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Showing results for vdipen
Your search for adipen retrieved no results
VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.
Singer II, Kawka DW, Bayne EK, Donatelli SA, Weidner JR, Williams HR, Ayala JM, Mumford RA, Lark MW, Glant TT, et al. Singer II, et al. J Clin Invest. 1995 May;95(5):2178-86. doi: 10.1172/JCI117907. J Clin Invest. 1995. PMID: 7537757 Free PMC article.
This aggrecan neoepitope was colocalized with high levels of glycosaminoglycans (GAGs) in pericellular matrices of AC chondrocytes but was not seen at the articular surface at this early time. Digestion of normal (VDIPEN negative) mouse paw cryosections with SLN also produ …
This aggrecan neoepitope was colocalized with high levels of glycosaminoglycans (GAGs) in pericellular matrices of AC chondrocytes but was n …
Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis.
van Meurs JB, van Lent PL, Singer II, Bayne EK, van de Loo FA, van den Berg WB. van Meurs JB, et al. Arthritis Rheum. 1998 Apr;41(4):647-56. doi: 10.1002/1529-0131(199804)41:4<647::AID-ART11>3.0.CO;2-T. Arthritis Rheum. 1998. PMID: 9550473
OBJECTIVE: To investigate the relationship between occurrence of the matrix metalloproteinase-generated neoepitope VDIPEN and proteoglycan (PG) loss in arthritis, and to examine the role of interleukin-1 (IL-1) in VDIPEN expression. ...However, IL-1Ra had only a min …
OBJECTIVE: To investigate the relationship between occurrence of the matrix metalloproteinase-generated neoepitope VDIPEN and proteog …
Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.
van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, van den Berg WB. van Meurs JB, et al. Arthritis Rheum. 1999 Jun;42(6):1128-39. doi: 10.1002/1529-0131(199906)42:6<1128::AID-ANR9>3.0.CO;2-2. Arthritis Rheum. 1999. PMID: 10366105 Free article.
When PG depletion progressed toward advanced cartilage damage, VDIPEN epitopes were induced. During ZIA, minimal induction of VDIPEN was observed, whereas in AIA, strong, but partly reversible, VDIPEN staining was evident, and in CIA, an extensive presence an …
When PG depletion progressed toward advanced cartilage damage, VDIPEN epitopes were induced. During ZIA, minimal induction of VDIP …
Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice.
Chambers MG, Cox L, Chong L, Suri N, Cover P, Bayliss MT, Mason RM. Chambers MG, et al. Arthritis Rheum. 2001 Jun;44(6):1455-65. doi: 10.1002/1529-0131(200106)44:6<1455::AID-ART241>3.0.CO;2-J. Arthritis Rheum. 2001. PMID: 11407708 Free article.
In early OA, VDIPEN immunostaining also localized to the pericellular matrix of chondrocytes at the site of the lesion. With increasing severity of OA lesions, VDIPEN immunostaining was also detected in the interterritorial matrix, close to the site of the lesion. . …
In early OA, VDIPEN immunostaining also localized to the pericellular matrix of chondrocytes at the site of the lesion. With increasi …
The role of NOX2-derived reactive oxygen species in collagenase-induced osteoarthritis.
van Dalen SCM, Kruisbergen NNL, Walgreen B, Helsen MMA, Slöetjes AW, Cremers NAJ, Koenders MI, van de Loo FAJ, Roth J, Vogl T, Blom AB, van der Kraan PM, van Lent PLEM, van den Bosch MHJ. van Dalen SCM, et al. Osteoarthritis Cartilage. 2018 Dec;26(12):1722-1732. doi: 10.1016/j.joca.2018.08.014. Epub 2018 Sep 5. Osteoarthritis Cartilage. 2018. PMID: 30195046 Free article.
