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Role of quinoids in estrogen carcinogenesis.
Bolton JL, Pisha E, Zhang F, Qiu S. Bolton JL, et al. Among authors: zhang f. Chem Res Toxicol. 1998 Oct;11(10):1113-27. doi: 10.1021/tx9801007. Chem Res Toxicol. 1998. PMID: 9778307 Review. No abstract available.
The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. Zhang F, et al. Chem Res Toxicol. 1999 Feb;12(2):204-13. doi: 10.1021/tx980217v. Chem Res Toxicol. 1999. PMID: 10027800
Previously, we showed that equilenin, a minor component of Premarin (Wyeth-Ayerst), was metabolized to highly cytotoxic quinoids which caused oxidative stress and alkylation of DNA in vitro [Bolton, J. L., Pisha, E., Zhang, F., and Qiu, S. (1998) Chem. Res. Toxicol. …
Previously, we showed that equilenin, a minor component of Premarin (Wyeth-Ayerst), was metabolized to highly cytotoxic quinoids which cause …
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