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Showing results for ak dox
Your search for ak-dex retrieved no results
Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy.
Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela Ripoll C, Billia F, Diwan A, Javaheri A, Kirshenbaum LA. Dhingra R, et al. Circulation. 2022 Sep 20;146(12):934-954. doi: 10.1161/CIRCULATIONAHA.121.058411. Epub 2022 Aug 19. Circulation. 2022. PMID: 35983756 Free PMC article.
Last, cardiomyocyte-restricted expression of TRAF2 (cardiac troponin T-adeno-associated virus 9-TRAF2) in vivo protected against mitochondrial defects and cardiac dysfunction induced by DOX. CONCLUSIONS: Our findings reveal a novel signaling axis that functionally connects …
Last, cardiomyocyte-restricted expression of TRAF2 (cardiac troponin T-adeno-associated virus 9-TRAF2) in vivo protected against mitochondri …
Interaction of doxorubicin delivered by superparamagnetic iron oxide nanoparticles with DNA.
Dukhopelnykov EV, Blyzniuk YN, Skuratovska AA, Bereznyak EG, Gladkovskaya NA. Dukhopelnykov EV, et al. Colloids Surf B Biointerfaces. 2022 Nov;219:112815. doi: 10.1016/j.colsurfb.2022.112815. Epub 2022 Aug 29. Colloids Surf B Biointerfaces. 2022. PMID: 36108366 Free article.
The DNA addition to the DOX-SPION system induces DOX release from the SPION surface and the formation of DOX-DNA complexes. ...Thus, SPIONs are perspective nanocarriers for DOX delivery....
The DNA addition to the DOX-SPION system induces DOX release from the SPION surface and the formation of DOX-DNA comple …
Sanazole directed targeting of silver nanoparticle drug complex to tumor mass: a preclinical investigation in murine model.
Nair GG, Nair CK. Nair GG, et al. J Cancer Res Ther. 2014 Oct-Dec;10(4):979-84. doi: 10.4103/0973-1482.148705. J Cancer Res Ther. 2014. PMID: 25579540 Free article.
RESULTS: Under in vitro conditions, SN, AK, DOX, SN-AK, SN-DOX, AK-DOX, and SN-AK-DOX induced cytotoxicity and apoptosis in DLA cells to varying extents. ...Similarly, administration of SN, AK, DOX, SN-AK …
RESULTS: Under in vitro conditions, SN, AK, DOX, SN-AK, SN-DOX, AK-DOX, and SN-AK-DOX …
The combined effect of creatine and resistance training on doxorubicin-induced muscle dysfunction.
Bredahl EC, Busekrus RB, Hydock DS. Bredahl EC, et al. Nutr Cancer. 2020;72(6):939-947. doi: 10.1080/01635581.2019.1670852. Epub 2019 Oct 7. Nutr Cancer. 2020. PMID: 31588781
Background: Doxorubicin (DOX) is associated with profound skeletal muscle dysfunction. Resistance training (RT) and creatine (Cr) monohydrate have been independently shown to protect against DOX-induced muscle dysfunction. ...RT delayed DOX-induced fatigue by …
Background: Doxorubicin (DOX) is associated with profound skeletal muscle dysfunction. Resistance training (RT) and creatine (Cr) mon …
A/D-rings-seco limonoids from the fruits of Aglaia edulis and their bioactivities.
Sun Y, Cui L, Sun Y, Li Q, Li Y, Wang Z, Xu W, Kong L, Luo J. Sun Y, et al. Phytochemistry. 2022 Mar;195:113049. doi: 10.1016/j.phytochem.2021.113049. Epub 2021 Dec 10. Phytochemistry. 2022. PMID: 34902704
In addition, agleduline I and 11alpha-acetoxygedunin reversed the multidrug resistance with IC(50) values of 5.05 and 1.49 muM (RI: 4.64 and 15.77) in the MCF-7/Dox cells....
In addition, agleduline I and 11alpha-acetoxygedunin reversed the multidrug resistance with IC(50) values of 5.05 and 1.49 muM (RI: 4.64 and …
Injectable Shear-Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations.
