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Quantitative protein profiling of hippocampus during human aging.
Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai WP, Huang Y, Yan XX, Ge W, Ma C. Xu B, et al. Neurobiol Aging. 2016 Mar;39:46-56. doi: 10.1016/j.neurobiolaging.2015.11.029. Epub 2015 Dec 8. Neurobiol Aging. 2016. PMID: 26923401
Using the 4-plex tandem mass tag labeling, we carried out a quantitative proteomic study of the hippocampus during normal aging using postmortem brains from Chinese subjects. Hippocampal samples from 16 subjects died of non-neurological/psychiatric diseases were div …
Using the 4-plex tandem mass tag labeling, we carried out a quantitative proteomic study of the hippocampus during normal aging using …
Ghrelin inhibits proinflammatory responses and prevents cognitive impairment in septic rats.
Wei H, Cao X, Zeng Q, Zhang F, Xue Q, Luo Y, Lee JW, Yu B, Feng X. Wei H, et al. Crit Care Med. 2015 May;43(5):e143-50. doi: 10.1097/CCM.0000000000000930. Crit Care Med. 2015. PMID: 25756415
Animals were randomly divided into four groups: sham, sham + ghrelin, cecal ligation and puncture, and cecal ligation and puncture + ghrelin. Saline was given subcutaneously (30 mL/kg) at 4 and 16 hours after surgery for all rats. Septic rats were treated with ceftriaxone …
Animals were randomly divided into four groups: sham, sham + ghrelin, cecal ligation and puncture, and cecal ligation and puncture + ghrelin …
P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity.
Zhou P, Zhang Y, Xu H, Chen F, Chen X, Li X, Pi X, Wang L, Zhan L, Nan F, Gao Z. Zhou P, et al. Mol Pharmacol. 2015 Jan;87(1):31-8. doi: 10.1124/mol.114.095190. Epub 2014 Oct 15. Mol Pharmacol. 2015. PMID: 25319542
The brain-to-plasma concentration ratio of P-RTG increased to 2.30 compared with 0.16 for RTG. However, the structural modification did not change the drug's potentiation potency, subtype selectivity, or RTG molecular determinants on KCNQ channels. ...
The brain-to-plasma concentration ratio of P-RTG increased to 2.30 compared with 0.16 for RTG. However, the structural modification d …
Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity.
Zhang Z, Wang W, Zhong P, Liu SJ, Long JZ, Zhao L, Gao HQ, Cravatt BF, Liu QS. Zhang Z, et al. Hippocampus. 2015 Jan;25(1):16-26. doi: 10.1002/hipo.22344. Epub 2014 Aug 27. Hippocampus. 2015. PMID: 25131612 Free PMC article.
We tested whether CUS and chronic JZL184 treatments affected adult neurogenesis and synaptic plasticity in the dentate gyrus (DG) of mouse hippocampus. We report that CUS induced depressive-like behaviors and decreased the number of bromodeoxyuridine-labeled neural progeni …
We tested whether CUS and chronic JZL184 treatments affected adult neurogenesis and synaptic plasticity in the dentate gyrus (DG) of mouse …
[Anti-dementia effect of Tongluo Xingnao effervescent tablet based on urinary metabonomics].
Wei JP, Zhang YJ, Ma YT, Xu SJ, Wang YY. Wei JP, et al. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3287-92. Zhongguo Zhong Yao Za Zhi. 2015. PMID: 26790309 Chinese.
The experiment indicates that the dementia model induced by injecting Abeta25-3 into hippocampus has its characteristic endogenous metabolic markers in urine, and ELXNET can ameliorate dementia by down-regulating the disturbances of metabolic trajectory....
The experiment indicates that the dementia model induced by injecting Abeta25-3 into hippocampus has its characteristic endogenous me …