxicol. 1999 Feb;12(2):204-13. doi: 10.1021/tx980217v.
Chem Res Toxicol. 1999.
PMID: 10027800
Previously, we showed that equilenin, a minor component of Premarin (Wyeth-Ayerst), was metabolized to highly cytotoxic quinoids which caused oxidative stress and alkylation of DNA in vitro [Bolton, J. L., Pisha, E., Zhang, F., and Qiu, S. (1998) Chem. Res. Toxicol. …
Previously, we showed that equilenin, a minor component of Premarin (Wyeth-Ayerst), was metabolized to highly cytotoxic quinoids which cause …