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ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling.
Mao Y, Jiang X, Guo P, Ouyang Y, Chen X, Xia M, Wu L, Tang Z, Liang T, Li Y, He M. Mao Y, et al. iScience. 2023 Jul 20;26(8):107447. doi: 10.1016/j.isci.2023.107447. eCollection 2023 Aug 18. iScience. 2023. PMID: 37599824 Free PMC article.
We observed that overexpression of ZXDC promotes, while silencing of ZXDC inhibits the metastasis of CC cells both in vitro and in vivo. ...These findings reveal a mechanism whereby ZXDC promotes the cervical cancer metastasis by targeting IGF2BP3/RhoA/ROCK p …
We observed that overexpression of ZXDC promotes, while silencing of ZXDC inhibits the metastasis of CC cells both in vitro an …
ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.
Al-Kandari W, Jambunathan S, Navalgund V, Koneni R, Freer M, Parimi N, Mudhasani R, Fontes JD. Al-Kandari W, et al. Mol Immunol. 2007 Jan;44(4):311-21. doi: 10.1016/j.molimm.2006.02.029. Epub 2006 Apr 4. Mol Immunol. 2007. PMID: 16600381 Free PMC article.
Conversely, silencing of ZXDC expression reduced the ability of CIITA to activate transcription of MHC class II genes. Given the specific interaction between the ZXDC and CIITA proteins, as well as the effect of ZXDC on MHC gene transcription, it appears that …
Conversely, silencing of ZXDC expression reduced the ability of CIITA to activate transcription of MHC class II genes. Given the spec …
Pan-primate studies of age and sex.
Horvath S, Haghani A, Zoller JA, Lu AT, Ernst J, Pellegrini M, Jasinska AJ, Mattison JA, Salmon AB, Raj K, Horvath M, Paul KC, Ritz BR, Robeck TR, Spriggs M, Ehmke EE, Jenkins S, Li C, Nathanielsz PW. Horvath S, et al. Geroscience. 2023 Dec;45(6):3187-3209. doi: 10.1007/s11357-023-00878-3. Epub 2023 Jul 26. Geroscience. 2023. PMID: 37493860 Free PMC article.
We identify 11 sex-related CpGs on autosomes near genes (POU3F2, CDYL, MYCL, FBXL4, ZC3H10, ZXDC, RRAS, FAM217A, RBM39, GRIA2, UHRF2). Low overlap can be observed between age- and sex-related CpGs. ...
We identify 11 sex-related CpGs on autosomes near genes (POU3F2, CDYL, MYCL, FBXL4, ZC3H10, ZXDC, RRAS, FAM217A, RBM39, GRIA2, UHRF2) …
Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.
Jambunathan S, Fontes JD. Jambunathan S, et al. Biol Chem. 2007 Sep;388(9):965-72. doi: 10.1515/BC.2007.106. Biol Chem. 2007. PMID: 17696781
Multiple SUMO E3 ligase enzymes and HDAC4 can facilitate ZXDC sumoylation, and one ligase, PIASy, interacts with a specific region of the ZXDC protein. ...Our findings suggest that sumoylation is an important regulator of ZXDC....
Multiple SUMO E3 ligase enzymes and HDAC4 can facilitate ZXDC sumoylation, and one ligase, PIASy, interacts with a specific region of …
An eQTL variant of ZXDC is associated with IFN-gamma production following Mycobacterium tuberculosis antigen-specific stimulation.
Jabot-Hanin F, Cobat A, Feinberg J, Orlova M, Niay J, Deswarte C, Poirier C, Theodorou I, Bustamante J, Boisson-Dupuis S, Casanova JL, Alcaïs A, Hoal EG, Delacourt C, Schurr E, Abel L. Jabot-Hanin F, et al. Sci Rep. 2017 Oct 9;7(1):12800. doi: 10.1038/s41598-017-13017-8. Sci Rep. 2017. PMID: 28993696 Free PMC article.

This variant made a significant contribution to the linkage signal (p < 0.001), and a trend towards the same association was observed in the South African sample. This variant was reported to be an eQTL of the ZXDC gene, biologically linked to monocyte IL-12 production

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This variant made a significant contribution to the linkage signal (p < 0.001), and a trend towards the same association was observed in

…
The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.
Al-Kandari W, Koneni R, Navalgund V, Aleksandrova A, Jambunathan S, Fontes JD. Al-Kandari W, et al. J Mol Biol. 2007 Jun 22;369(5):1175-87. doi: 10.1016/j.jmb.2007.04.033. Epub 2007 Apr 19. J Mol Biol. 2007. PMID: 17493635 Free PMC article.
Here, we examined the contribution of a closely related family member of ZXDC, the ZXDA protein, to MHC II gene transcription. ZXDA has a domain organization similar to ZXDC, containing ten zinc fingers and a transcriptional activation domain. ...Given our additiona …
Here, we examined the contribution of a closely related family member of ZXDC, the ZXDA protein, to MHC II gene transcription. ZXDA h …
The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression.
Ramsey JE, Fontes JD. Ramsey JE, et al. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. Mol Immunol. 2013. PMID: 23954399 Free PMC article.
The expression of one gene in this family, ZXD family zinc finger C (ZXDC), is enriched in myeloid lineages and therefore we hypothesized that ZXDC may regulate myeloid-specific gene expression. Here we demonstrate that ZXDC regulates genes involved in myeloi …
The expression of one gene in this family, ZXD family zinc finger C (ZXDC), is enriched in myeloid lineages and therefore we hypothes …
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy.
Rivedal M, Mikkelsen H, Marti HP, Liu L, Kiryluk K, Knoop T, Bjørneklett R, Haaskjold YL, Furriol J, Leh S, Paunas F, Bábíčková J, Scherer A, Serre C, Eikrem O, Strauss P. Rivedal M, et al. Kidney Int. 2024 Apr;105(4):717-730. doi: 10.1016/j.kint.2023.12.010. Epub 2023 Dec 26. Kidney Int. 2024. PMID: 38154557 Free article.
Based on 1 240 differentially expressed genes from patients with suitable sequencing results, we identified eight IgAN progressor and nine non-progressor genes using a two-component classifier. These genes, including APOL5 and ZXDC, predicted disease progression with 88% a …
Based on 1 240 differentially expressed genes from patients with suitable sequencing results, we identified eight IgAN progressor and nine n …
An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.
Aleksandrova A, Galkin O, Koneni R, Fontes JD. Aleksandrova A, et al. Mol Cell Biochem. 2010 Apr;337(1-2):1-7. doi: 10.1007/s11010-009-0280-5. Epub 2009 Sep 24. Mol Cell Biochem. 2010. PMID: 19777325 Free PMC article.
Aside from the full length ZXDC mRNA transcript, at least one additional mRNA is produced by the ZXDC gene, in which transcription initiates within the first exon and terminates within the seventh intron. ...We further demonstrate that ZXDC2 interacts with both ZXDA …
Aside from the full length ZXDC mRNA transcript, at least one additional mRNA is produced by the ZXDC gene, in which transcrip …
14 results