Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment.
Bui TO, Angeli E, El Bouchtaoui M, Gapihan G, Dao VT, Paris J, Leboeuf C, Soussan M, Villarese P, Ziol M, Van Glabeke E, Le TH, Feugeas JP, Janin A, Bousquet G.
Bui TO, et al.
Exp Hematol Oncol. 2023 May 15;12(1):46. doi: 10.1186/s40164-023-00408-z.
Exp Hematol Oncol. 2023.
PMID: 37189165
Free PMC article.
RESULTS: We showed that pL1575P NOTCH1 mutation was an activating mutation, leading to the expression of NOTCH1-intracellular domain-active fragments in both cancer cells and tumor endothelial cells, suggesting a trans-differentiation of cancer cells into tumor micro-vesse …
RESULTS: We showed that pL1575P NOTCH1 mutation was an activating mutation, leading to the expression of NOTCH1-intracellular domain-active …