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Page 1
Defective intestinal amino acid absorption in Ace2 null mice.
Singer D, Camargo SM, Ramadan T, Schäfer M, Mariotta L, Herzog B, Huggel K, Wolfer D, Werner S, Penninger JM, Verrey F. Singer D, et al. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G686-95. doi: 10.1152/ajpgi.00140.2012. Epub 2012 Jul 12. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22790597 Free article.
These latter symptoms caused by low-niacin are thought to result from defective intestinal absorption of its precursor L-tryptophan. Since Ace2 is necessary for intestinal B(0)AT1 expression, we tested the impact of intestinal B(0)AT1 absence in ace2 null mic …
These latter symptoms caused by low-niacin are thought to result from defective intestinal absorption of its precursor L-tryptophan. Since …
The role of ACE2 in cardiovascular physiology.
Oudit GY, Crackower MA, Backx PH, Penninger JM. Oudit GY, et al. Trends Cardiovasc Med. 2003 Apr;13(3):93-101. doi: 10.1016/s1050-1738(02)00233-5. Trends Cardiovasc Med. 2003. PMID: 12691672 Review.
In these animal models, kidney ACE2 messenger RNA and protein expression were markedly reduced, making ACE2 a candidate gene for this QTL. ...Genetic ablation of ACE in the ACE2 null mice rescued the cardiac phenotype. These genetic data show that A …
In these animal models, kidney ACE2 messenger RNA and protein expression were markedly reduced, making ACE2 a candidate gene f …
Exosome-Mediated Transfer of ACE2 (Angiotensin-Converting Enzyme 2) from Endothelial Progenitor Cells Promotes Survival and Function of Endothelial Cell.
Wang J, Chen S, Bihl J. Wang J, et al. Oxid Med Cell Longev. 2020 Jan 18;2020:4213541. doi: 10.1155/2020/4213541. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32051731 Free PMC article.
Human EPCs were transfected with lentivirus containing null or human ACE2 cDNA (denoted as Null-EPCs and ACE2-EPCs, respectively). Their conditioned culture media, w/wo depletion of exosomes (ACE2-EPC-CM(EX-), Null-EPC-CM(EX-), ACE2 …
Human EPCs were transfected with lentivirus containing null or human ACE2 cDNA (denoted as Null-EPCs and ACE2-EP …
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.
Gurley SB, Allred A, Le TH, Griffiths R, Mao L, Philip N, Haystead TA, Donoghue M, Breitbart RE, Acton SL, Rockman HA, Coffman TM. Gurley SB, et al. J Clin Invest. 2006 Aug;116(8):2218-25. doi: 10.1172/JCI16980. Epub 2006 Jul 27. J Clin Invest. 2006. PMID: 16878172 Free PMC article.
The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To clarify the physiological roles of ACE2, we generated mice with targeted disruption of the Ace2 gene. ...On the C57BL/6 background, ACE2 deficiency was associated with …
The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To clarify the physiological roles of ACE2, w …
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity.
Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY. Patel VB, et al. Diabetes. 2016 Jan;65(1):85-95. doi: 10.2337/db15-0399. Epub 2015 Jul 29. Diabetes. 2016. PMID: 26224885 Free PMC article.
We studied the role of ACE2 in obesity-mediated cardiac dysfunction. ACE2 null (ACE2KO) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet and studied at 6 months of age. ...Ang 1-7 (24 g/kg/h) administered to ACE2KO-HFD mice resulted in …
We studied the role of ACE2 in obesity-mediated cardiac dysfunction. ACE2 null (ACE2KO) and wild-type (WT) mice were fe …
Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.
Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY. Bodiga S, et al. Cardiovasc Res. 2011 Jul 1;91(1):151-61. doi: 10.1093/cvr/cvr036. Epub 2011 Feb 1. Cardiovasc Res. 2011. PMID: 21285291 Free PMC article.
Loss of ACE2 enhances the susceptibility to heart disease but the mechanism remains elusive. ...METHODS AND RESULTS: Using the aortic constriction model, we subjected wild-type (Ace2(+/y)), ACE2 knockout (ACE2KO, Ace2(-/y)), p47(phox) knockout (p47(pho …
Loss of ACE2 enhances the susceptibility to heart disease but the mechanism remains elusive. ...METHODS AND RESULTS: Using the aortic …
Angiotensin-converting enzyme 2 in the brain: properties and future directions.
Xia H, Lazartigues E. Xia H, et al. J Neurochem. 2008 Dec;107(6):1482-94. doi: 10.1111/j.1471-4159.2008.05723.x. Epub 2008 Nov 5. J Neurochem. 2008. PMID: 19014390 Free PMC article. Review.
In addition, the expression level and/or activity are affected by other renin-angiotensin system components (e.g., ACE and AT1 receptors). Local inhibition or global deletion of brain ACE2 induces a reduction in baroreflex sensitivity. Moreover, ACE2-null mic …
In addition, the expression level and/or activity are affected by other renin-angiotensin system components (e.g., ACE and AT1 receptors). L …
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Fuchs E, Rudnik-Jansen I, Dinesen A, Selnihhin D, Mandrup OA, Thiam K, Kjems J, Pedersen FS, Howard KA. Fuchs E, et al. Acta Biomater. 2022 Nov;153:411-418. doi: 10.1016/j.actbio.2022.09.048. Epub 2022 Sep 24. Acta Biomater. 2022. PMID: 36162760 Free PMC article.
This work presents a recombinant human albumin ACE2 genetic fusion (rHA-ACE2) to increase the plasma half-life by an FcRn-driven cellular recycling mechanism, investigated using a wild type (WT) albumin sequence and sequence engineered with null FcRn binding …
This work presents a recombinant human albumin ACE2 genetic fusion (rHA-ACE2) to increase the plasma half-life by an FcRn-driv …
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Oudit GY, et al. Cardiovasc Res. 2007 Jul 1;75(1):29-39. doi: 10.1016/j.cardiores.2007.04.007. Epub 2007 Apr 21. Cardiovasc Res. 2007. PMID: 17499227
Current pharmacotherapies for human heart failure, such as ACE inhibitors and angiotensin and aldosterone receptor blockers, increase the activity of ACE2 in the heart. In this study, we investigate the mechanism for the age-dependent cardiomyopathy in ACE2 null …
Current pharmacotherapies for human heart failure, such as ACE inhibitors and angiotensin and aldosterone receptor blockers, increase the ac …
Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts.
MacCallum DM, Findon H, Kenny CC, Butler G, Haynes K, Odds FC. MacCallum DM, et al. Infect Immun. 2006 Sep;74(9):5244-8. doi: 10.1128/IAI.00817-06. Infect Immun. 2006. PMID: 16926418 Free PMC article.
In animals rendered temporarily neutropenic by cyclophosphamide treatment, the C. glabrata ace2 null mutant was confirmed as hypervirulent: it led to early terminal illness and kidney, brain, and lung fungal burdens substantially and significantly larger than those …
In animals rendered temporarily neutropenic by cyclophosphamide treatment, the C. glabrata ace2 null mutant was confirmed as h …
43 results