Zehtabi F, Gangrade A, Tseng K, Haghniaz R, Abasgholizadeh R, Montazerian H, Khorsandi D, Bahari J, Ahari A, Mohaghegh N, Kouchehbaghi NH, Mandal K, Mecwan M, Rashad A, de Barros NR, Byun Y, Ermis M, Kim HJ, Khademhosseini A. Zehtabi F, et al. Adv Funct Mater. 2023 Dec 15;33(51):2305880. doi: 10.1002/adfm.202305880. Epub 2023 Sep 8. Adv Funct Mater. 2023. PMID: 38558868
The results showed that STBs containing 4.5% w/w silicate nanoplatelet and 0.3% w/v of DOX were injectable and had a 2-fold increase in storage modulus compared to those without DOX. STB-DOX hydrogels also reduced clotting time by 33% compared to untreated bl …
The results showed that STBs containing 4.5% w/w silicate nanoplatelet and 0.3% w/v of DOX were injectable and had a 2-fold increase …
Identification of Human UMP/CMP Kinase 1 as Doxorubicin Binding Target Using Protein Microarray.
Chen S, Wang X, Ye X, Ma D, Chen C, Cai J, Fu Y, Cheng X, Chen Y, Gong X, Jin J. Chen S, et al. SLAS Discov. 2017 Sep;22(8):1007-1015. doi: 10.1177/2472555217707704. Epub 2017 May 1. SLAS Discov. 2017. PMID: 28459633 Free article.
Competitive and binding experiments further verified the binding of DOX to UMP/CMP kinase 1 (CMPK1), and microscale thermophoresis showed that DOX binds to CMPK1 with a K(d) of 1216 nM. ...A significant activation was observed at the concentration of 30 M DOX …
Competitive and binding experiments further verified the binding of DOX to UMP/CMP kinase 1 (CMPK1), and microscale thermophoresis sh …
d-chiro-Inositol Derivatives with Multidrug Resistance Reversal Activities from the Fruits of Chisocheton siamensis.
Sun Y, Wang Z, Hua W, Cui L, Kong L, Luo J. Sun Y, et al. J Nat Prod. 2023 Apr 28;86(4):860-868. doi: 10.1021/acs.jnatprod.2c01033. Epub 2023 Apr 5. J Nat Prod. 2023. PMID: 37020426
Bioactivity evaluation indicated that chisosiamols A, B, and J can reverse multidrug resistance in MCF-7/DOX cells in the IC(50) range of 3.4-6.5 muM (RF: 3.6-7.0)....
Bioactivity evaluation indicated that chisosiamols A, B, and J can reverse multidrug resistance in MCF-7/DOX cells in the IC(50) rang …
Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice.
Fitting S, Stevens DL, Khan FA, Scoggins KL, Enga RM, Beardsley PM, Knapp PE, Dewey WL, Hauser KF. Fitting S, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):96-105. doi: 10.1124/jpet.115.226407. Epub 2015 Nov 5. J Pharmacol Exp Ther. 2016. PMID: 26542403 Free PMC article.
Antinociceptive tolerance and locomotor activity tolerance were assessed using tail-flick and locomotor activity assays, respectively, and physical dependence was measured with the platform-jumping assay and recording of other withdrawal signs. We found that Tat(+) mice treated w …
Antinociceptive tolerance and locomotor activity tolerance were assessed using tail-flick and locomotor activity assays, respectively, and p …
Early detection of myocardial changes with and without dexrazoxane using serial magnetic resonance imaging in a pre-clinical mouse model.
Noel CV, Rainusso N, Robertson M, Romero J, Masand P, Coarfa C, Pautler R. Noel CV, et al. Cardiooncology. 2021 Jun 16;7(1):23. doi: 10.1186/s40959-021-00109-8. Cardiooncology. 2021. PMID: 34134789 Free PMC article.
RESULTS: Myocardial edema assessed by T2 time was the earliest parameter demonstrating evidence of myocardial injury, most notable in the DOX group at week 4 and 8 compared with DOX/DEX group. Similarly, global longitudinal strain was abnormal in both the DOX …
RESULTS: Myocardial edema assessed by T2 time was the earliest parameter demonstrating evidence of myocardial injury, most notable in the …
34 results