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Page 1
Showing results for adenophostin
Search for adenoprosin instead (3 results)
Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors.
Su X, Dohle W, Mills SJ, Watt JM, Rossi AM, Taylor CW, Potter BVL. Su X, et al. ACS Omega. 2020 Oct 28;5(44):28793-28811. doi: 10.1021/acsomega.0c04145. eCollection 2020 Nov 10. ACS Omega. 2020. PMID: 33195933 Free PMC article.
d-myo-Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are Ca(2+) channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP(3), 1). The glyconucleotide adenophostin A (AdA, 2) is a potent agonist of IP(3)Rs. A recent synthesis of d-chiro-inositol …
d-myo-Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are Ca(2+) channels activated by the intracellular messenger inositol 1,4,5-trisphosp …
Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity.
Borissow CN, Black SJ, Paul M, Tovey SC, Dedos SG, Taylor CW, Potter BV. Borissow CN, et al. Org Biomol Chem. 2005 Jan 21;3(2):245-52. doi: 10.1039/b415229h. Epub 2004 Dec 13. Org Biomol Chem. 2005. PMID: 15632966
The synthesis of adenophostin A (2) and two analogues [etheno adenophostin (4) and 8-bromo adenophostin (5)] modified at the adenine moiety, is reported. ...The analogues were tested for their ability to mobilise Ca(2+) from DT40 cells expressing recombinant …
The synthesis of adenophostin A (2) and two analogues [etheno adenophostin (4) and 8-bromo adenophostin (5)] modified a …
Adenophostin A can stimulate Ca2+ influx without depleting the inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in the Xenopus oocyte.
DeLisle S, Marksberry EW, Bonnett C, Jenkins DJ, Potter BV, Takahashi M, Tanzawa K. DeLisle S, et al. J Biol Chem. 1997 Apr 11;272(15):9956-61. doi: 10.1074/jbc.272.15.9956. J Biol Chem. 1997. PMID: 9092535 Free article.
Adenophostin A possesses the highest known affinity for the inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) receptor (InsP3R). ...Heparin, which blocks binding to the InsP3R, prevented adenophostin-induced Ca2+ influx. These data indicate that adenophostin A can …
Adenophostin A possesses the highest known affinity for the inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) receptor (InsP3R). ...Heparin …
Adenophostin A induces spatially restricted calcium signaling in Xenopus laevis oocytes.
Bird GS, Takahashi M, Tanzawa K, Putney JW Jr. Bird GS, et al. J Biol Chem. 1999 Jul 16;274(29):20643-9. doi: 10.1074/jbc.274.29.20643. J Biol Chem. 1999. PMID: 10400696 Free article.
Injection of low concentrations of adenophostin A resulted in calcium signals that spread slowly (>1 h). ...When the adenophostin A-induced calcium signal was restricted to central regions, compartmentalized calcium oscillations were sometimes observed. ...
Injection of low concentrations of adenophostin A resulted in calcium signals that spread slowly (>1 h). ...When the adenophost …
Adenophostin, a potent agonist of the inositol 1,4,5-trisphosphate receptor, is useful for fertilization of mouse oocytes injected with round spermatids leading to normal offspring.
Sato Y, Miyazaki S, Shikano T, Mitsuhashi N, Takeuchi H, Mikoshiba K, Kuwabara Y. Sato Y, et al. Biol Reprod. 1998 Mar;58(3):867-73. doi: 10.1095/biolreprod58.3.867. Biol Reprod. 1998. PMID: 9510978
Ca2+ oscillations were blocked by an antibody against the type 1 InsP3r. About 95% of oocytes were activated by adenophostin (0.3-0.4 microM in the oocyte). Simultaneous injection of a round spermatid and adenophostin resulted in 55% fertilization success in associa …
Ca2+ oscillations were blocked by an antibody against the type 1 InsP3r. About 95% of oocytes were activated by adenophostin (0.3-0.4 …
Structural determinants of adenophostin A activity at inositol trisphosphate receptors.
