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Year Number of Results
1992 1
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2002 1
2003 1
2006 1
2007 5
2008 7
2009 4
2010 3
2011 4
2012 2
2013 4
2014 9
2015 6
2016 2
2017 1
2018 2
2019 7
2020 6
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2023 19
2024 6

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107 results

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Page 1
Alcohol and its associated liver carcinogenesis.
Jacob R, Prince DS, Kench C, Liu K. Jacob R, et al. J Gastroenterol Hepatol. 2023 Aug;38(8):1211-1217. doi: 10.1111/jgh.16248. Epub 2023 Jun 1. J Gastroenterol Hepatol. 2023. PMID: 37263779 Review.
The prevalence of alcohol-associated hepatocellular carcinoma (aHCC) varies worldwide but is highest in Eastern Europe. Alcohol is the second fastest-growing cause of age-standardized liver cancer mortality with tumors more often diagnosed outside surveillance proto …
The prevalence of alcohol-associated hepatocellular carcinoma (aHCC) varies worldwide but is highest in Eastern Europe. Alcohol is th …
Effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation.
Kim H, Kim JH, Im JA. Kim H, et al. J Nutr Sci Vitaminol (Tokyo). 2014;60(5):348-56. doi: 10.3177/jnsv.60.348. J Nutr Sci Vitaminol (Tokyo). 2014. PMID: 25744424 Free article. Clinical Trial.
To investigate the effects of Active Hexose Correlated Compound (AHCC) supplementation and the mechanism action of AHCC in patients with alcohol-induced mildly elevated liver enzyme levels, participants were randomly allocated to the placebo, 1 g AHCC, …
To investigate the effects of Active Hexose Correlated Compound (AHCC) supplementation and the mechanism action of AHCC in pat …
Systemic therapy of liver cancer.
Demir T, Lee SS, Kaseb AO. Demir T, et al. Adv Cancer Res. 2021;149:257-294. doi: 10.1016/bs.acr.2020.12.001. Epub 2021 Jan 29. Adv Cancer Res. 2021. PMID: 33579425 Review.
More than 80% of patients are diagnosed at an advanced stage, and most patients with HCC also have liver cirrhosis that complicates cancer management. No targeted treatment options currently exist outside genomics-based clinical trials. ...In this chapter, we summarize cur …
More than 80% of patients are diagnosed at an advanced stage, and most patients with HCC also have liver cirrhosis that complicates c …
Alcohol-associated liver cancer.
Fu Y, Maccioni L, Wang XW, Greten TF, Gao B. Fu Y, et al. Hepatology. 2024 Apr 12. doi: 10.1097/HEP.0000000000000890. Online ahead of print. Hepatology. 2024. PMID: 38607725
Heavy alcohol intake induces a wide spectrum of liver diseases ranging from steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). ...In the current review, we discuss the pathogenesis, heterogeneity, preclinical approaches, epigenetic and genetic profi …
Heavy alcohol intake induces a wide spectrum of liver diseases ranging from steatosis, steatohepatitis, cirrhosis, and hepatocellular …
Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma.
Haber PK, Castet F, Torres-Martin M, Andreu-Oller C, Puigvehí M, Miho M, Radu P, Dufour JF, Verslype C, Zimpel C, Marquardt JU, Galle PR, Vogel A, Bathon M, Meyer T, Labgaa I, Digklia A, Roberts LR, Mohamed Ali MA, Mínguez B, Citterio D, Mazzaferro V, Finkelmeier F, Trojan J, Özdirik B, Müller T, Schmelzle M, Bejjani A, Sung MW, Schwartz ME, Finn RS, Thung S, Villanueva A, Sia D, Llovet JM. Haber PK, et al. Gastroenterology. 2023 Jan;164(1):72-88.e18. doi: 10.1053/j.gastro.2022.09.005. Epub 2022 Sep 12. Gastroenterology. 2023. PMID: 36108710 Free article.
BACKGROUND & AIMS: Single-agent anti-PD1 checkpoint inhibitors convey outstanding clinical benefits in a small fraction (20%) of patients with advanced hepatocellular carcinoma (aHCC) but the molecular mechanisms determining response are unknown. To fill this gap, we h …
BACKGROUND & AIMS: Single-agent anti-PD1 checkpoint inhibitors convey outstanding clinical benefits in a small fraction (20%) of patient …
First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Systematic Review and Patient-Level Network Meta-Analysis.
