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Metabolic activation of aegeline mediated by CYP2C19.
Tian M, Zhou S, Li W, Li J, Yang L, Peng Y, Zheng J. Tian M, et al. Xenobiotica. 2021 Nov;51(11):1217-1228. doi: 10.1080/00498254.2021.1913666. Epub 2021 Nov 7. Xenobiotica. 2021. PMID: 33892609
Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacological activities.As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. ...
Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multip …
Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing alpha-synuclein and Bax toxicity in yeast.
Derf A, Sharma A, Bharate SB, Chaudhuri B. Derf A, et al. Bioorg Med Chem Lett. 2019 Feb 1;29(3):454-460. doi: 10.1016/j.bmcl.2018.12.028. Epub 2018 Dec 13. Bioorg Med Chem Lett. 2019. PMID: 30579794
With the aim of finding a small molecule that would mimic ySec22p, a library of natural products consisting of 394-compounds was screened using yeast cells that express either human alpha-synuclein or human Bax. The antioxidant aegeline, an alkaloid-amide occurring in the …
With the aim of finding a small molecule that would mimic ySec22p, a library of natural products consisting of 394-compounds was screened us …
Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1.
Gautam S, Ishrat N, Singh R, Narender T, Srivastava AK. Gautam S, et al. Eur J Pharmacol. 2015 Sep 5;762:419-29. doi: 10.1016/j.ejphar.2015.05.021. Epub 2015 Jun 20. Eur J Pharmacol. 2015. PMID: 26102565
Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). ...Therefore, multiple targets of aegeline in the improvement of insulin sensitivity of the skeletal muscle cells may be suggested....
Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). ...Therefore, mul …
Aegeline attenuates TNBS-induced colitis by suppressing the NFkB-mediated NLRP3 inflammasome pathway in mice.
Shah B, Solanki N. Shah B, et al. Inflammopharmacology. 2024 May 20. doi: 10.1007/s10787-024-01493-0. Online ahead of print. Inflammopharmacology. 2024. PMID: 38767762
The study aimed to investigate the effectiveness of aegeline in alleviating 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis through the NFkB-mediated NLRP3 inflammasome pathway. ...Aegeline in high dose significantly downregulated the gene expression of N …
The study aimed to investigate the effectiveness of aegeline in alleviating 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced coliti …
Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice.
Manda VK, Haron MH, Mir TM, Avula B, Ashfaq MK, Haider S, Chittiboyina AG, Khan IA, Khan SI. Manda VK, et al. Planta Med. 2019 Apr;85(6):491-495. doi: 10.1055/a-0851-6879. Epub 2019 Feb 12. Planta Med. 2019. PMID: 30754052
Aegeline is claimed to be a biologically active constituent of Aegle marmelos. Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight loss products …
Aegeline is claimed to be a biologically active constituent of Aegle marmelos. Preclinical studies have reported possible therapeutic …
Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells.
Satish S, Srivastava A, Yadav P, Varshney S, Choudhary R, Balaramnavar VM, Narender T, Gaikwad AN. Satish S, et al. Eur J Med Chem. 2018 Jan 1;143:780-791. doi: 10.1016/j.ejmech.2017.11.041. Epub 2017 Nov 26. Eur J Med Chem. 2018. PMID: 29220798
Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, our group had reported natural product Aegeline (amino-alcohol) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipi …
Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, our gr …
Aegeline inspired synthesis of novel beta3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance.
Rajan S, Satish S, Shankar K, Pandeti S, Varshney S, Srivastava A, Kumar D, Gupta A, Gupta S, Choudhary R, Balaramnavar VM, Narender T, Gaikwad AN. Rajan S, et al. Metabolism. 2018 Aug;85:1-13. doi: 10.1016/j.metabol.2018.03.001. Epub 2018 Mar 8. Metabolism. 2018. PMID: 29524448
In our present study, we have evaluated the beta3-AR activity of novel N-acyl-1-amino-3-arylopropanol synthetic mimics of aegeline and its beneficial effect in insulin resistance. In this study, we have proposed the novel pharmacophore model using reported molecules for an …
In our present study, we have evaluated the beta3-AR activity of novel N-acyl-1-amino-3-arylopropanol synthetic mimics of aegeline an …
Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS.
Singh AP, Singh L, Singh P, Bhatti R. Singh AP, et al. ACS Omega. 2021 Jan 11;6(3):2034-2044. doi: 10.1021/acsomega.0c04739. eCollection 2021 Jan 26. ACS Omega. 2021. PMID: 33521442 Free PMC article.
In silico molecular docking studies of aegeline showed a good binding interaction at the active sites of MAO-A and iNOS. ...Immunofluorescence studies also showed that AMFE and aegeline abrogated the reserpine-induced increase in iNOS expression. ...
In silico molecular docking studies of aegeline showed a good binding interaction at the active sites of MAO-A and iNOS. ...Immunoflu …
Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells.
Nugroho AE, Riyanto S, Sukari MA, Maeyama K. Nugroho AE, et al. Pak J Pharm Sci. 2011 Jul;24(3):359-67. Pak J Pharm Sci. 2011. PMID: 21715270
Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca(2+) stimulants such as thapsigargin and ionomycin. Aegeline is suggested to influence the intracellular Ca(2+) pool only since could not inhibit the (45)Ca(2+) influx into RBL-2H3 cells. ...
Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca(2+) stimulants such as thapsigargin and ionomycin. Aege …
33 results