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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 4
1985 2
1986 1
1989 2
1990 2
1993 1
1994 4
1995 4
1996 4
1997 3
1998 5
1999 5
2000 6
2001 4
2002 4
2003 5
2004 4
2005 3
2006 7
2007 9
2008 8
2009 13
2010 10
2011 14
2012 12
2013 11
2014 9
2015 9
2016 11
2017 20
2018 14
2019 14
2020 18
2021 16
2022 18
2023 31
2024 15

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295 results

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Page 1
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium. Liu MC, et al. Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016/j.annonc.2020.02.011. Epub 2020 Mar 30. Ann Oncol. 2020. PMID: 33506766 Free PMC article.
In all cancer types sensitivity was 18% (CI: 13% to 25%) in stage I, 43% (CI: 35% to 51%) in stage II, 81% (CI: 73% to 87%) in stage III, and 93% (CI: 87% to 96%) in stage IV. TOO was predicted in 96% of samples with cancer-like signal; of those, the TOO localization was a …
In all cancer types sensitivity was 18% (CI: 13% to 25%) in stage I, 43% (CI: 35% to 51%) in stage II, 81% (CI: 73% to 87%) in stage III, an …
Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer.
Hunter FW, Barker HR, Lipert B, Rothé F, Gebhart G, Piccart-Gebhart MJ, Sotiriou C, Jamieson SMF. Hunter FW, et al. Br J Cancer. 2020 Mar;122(5):603-612. doi: 10.1038/s41416-019-0635-y. Epub 2019 Dec 16. Br J Cancer. 2020. PMID: 31839676 Free PMC article. Review.
T-DM1 mediates its activity in a number of ways, encompassing HER2 signalling blockade, Fc-mediated immune response and payload-mediated microtubule poisoning. ...In our overview of the substantial literature on T-DM1 activity and resistance, we conclude that the T-DM1 res …
T-DM1 mediates its activity in a number of ways, encompassing HER2 signalling blockade, Fc-mediated immune response and payload-media …
A framework for individualized splice-switching oligonucleotide therapy.
Kim J, Woo S, de Gusmao CM, Zhao B, Chin DH, DiDonato RL, Nguyen MA, Nakayama T, Hu CA, Soucy A, Kuniholm A, Thornton JK, Riccardi O, Friedman DA, El Achkar CM, Dash Z, Cornelissen L, Donado C, Faour KNW, Bush LW, Suslovitch V, Lentucci C, Park PJ, Lee EA, Patterson A, Philippakis AA, Margus B, Berde CB, Yu TW. Kim J, et al. Nature. 2023 Jul;619(7971):828-836. doi: 10.1038/s41586-023-06277-0. Epub 2023 Jul 12. Nature. 2023. PMID: 37438524 Free PMC article.
We developed ASOs that successfully rescued mis-splicing and ATM cellular signalling in patient fibroblasts for two recurrent variants. In a pilot clinical study, one of these ASOs was used to treat a child who had been diagnosed with ataxia-telangiectasia soon after birth …
We developed ASOs that successfully rescued mis-splicing and ATM cellular signalling in patient fibroblasts for two recurrent variant …
How Mechanical Forces Shape Plant Organs.
Trinh DC, Alonso-Serra J, Asaoka M, Colin L, Cortes M, Malivert A, Takatani S, Zhao F, Traas J, Trehin C, Hamant O. Trinh DC, et al. Curr Biol. 2021 Feb 8;31(3):R143-R159. doi: 10.1016/j.cub.2020.12.001. Curr Biol. 2021. PMID: 33561417 Free article. Review.
While much has been learned about genetic regulation of organogenesis, the integration of mechanics in the process is also gaining attention. Here, we consider the role of forces as instructive signals in organ morphogenesis. Turgor pressure is the primary cause of mechani …
While much has been learned about genetic regulation of organogenesis, the integration of mechanics in the process is also gaining attention …
The now and then of gut-brain signaling.
