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1976 1
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Page 1
Ambazone as a membrane active antitumor drug.
Löber G, Hoffmann H. Löber G, et al. Biophys Chem. 1990 Apr;35(2-3):287-300. doi: 10.1016/0301-4622(90)80016-z. Biophys Chem. 1990. PMID: 2204445 Review.
Ambazone (1,4-benzoquinone guanylhydrazone thiosemicarbazone) was found to be active against various transplantable tumors in mice as well as rats. ...Ambazone induces an overall increase in the cellular cAMP content of leukemia ce …
Ambazone (1,4-benzoquinone guanylhydrazone thiosemicarbazone) was found to be active against vario …
Crystal structure and physicochemical characterization of ambazone monohydrate, anhydrous, and acetate salt solvate.
Muresan-Pop M, Braga D, Pop MM, Borodi G, Kacso I, Maini L. Muresan-Pop M, et al. J Pharm Sci. 2014 Nov;103(11):3594-3601. doi: 10.1002/jps.24151. Epub 2014 Sep 3. J Pharm Sci. 2014. PMID: 25187325
Ambazone monohydrate is characterized by an infinite three-dimensional network involving the water molecules, whereas anhydrous ambazone forms a two-dimensional network via hydrogen bonds. ...Additionally, a novel ambazone acetate salt solvate form was obtain …
Ambazone monohydrate is characterized by an infinite three-dimensional network involving the water molecules, whereas anhydrous am …
Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors.
Choi J, Jee JG. Choi J, et al. Int J Mol Sci. 2015 Dec 2;16(12):28534-48. doi: 10.3390/ijms161226114. Int J Mol Sci. 2015. PMID: 26633377 Free PMC article.
Ambazone decreased melanin content without causing cellular toxicity at 20 muM in B16F10 cells. The activity of ambazone was stronger than that of kojic acid both in enzyme and melanin content assays. ...
Ambazone decreased melanin content without causing cellular toxicity at 20 muM in B16F10 cells. The activity of ambazone was s …
Pharmacokinetics of 14C-ambazone in rats.
Kühnel HJ, Amlacher R, Kramarczyk K, Schulze W. Kühnel HJ, et al. Pharmazie. 1988 Mar;43(3):197-9. Pharmazie. 1988. PMID: 3380864
In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied. The results demonstrate that the compound is incompletely absorbed from the gastrointestinal tract, penetrates rapidly and to a high degree into various tissues and is preferentia …
In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied. The results demonstrate that the compou …
Age-dependent antileukemic action and suppression of immune response by 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) in mice.
Baumgart J, Wisniewski HG, Amlacher R, Zhukovskaya NV, Rentz E. Baumgart J, et al. Neoplasma. 1989;36(4):393-400. Neoplasma. 1989. PMID: 2770926
The antineoplastic activity of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) against murine leukemia P388 was found to be markedly reduced in 12- and 18-month-old mice as compared to young animals. ...Therefore immunosenes …
The antineoplastic activity of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) again …
[Quantitative determination of ambazone].
Kuhnke G, Göckeritz D, Pohlaudek-Fabini R. Kuhnke G, et al. Pharmazie. 1976 Nov;31(11):820-1. Pharmazie. 1976. PMID: 1023255 German. No abstract available.
[The effect of ambazone and ambazone derivatives on immunologic processes in human lymphocytes].
Janke B. Janke B. Pharmazie. 1990 Feb;45(2):126-7. Pharmazie. 1990. PMID: 2339169 German.
The influence of 1,4-benzoquinone-guanylhydrazone-thio-semicarbazone (1; ambazone), toluquinone-guanylhydrazone-thiosemicarbazone (2; ambazone 82/80) and p-(thio-semicarbacido)-diaminomethylenehydrazino benzene (3; dihydroambazone) on phytomitogen induced stimulatio …
The influence of 1,4-benzoquinone-guanylhydrazone-thio-semicarbazone (1; ambazone), toluquinone-guanylhydrazone-thiosemicarbazone (2; …
[Antineoplastic activity and toxicity of dihydroambazone in comparison with ambazone (1,4-benzoquinone-guanylhydrazone-thiosemicarbazone)].
Gutsche W, Härtl A, Baumgart J, Schulze W. Gutsche W, et al. Pharmazie. 1990 Jan;45(1):55-7. Pharmazie. 1990. PMID: 2333315 German.
The results were compared with that of ambazone. 1 was as active as ambazone upon the per os d 1-4 schedule only. ...The expectation of a favourable i.v. applicable derivative from the otherwise in water nearly insoluble ambazone could not be realized....
The results were compared with that of ambazone. 1 was as active as ambazone upon the per os d 1-4 schedule only. ...The expec …
Carcinogenesis and aging. VIII. Effect of host age on tumour growth, metastatic potential, and chemotherapeutic sensitivity to 1.4-benzoquinone-guanylhydrazonethiosemicarbazone (ambazone) and 5-fluorouracil in mice and rats.
Baumgart J, Zhukovskaya NV, Anisimov VN. Baumgart J, et al. Exp Pathol. 1988;33(4):239-48. Exp Pathol. 1988. PMID: 3229459
Survival of DBA/2 mice inoculated intraperitoneally (ip) with P388 cells was not influenced by the age of the host. The antineoplastic activity of ambazone and, to a less extent, of 5-fluorouracil against P388 was drastically lower in 12 months old mice than in 3 months ol …
Survival of DBA/2 mice inoculated intraperitoneally (ip) with P388 cells was not influenced by the age of the host. The antineoplastic activ …
Distribution of 14C-ambazone in normal and leukemia P 388-bearing mice.
Kühnel HJ, Amlacher R, Baumgart J, Schulze W. Kühnel HJ, et al. Arch Geschwulstforsch. 1988;58(4):217-22. Arch Geschwulstforsch. 1988. PMID: 3421808
The aim of the present study was to evaluate the influence of different stages and routes of inoculation of leukemia P 388 in B6D2F1-hybrid mice on the tissue distribution of ambazone, a new potential antineoplastic drug. It could be emphasized that the drug levels in live …
The aim of the present study was to evaluate the influence of different stages and routes of inoculation of leukemia P 388 in B6D2F1-hybrid …
26 results