Fong KY, Zhao JJ, Sultana R, Lee JJX, Lee SY, Chan SL, Yau T, Tai DWM, Sundar R, Too CW. Fong KY, et al. Liver Cancer. 2022 Aug 23;12(1):7-18. doi: 10.1159/000526639. eCollection 2023 Feb. Liver Cancer. 2022. PMID: 36872922 Free PMC article.
INTRODUCTION: Sorafenib was historically the standard of care for advanced hepatocellular carcinoma (aHCC) until it was superseded by the combination of atezolizumab and bevacizumab. ...CONCLUSION: This NMA supports Anti-PD-(L)1/VEGF Ab as the first-line therapy for aHC …
INTRODUCTION: Sorafenib was historically the standard of care for advanced hepatocellular carcinoma (aHCC) until it was superseded by …
CheckMate 040 cohort 5: A phase I/II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis.
Kudo M, Matilla A, Santoro A, Melero I, Gracián AC, Acosta-Rivera M, Choo SP, El-Khoueiry AB, Kuromatsu R, El-Rayes B, Numata K, Itoh Y, Di Costanzo F, Crysler O, Reig M, Shen Y, Neely J, Tschaika M, Wisniewski T, Sangro B. Kudo M, et al. J Hepatol. 2021 Sep;75(3):600-609. doi: 10.1016/j.jhep.2021.04.047. Epub 2021 May 26. J Hepatol. 2021. PMID: 34051329 Free article.
BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (aHCC) and Child-Pugh B liver function are often excluded from clinical trials. ...The safety of nivolumab was comparable to that in patients with Child-Pugh A aHCC. CONCLUSIONS: Nivolumab …
BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (aHCC) and Child-Pugh B liver function are often exclud …
Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment.
Cowawintaweewat S, Manoromana S, Sriplung H, Khuhaprema T, Tongtawe P, Tapchaisri P, Chaicumpa W. Cowawintaweewat S, et al. Asian Pac J Allergy Immunol. 2006 Mar;24(1):33-45. Asian Pac J Allergy Immunol. 2006. PMID: 16913187 Free article. Clinical Trial.
We investigated whether AHCC could prolong survival and improve the prognosis of patients with advanced liver cancer. ...In addition, the levels of total IL-12 and neopterin were slightly increased in AHCC treated-patients. This study suggests that AHCC …
We investigated whether AHCC could prolong survival and improve the prognosis of patients with advanced liver cancer. ...In ad …
Predictive and Prognostic Potential of Liver Function Assessment in Patients with Advanced Hepatocellular Carcinoma: A Systematic Literature Review.
Vogel A, Kelley RK, Johnson P, Merle P, Yau T, Kudo M, Meyer T, Rimassa L. Vogel A, et al. Liver Cancer. 2023 Jan 17;12(4):372-391. doi: 10.1159/000529173. eCollection 2023 Sep. Liver Cancer. 2023. PMID: 37817754 Free PMC article.
Analyses of cross-trial trends of within-exposure arm analyses (active and control) reported a positive relationship between baseline liver function and overall survival and progression-free survival, supporting liver function as a prognostic marker in aHCC. …
Analyses of cross-trial trends of within-exposure arm analyses (active and control) reported a positive relationship between baseline liv …
Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC).
Fujii H, Nishioka N, Simon RR, Kaur R, Lynch B, Roberts A. Fujii H, et al. Regul Toxicol Pharmacol. 2011 Mar;59(2):237-50. doi: 10.1016/j.yrtph.2010.10.006. Epub 2010 Oct 14. Regul Toxicol Pharmacol. 2011. PMID: 20951179
AHCC is used in Japan as a dietary supplement to boost immune function and it also is purported to improve the symptoms of cancer and liver disease patients. A series of toxicological studies were conducted on a freeze dried preparation of AHCC (AHCC-F …
AHCC is used in Japan as a dietary supplement to boost immune function and it also is purported to improve the symptoms of cancer and …
107 results