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Page 1
Showing results for acronine
Your search for acronize retrieved no results
Structure-activity relationship studies of new acronine analogues as suggested by molecular descriptors.
Neto MR, DaCosta JB, Sant'Anna CM, Carneiro JW. Neto MR, et al. Arzneimittelforschung. 2005;55(5):282-8. doi: 10.1055/s-0031-1296858. Arzneimittelforschung. 2005. PMID: 15960428
This work describes the results of an investigation on the structure-activity relationships of a series of acronine (CAS 7008-42-6) analogues which possess cytotoxic and antitumor activity. ...The best results, obtained with electrostatic descriptors, led to propose new st …
This work describes the results of an investigation on the structure-activity relationships of a series of acronine (CAS 7008-42-6) a …
Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine.
Bourne DW, Higuchi T, Repta AJ. Bourne DW, et al. J Pharm Sci. 1977 May;66(5):628-31. doi: 10.1002/jps.2600660505. J Pharm Sci. 1977. PMID: 17711
The low aqueous solubility of acronine (approximately 2 mg/liter) has been overcome by identification of quaternary prodrug salts exhibiting apparent molar solubilities two to five orders of magnitude greater than acronine. ...
The low aqueous solubility of acronine (approximately 2 mg/liter) has been overcome by identification of quaternary prodrug salts exh …
Acronycine derivatives: a promising series of anticancer agents.
Nguyen QC, Nguyen TT, Yougnia R, Gaslonde T, Dufat H, Michel S, Tillequin F. Nguyen QC, et al. Anticancer Agents Med Chem. 2009 Sep;9(7):804-15. doi: 10.2174/187152009789056921. Epub 2009 Sep 1. Anticancer Agents Med Chem. 2009. PMID: 19594412 Review.
Hydrolysis mechanism of 7-acetylacroninium perchlorate, a novel prodrug of acronine.
Repta AJ, Dimmock JR, Kreilgård B, Kaminski JJ. Repta AJ, et al. J Pharm Sci. 1977 Oct;66(10):1501-3. doi: 10.1002/jps.2600661045. J Pharm Sci. 1977. PMID: 925917
7-Acetylacroninium perchlorate was hydrolyzed at 25 degrees by both water enriched with 18O-labeled water and by unenriched water. The acronine obtained was examined by mass spectrometry, which indicated the unusual fact that hydrolysis of this ester proceeded by aryl oxyg …
7-Acetylacroninium perchlorate was hydrolyzed at 25 degrees by both water enriched with 18O-labeled water and by unenriched water. The ac …
Analysis of the prodrug 7-acetylacroninium perchlorate in presence of the parent compound acronine.
Hansen AB, Kreilgård B, Huang CH, Repta AJ. Hansen AB, et al. J Pharm Sci. 1978 Feb;67(2):237-9. doi: 10.1002/jps.2600670228. J Pharm Sci. 1978. PMID: 621645
Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivati …
Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts q …
Design of novel antitumor DNA alkylating agents: the benzacronycine series.
David-Cordonnier MH, Laine W, Gaslonde T, Michel S, Tillequin F, Koch M, Léonce S, Pierré A, Bailly C. David-Cordonnier MH, et al. Curr Med Chem Anticancer Agents. 2004 Mar;4(2):83-92. doi: 10.2174/1568011043482115. Curr Med Chem Anticancer Agents. 2004. PMID: 15032716 Review.
Microbial models for drug metabolism.
Rosazza JP, Smith RV. Rosazza JP, et al. Adv Appl Microbiol. 1979;25:169-208. doi: 10.1016/s0065-2164(08)70150-3. Adv Appl Microbiol. 1979. PMID: 397736 Review. No abstract available.
90 results