Kaelberer MM, Bohórquez DV. Kaelberer MM, et al. Brain Res. 2018 Aug 15;1693(Pt B):192-196. doi: 10.1016/j.brainres.2018.03.027. Epub 2018 Mar 23. Brain Res. 2018. PMID: 29580839 Free PMC article. Review.
Indeed, since first described as "clear cells" by Rudfolf Heidenhain (1868), research efforts increasingly focused on their hormone neuropeptides leading to the alphabetical classification of one cell-one hormone (e.g. I-cell synthesizes only cholecystokinin). ...This brie …
Indeed, since first described as "clear cells" by Rudfolf Heidenhain (1868), research efforts increasingly focused on their hormone neuropep …
"Perception of the speech code" revisited: Speech is alphabetic after all.
Fowler CA, Shankweiler D, Studdert-Kennedy M. Fowler CA, et al. Psychol Rev. 2016 Mar;123(2):125-50. doi: 10.1037/rev0000013. Epub 2015 Aug 24. Psychol Rev. 2016. PMID: 26301536 Review.
In the perspective of PSC, segments both exist (in language as known) and do not exist (in articulation or the acoustic speech signal). Findings interpreted as showing that speech is not a sound alphabet, but, rather, phonemes are encoded in the signal, coupl …
In the perspective of PSC, segments both exist (in language as known) and do not exist (in articulation or the acoustic speech signal …
An introduction to the sugar code.
Gabius HJ, Roth J. Gabius HJ, et al. Histochem Cell Biol. 2017 Feb;147(2):111-117. doi: 10.1007/s00418-016-1521-9. Epub 2016 Dec 14. Histochem Cell Biol. 2017. PMID: 27975142
The extent of compositional and structural variability of their oligomers (glycans) is unsurpassed in Nature due to the unique property of independently combining the following parameters with sequence: anomeric status, linkage positions, ring size, addition of branches and site- …
The extent of compositional and structural variability of their oligomers (glycans) is unsurpassed in Nature due to the unique property of i …
"Alphabet" Selenoproteins: Their Characteristics and Physiological Roles.
Dogaru CB, Muscurel C, Duță C, Stoian I. Dogaru CB, et al. Int J Mol Sci. 2023 Nov 6;24(21):15992. doi: 10.3390/ijms242115992. Int J Mol Sci. 2023. PMID: 37958974 Free PMC article. Review.
Selenoproteins mainly have oxidoreductase functions but are also involved in many different molecular signaling pathways, physiological roles, and complex pathogenic processes (including, for example, teratogenesis, neurodegenerative, immuno-inflammatory, and obesity devel …
Selenoproteins mainly have oxidoreductase functions but are also involved in many different molecular signaling pathways, physiologic …
Sigmoni: classification of nanopore signal with a compressed pangenome index.
Shivakumar VS, Ahmed OY, Kovaka S, Zakeri M, Langmead B. Shivakumar VS, et al. bioRxiv [Preprint]. 2023 Aug 30:2023.08.15.553308. doi: 10.1101/2023.08.15.553308. bioRxiv. 2023. PMID: 37645873 Free PMC article. Preprint.
But past methods for signal-based classification do not scale efficiently to large, repetitive references like pangenomes, limiting their utility to partial references or individual genomes. We introduce Sigmoni: a rapid, multiclass classification method based on the r-ind …
But past methods for signal-based classification do not scale efficiently to large, repetitive references like pangenomes, limiting t …
NLR receptors in plant immunity: making sense of the alphabet soup.
Contreras MP, Lüdke D, Pai H, Toghani A, Kamoun S. Contreras MP, et al. EMBO Rep. 2023 Oct 9;24(10):e57495. doi: 10.15252/embr.202357495. Epub 2023 Aug 21. EMBO Rep. 2023. PMID: 37602936 Free PMC article. Review.
Some plant NLRs act as multifunctional singleton receptors which combine pathogen detection and immune signaling. However, NLRs can also function in higher order pairs and networks of functionally specialized interconnected receptors. ...
Some plant NLRs act as multifunctional singleton receptors which combine pathogen detection and immune signaling. However, NLRs can a …
295 results