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The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.
Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D. Cheng ZL, et al. Cell Rep. 2020 Jul 14;32(2):107877. doi: 10.1016/j.celrep.2020.107877. Cell Rep. 2020. PMID: 32668244 Free article.
The Zscan4f-Tet2 interaction promotes DNA demethylation and regulates the expression of target genes, particularly those encoding glycolytic enzymes and proteasome subunits. Zscan4f regulates metabolic rewiring, enhances proteasome function, and ultimately promotes …
The Zscan4f-Tet2 interaction promotes DNA demethylation and regulates the expression of target genes, particularly those encoding gly …
Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells.
Falco G, Lee SL, Stanghellini I, Bassey UC, Hamatani T, Ko MS. Falco G, et al. Dev Biol. 2007 Jul 15;307(2):539-50. doi: 10.1016/j.ydbio.2007.05.003. Epub 2007 May 8. Dev Biol. 2007. PMID: 17553482 Free PMC article.
Three genes are not transcribed and are thus considered pseudogenes. Among the six expressed genes named Zscan4a-Zscan4f, three - Zscan4c, Zscan4d, and Zscan4f - encode full-length ORFs with 506 amino acids. ...
Three genes are not transcribed and are thus considered pseudogenes. Among the six expressed genes named Zscan4a-Zscan4f, three - Zsc …
Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.
Storm MP, Kumpfmueller B, Bone HK, Buchholz M, Sanchez Ripoll Y, Chaudhuri JB, Niwa H, Tosh D, Welham MJ. Storm MP, et al. PLoS One. 2014 Mar 3;9(3):e89821. doi: 10.1371/journal.pone.0089821. eCollection 2014. PLoS One. 2014. PMID: 24594919 Free PMC article.
Here we show that undifferentiated mouse embryonic stem cell (ESC) lines simultaneously express multiple members of the Zscan4 gene family, with Zscan4c, Zscan4f and Zscan4-ps2 consistently being the most abundant. Despite this, between only 0.1 and 0.7% of undifferentiate …
Here we show that undifferentiated mouse embryonic stem cell (ESC) lines simultaneously express multiple members of the Zscan4 gene family, …