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ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome.
Andersen A, Milefchik E, Papworth E, Penaluna B, Dawes K, Moody J, Weeks G, Froehlich E, deBlois K, Long JD, Philibert R. Andersen A, et al. Epigenetics. 2024 Dec;19(1):2298057. doi: 10.1080/15592294.2023.2298057. Epub 2024 Jan 3. Epigenetics. 2024. PMID: 38166538 Free PMC article.
We found that PAWSS did not significantly predict severe AWS nor seizures. However, methylation at cg07375256 (ZSCAN25) and CDT strongly predicted severe AWS with ATS (p < 0.007) and cg07375256 (p < 6 10-5) methylation also predicting AWS associated seizures. ...
We found that PAWSS did not significantly predict severe AWS nor seizures. However, methylation at cg07375256 (ZSCAN25) and CDT stron …
Metabolomic architecture of obesity implicates metabolonic lactone sulfate in cardiometabolic disease.
Das SK, Ainsworth HC, Dimitrov L, Okut H, Comeau ME, Sharma N, Ng MCY, Norris JM, Chen YI, Wagenknecht LE, Bowden DW, Hsu FC, Taylor KD, Langefeld CD, Palmer ND. Das SK, et al. Mol Metab. 2021 Dec;54:101342. doi: 10.1016/j.molmet.2021.101342. Epub 2021 Sep 24. Mol Metab. 2021. PMID: 34563731 Free PMC article.
Metabolonic lactone sulfate levels were heritable (h(2) > 0.47), and a significant genetic signal at the ZSCAN25/CYP3A5 locus (P(MA) = 9.00 10(-41), P(AA) = 2.31 10(-10)) was observed, highlighting a putative functional variant (rs776746, CYP3A53). ...
Metabolonic lactone sulfate levels were heritable (h(2) > 0.47), and a significant genetic signal at the ZSCAN25/CYP3A5 locus (P(M …