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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 5
1948 7
1949 12
1950 19
1951 28
1952 26
1953 10
1954 14
1955 14
1956 26
1957 15
1958 16
1959 17
1960 26
1961 25
1962 36
1963 38
1964 33
1965 35
1966 33
1967 41
1968 42
1969 47
1970 43
1971 94
1972 139
1973 146
1974 146
1975 278
1976 285
1977 320
1978 398
1979 441
1980 521
1981 591
1982 690
1983 764
1984 848
1985 905
1986 1120
1987 1016
1988 1149
1989 1396
1990 1554
1991 1723
1992 1777
1993 1976
1994 2041
1995 2175
1996 2374
1997 2627
1998 2844
1999 3073
2000 3250
2001 3317
2002 3597
2003 3846
2004 4110
2005 4516
2006 4754
2007 4945
2008 4940
2009 5114
2010 5368
2011 5591
2012 5847
2013 6019
2014 5894
2015 5803
2016 5615
2017 5312
2018 5500
2019 5355
2020 5578
2021 5586
2022 5007
2023 4775
2024 1758

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142,831 results

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Page 1
Actin structure and function.
Dominguez R, Holmes KC. Dominguez R, et al. Annu Rev Biophys. 2011;40:169-86. doi: 10.1146/annurev-biophys-042910-155359. Annu Rev Biophys. 2011. PMID: 21314430 Free PMC article. Review.
These properties, along with its ability to transition between monomeric (G-actin) and filamentous (F-actin) states under the control of nucleotide hydrolysis, ions, and a large number of actin-binding proteins, make actin a critical player in many cel …
These properties, along with its ability to transition between monomeric (G-actin) and filamentous (F-actin) states under the …
Actin and Actin-Binding Proteins.
Pollard TD. Pollard TD. Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8):a018226. doi: 10.1101/cshperspect.a018226. Cold Spring Harb Perspect Biol. 2016. PMID: 26988969 Free PMC article. Review.
Organisms from all domains of life depend on filaments of the protein actin to provide structure and to support internal movements. Many eukaryotic cells use forces produced by actin polymerization for their motility, and myosin motor proteins use ATP hydrolysis to …
Organisms from all domains of life depend on filaments of the protein actin to provide structure and to support internal movements. M …
Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration.
Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Bisaria A, et al. Science. 2020 Jun 12;368(6496):1205-1210. doi: 10.1126/science.aay7794. Science. 2020. PMID: 32527825 Free PMC article.
Cell migration is driven by local membrane protrusion through directed polymerization of F-actin at the front. However, F-actin next to the plasma membrane also tethers the membrane and thus resists outgoing protrusions. Here, we developed a fluorescent reporter to …
Cell migration is driven by local membrane protrusion through directed polymerization of F-actin at the front. However, F-actin …
Membrane bending by actin polymerization.
Carlsson AE. Carlsson AE. Curr Opin Cell Biol. 2018 Feb;50:1-7. doi: 10.1016/j.ceb.2017.11.007. Epub 2017 Dec 5. Curr Opin Cell Biol. 2018. PMID: 29207306 Free PMC article. Review.
In endocytosis, actin polymerization is especially important under conditions of high membrane tension or high turgor pressure. Recent modeling efforts have shown how actin polymerization can give rise to a distribution of forces around the endocytic site, and explo …
In endocytosis, actin polymerization is especially important under conditions of high membrane tension or high turgor pressure. Recen …
The actin slingshot.
Plastino J, Sykes C. Plastino J, et al. Curr Opin Cell Biol. 2005 Feb;17(1):62-6. doi: 10.1016/j.ceb.2004.12.001. Curr Opin Cell Biol. 2005. PMID: 15661520 Review.
Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. ...Recent experimental developments and associated theoretical models have provided us with a better understanding of motilit …
Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria wi …
Posttranscriptional and Posttranslational Regulation of Actin.
Rodriguez A, Kashina A. Rodriguez A, et al. Anat Rec (Hoboken). 2018 Dec;301(12):1991-1998. doi: 10.1002/ar.23958. Epub 2018 Nov 19. Anat Rec (Hoboken). 2018. PMID: 30312009 Free PMC article. Review.
Moreover, a study published this year suggests that actin's essential roles at the organismal level may be entirely nucleotide-dependent. This review summarizes the emerging data on actin's nucleotide-level regulation. Anat Rec, 301:1991-1998, 2018. 20 …
Moreover, a study published this year suggests that actin's essential roles at the organismal level may be entirely nucleotide …
Actin's prokaryotic homologs.
Egelman EH. Egelman EH. Curr Opin Struct Biol. 2003 Apr;13(2):244-8. doi: 10.1016/s0959-440x(03)00027-7. Curr Opin Struct Biol. 2003. PMID: 12727519 Review.
Whereas the eukaryotic actins display a remarkable degree of conservation (e.g. no amino acid changes in muscle actin from chickens to humans), the two bacterial proteins have as much sequence similarity to each other ( approximately 11% sequence identity) as they d …
Whereas the eukaryotic actins display a remarkable degree of conservation (e.g. no amino acid changes in muscle actin from chi …
Fundamental differences.
Gunning PW, Hardeman EC. Gunning PW, et al. Elife. 2018 Feb 1;7:e34477. doi: 10.7554/eLife.34477. Elife. 2018. PMID: 29388551 Free PMC article.
The differences between beta- and gamma-actin are deeper than those between the amino acid sequences of these two proteins....
The differences between beta- and gamma-actin are deeper than those between the amino acid sequences of these two proteins....
Mammalian Actins: Isoform-Specific Functions and Diseases.
Ampe C, Van Troys M. Ampe C, et al. Handb Exp Pharmacol. 2017;235:1-37. doi: 10.1007/164_2016_43. Handb Exp Pharmacol. 2017. PMID: 27757757 Review.
Actin is the central building block of the actin cytoskeleton, a highly regulated filamentous network enabling dynamic processes of cells and simultaneously providing structure. Mammals have six actin isoforms that are very conserved and thus share common fun …
Actin is the central building block of the actin cytoskeleton, a highly regulated filamentous network enabling dynamic process …
Nuclear roles for actin.
Wesolowska N, Lénárt P. Wesolowska N, et al. Chromosoma. 2015 Dec;124(4):481-9. doi: 10.1007/s00412-015-0519-8. Epub 2015 May 6. Chromosoma. 2015. PMID: 25944357 Review.
Actin's presence in the nucleus is a subject that has ignited a lot of controversy in the past. ...We take a rather conservative approach to build an argument that recent studies provide multiple independent lines of evidence substantiating actin's div …
Actin's presence in the nucleus is a subject that has ignited a lot of controversy in the past. ...We take a rather conservati …
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