Joint pathology was assessed using histology and immunohistochemistry for aggrecan neo-epitope VDIPEN. Levels of inflammatory proteins were measured with Luminex or ELISA. ...On day 7 of CiOA, cartilage damage and MMP activity, as measured by VDIPEN, were comparable …
Joint pathology was assessed using histology and immunohistochemistry for aggrecan neo-epitope VDIPEN. Levels of inflammatory protein …
Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis.
van Meurs JB, van Lent PL, van de Loo AA, Holthuysen AE, Bayne EK, Singer II, van den Berg WB. van Meurs JB, et al. Ann Rheum Dis. 1999 Jun;58(6):350-6. doi: 10.1136/ard.58.6.350. Ann Rheum Dis. 1999. PMID: 10340959 Free PMC article.
RESULTS: At the onset of AIA, a fast upregulation of mRNA for stromelysin and collagenase was noted. However, no VDIPEN epitopes were detected during this early phase of arthritis. ...Moreover, increased levels of latent MMPs were present as well, as APMA activation induce …
RESULTS: At the onset of AIA, a fast upregulation of mRNA for stromelysin and collagenase was noted. However, no VDIPEN epitopes were …
Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis.
van Lent PL, Grevers LC, Blom AB, Arntz OJ, van de Loo FA, van der Kraan P, Abdollahi-Roodsaz S, Srikrishna G, Freeze H, Sloetjes A, Nacken W, Vogl T, Roth J, van den Berg WB. van Lent PL, et al. Arthritis Rheum. 2008 Dec;58(12):3776-87. doi: 10.1002/art.24074. Arthritis Rheum. 2008. PMID: 19035520 Free article.
Breakdown of aggrecan on the pericellular surface of the chondrocytes was measured using VDIPEN and NITEGE antibodies and FACS, and breakdown in patellar cartilage was measured by immunolocalization. ...(VDIPEN levels were elevated 17%, 67%, and 108%, respectively, …
Breakdown of aggrecan on the pericellular surface of the chondrocytes was measured using VDIPEN and NITEGE antibodies and FACS, and b …
Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.
Nabbe KC, Blom AB, Holthuysen AE, Boross P, Roth J, Verbeek S, van Lent PL, van den Berg WB. Nabbe KC, et al. Arthritis Rheum. 2003 Jan;48(1):255-65. doi: 10.1002/art.10721. Arthritis Rheum. 2003. PMID: 12528127 Free article.
Initiation of erosive cartilage destruction, as reflected by MMP-mediated VDIPEN expression, was reduced in Fc gamma RIII(-/-) and Fc gamma RI(-/-) mice, directing the two different critical steps of cellular influx and subsequent activation. These aspects were enhanced in …
Initiation of erosive cartilage destruction, as reflected by MMP-mediated VDIPEN expression, was reduced in Fc gamma RIII(-/-) and Fc …
Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.
van Meurs J, van Lent P, Holthuysen A, Lambrou D, Bayne E, Singer I, van den Berg W. van Meurs J, et al. J Immunol. 1999 Nov 15;163(10):5633-9. J Immunol. 1999. PMID: 10553093
VDIPEN expression was studied in vitro by exposing the cartilage to IL-1 and subsequent activation of latent MMPs. ...SLN-1KO mice did not show expression of the VDIPEN neoepitope, although inflammation and proteoglycan depletion was comparable to wild-type mice. .. …
VDIPEN expression was studied in vitro by exposing the cartilage to IL-1 and subsequent activation of latent MMPs. ...SLN-1KO mice di …
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
van Meurs J, van Lent P, Stoop R, Holthuysen A, Singer I, Bayne E, Mudgett J, Poole R, Billinghurst C, van der Kraan P, Buma P, van den Berg W. van Meurs J, et al. Arthritis Rheum. 1999 Oct;42(10):2074-84. doi: 10.1002/1529-0131(199910)42:10<2074::AID-ANR7>3.0.CO;2-5. Arthritis Rheum. 1999. PMID: 10524678 Free article.
Stromelysin 1-deficient knockout (SLN1-KO) mice were used to study SLN-1 involvement. RESULTS: In AIA, the VDIPEN epitopes in aggrecan appeared after initial proteoglycan (PG) depletion. The collagenase-induced type II collagen neoepitopes colocalized with VDIPEN ep …
Stromelysin 1-deficient knockout (SLN1-KO) mice were used to study SLN-1 involvement. RESULTS: In AIA, the VDIPEN epitopes in aggreca …
52 results