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Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.
Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E. Horwitz E, et al. Among authors: zreik f. Cancer Discov. 2014 Jun;4(6):730-43. doi: 10.1158/2159-8290.CD-13-0782. Epub 2014 Mar 31. Cancer Discov. 2014. PMID: 24687604
Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.
Hefetz-Sela S, Stein I, Klieger Y, Porat R, Sade-Feldman M, Zreik F, Nagler A, Pappo O, Quagliata L, Dazert E, Eferl R, Terracciano L, Wagner EF, Ben-Neriah Y, Baniyash M, Pikarsky E. Hefetz-Sela S, et al. Among authors: zreik f. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17582-7. doi: 10.1073/pnas.1409700111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422452 Free PMC article.
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Biton M, Levin A, Slyper M, Alkalay I, Horwitz E, Mor H, Kredo-Russo S, Avnit-Sagi T, Cojocaru G, Zreik F, Bentwich Z, Poy MN, Artis D, Walker MD, Hornstein E, Pikarsky E, Ben-Neriah Y. Biton M, et al. Among authors: zreik f. Nat Immunol. 2011 Mar;12(3):239-46. doi: 10.1038/ni.1994. Epub 2011 Jan 30. Nat Immunol. 2011. PMID: 21278735