Correa V, Riley AM, Shuto S, Horne G, Nerou EP, Marwood RD, Potter BV, Taylor CW. Correa V, et al. Mol Pharmacol. 2001 May;59(5):1206-15. doi: 10.1124/mol.59.5.1206. Mol Pharmacol. 2001. PMID: 11306705
Adenophostin A is the most potent known agonist of inositol 1,4,5-trisphosphate (InsP(3)) receptors. ...Xylo-adenophostin, where xylose replaces the glucose ring of adenophostin A, was only slightly less potent than adenophostin A, whereas manno-ade …
Adenophostin A is the most potent known agonist of inositol 1,4,5-trisphosphate (InsP(3)) receptors. ...Xylo-adenophostin, whe …
Molecular recognition of adenophostin, a very potent Ca2+ inducer, at the D-myo-inositol 1,4,5-trisphosphate receptor.
Hotoda H, Murayama K, Miyamoto S, Iwata Y, Takahashi M, Kawase Y, Tanzawa K, Kaneko M. Hotoda H, et al. Biochemistry. 1999 Jul 20;38(29):9234-41. doi: 10.1021/bi990114r. Biochemistry. 1999. PMID: 10413497
The recognition mode of adenophostin A at the D-myo-inositol 1,4, 5-trisphosphate [Ins(1,4,5)P(3)] receptor was investigated. ...GlcdR(2,3',4')P(3), an adenophostin analogue without adenine moiety, was found to be less potent than adenophostin A and almost eq …
The recognition mode of adenophostin A at the D-myo-inositol 1,4, 5-trisphosphate [Ins(1,4,5)P(3)] receptor was investigated. ...Glcd …
Adenophostin A and inositol 1,4,5-trisphosphate differentially activate Cl- currents in Xenopus oocytes because of disparate Ca2+ release kinetics.
Machaca K, Hartzell HC. Machaca K, et al. J Biol Chem. 1999 Feb 19;274(8):4824-31. doi: 10.1074/jbc.274.8.4824. J Biol Chem. 1999. PMID: 9988722 Free article.
Depletion of endoplasmic reticulum Ca2+ stores induces Ca2+ entry from the extracellular space by a process termed "store-operated Ca2+ entry" (SOCE). It has been suggested that the novel fungal metabolite adenophostin-A may be able to stimulate Ca2+ entry without stimulat …
Depletion of endoplasmic reticulum Ca2+ stores induces Ca2+ entry from the extracellular space by a process termed "store-operated Ca2+ entr …
Determinants of adenophostin A binding to inositol trisphosphate receptors.
Morris SA, Nerou EP, Riley AM, Potter BV, Taylor CW. Morris SA, et al. Biochem J. 2002 Oct 1;367(Pt 1):113-20. doi: 10.1042/BJ20020675. Biochem J. 2002. PMID: 12088506 Free PMC article.
It has been suggested that adenophostin A binds with high affinity only in the presence of ATP, but we found that adenophostin A similarly displaced [(3)H]IP(3) from type 1 IP(3) receptors whatever the ATP concentration. ...The 224-604S1(+) fragment bound IP(3) and …
It has been suggested that adenophostin A binds with high affinity only in the presence of ATP, but we found that adenophostin …
Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.
Marchant JS, Beecroft MD, Riley AM, Jenkins DJ, Marwood RD, Taylor CW, Potter BV. Marchant JS, et al. Biochemistry. 1997 Oct 21;36(42):12780-90. doi: 10.1021/bi971397v. Biochemistry. 1997. PMID: 9335535
The glyconucleotides adenophostin A and B are the most potent known agonists at type 1 inositol trisphosphate [Ins(1,4,5)P3] receptors, although their stuctures differ markedly from that of Ins(1,4,5)P3. ...Both Ins(1,4,5)P3 (Kd = 8.65 +/- 0.98 nM) and adenophostin …
The glyconucleotides adenophostin A and B are the most potent known agonists at type 1 inositol trisphosphate [Ins(1,4,5)P3] receptor …
133 results