Zhu R - Search Results

1

Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies.

Zhu R, Lu D, Chu YW, Chai A, Green M, Zhang N, Jin JY. Zhu R, et al. AAPS J. 2017 May;19(3):669-681. doi: 10.1208/s12248-017-0056-x. Epub 2017 Feb 21. AAPS J. 2017. PMID: 28224402 Review.

2

Population-based efficacy modeling of omalizumab in patients with severe allergic asthma inadequately controlled with standard therapy.

Zhu R, Zheng Y, Putnam WS, Visich J, Eisner MD, Matthews JG, Rosen KE, D'Argenio DZ. Zhu R, et al. AAPS J. 2013 Apr;15(2):559-70. doi: 10.1208/s12248-013-9463-9. Epub 2013 Feb 15. AAPS J. 2013. PMID: 23413101 Free PMC article. Clinical Trial.

3

Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis.

Wang Y, Zhu R, Xiao J, Davis JC Jr, Mandema JW, Jin JY, Tang MT. Wang Y, et al. Among authors: zhu r. J Clin Pharmacol. 2016 Jul;56(7):835-44. doi: 10.1002/jcph.668. Epub 2015 Dec 31. J Clin Pharmacol. 2016. PMID: 26517752 Free PMC article.

4

Model-based clinical pharmacology profiling and exposure-response relationships of the efficacy and biomarker of lebrikizumab in patients with moderate-to-severe asthma.

Zhu R, Zheng Y, Dirks NL, Vadhavkar S, Jin JY, Peng K, Holweg CTJ, Olsson J, Matthews JG, Putnam WS. Zhu R, et al. Pulm Pharmacol Ther. 2017 Oct;46:88-98. doi: 10.1016/j.pupt.2017.08.010. Epub 2017 Aug 24. Pulm Pharmacol Ther. 2017. PMID: 28843617 Free article.

5

Exposure-Response-Based Product Profile-Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer.

Zhu R, Poland B, Wada R, Liu Q, Musib L, Maslyar D, Cho E, Yu W, Ma H, Jin JY, Budha N. Zhu R, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Apr;8(4):240-248. doi: 10.1002/psp4.12394. Epub 2019 Mar 6. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30762302 Free PMC article.

6

Population repeated time-to-event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires.

Svensson RJ, Ribbing J, Kotani N, Dolton M, Vadhavkar S, Cheung D, Staton T, Choy DF, Putnam W, Jin J, Budha N, Karlsson MO, Quartino A, Zhu R. Svensson RJ, et al. Among authors: zhu r. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1221-1235. doi: 10.1002/psp4.12690. Epub 2021 Aug 5. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34346168 Free PMC article. Clinical Trial.

7

Population-Based Pharmacodynamic Modeling of Omalizumab in Pediatric Patients with Moderate to Severe Persistent Inadequately Controlled Allergic Asthma.

Zhu R, Wang X, Anderson E, Deng M, Pivirotto S, Jin J, Kassir N, Owen R. Zhu R, et al. AAPS J. 2023 Jun 2;25(4):56. doi: 10.1208/s12248-023-00823-4. AAPS J. 2023. PMID: 37266853

8

Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma.

Powles T, Lackner MR, Oudard S, Escudier B, Ralph C, Brown JE, Hawkins RE, Castellano D, Rini BI, Staehler MD, Ravaud A, Lin W, O'Keeffe B, Wang Y, Lu S, Spoerke JM, Huw LY, Byrtek M, Zhu R, Ware JA, Motzer RJ. Powles T, et al. Among authors: zhu r. J Clin Oncol. 2016 May 10;34(14):1660-8. doi: 10.1200/JCO.2015.64.8808. Epub 2016 Mar 7. J Clin Oncol. 2016. PMID: 26951309 Free PMC article. Clinical Trial.

9

Pharmacokinetics and exposure-efficacy relationships of omalizumab in patients with nasal polyps.

Zhu R, Owen R, Wilkins J, Schoemaker R, Tian X, Gautier A, She G, Vadhavkar S, Cheu M, Wong K, Omachi TA, Putnam WS, Quartino AL. Zhu R, et al. Pulm Pharmacol Ther. 2021 Dec;71:102080. doi: 10.1016/j.pupt.2021.102080. Epub 2021 Sep 28. Pulm Pharmacol Ther. 2021. PMID: 34592476 Free article.

10

A longitudinal model for the Mayo Clinical Score and its sub-components in patients with ulcerative colitis.

Kawakatsu S, Zhu R, Zhang W, Tang MT, Lu T, Quartino AL, Kågedal M. Kawakatsu S, et al. Among authors: zhu r. J Pharmacokinet Pharmacodyn. 2022 Apr;49(2):179-190. doi: 10.1007/s10928-021-09789-2. Epub 2021 Oct 16. J Pharmacokinet Pharmacodyn. 2022. PMID: 34657238 Free PMC article.

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