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Acetaminophen (APAP) hepatotoxicity-Isn't it time for APAP to go away?
Lee WM. Lee WM. J Hepatol. 2017 Dec;67(6):1324-1331. doi: 10.1016/j.jhep.2017.07.005. Epub 2017 Jul 20. J Hepatol. 2017. PMID: 28734939 Free PMC article. Review.
Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. ...As an over-the-counter and prescription product (with opioids), APAP toxicity dwarfs all other prescription drugs as a cause of acute liver failure in …
Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. ...As an over-the-co …
Evaluation and treatment of acetaminophen toxicity.
Fisher ES, Curry SC. Fisher ES, et al. Adv Pharmacol. 2019;85:263-272. doi: 10.1016/bs.apha.2018.12.004. Epub 2019 Jan 22. Adv Pharmacol. 2019. PMID: 31307590 Review.
A review of the typical clinical course, diagnosis and treatment of acetaminophen toxicity is provided. For an acute overdose, most adults must ingest about 12g or more acetaminophen (APAP) before risk of serious hepatotoxicity is of concern. A nomogram of se …
A review of the typical clinical course, diagnosis and treatment of acetaminophen toxicity is provided. For an acute overdose, most a …
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.
Ghanem CI, Pérez MJ, Manautou JE, Mottino AD. Ghanem CI, et al. Pharmacol Res. 2016 Jul;109:119-31. doi: 10.1016/j.phrs.2016.02.020. Epub 2016 Feb 26. Pharmacol Res. 2016. PMID: 26921661 Free PMC article. Review.
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. ...However, in the last decade the pharmacological mechanism of APAP as a cannabinoid system modulator has been documented and some articles have reported "in situ" toxicity by APAP i …
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. ...However, in the last decade the pharmacological mechan …
The spatiotemporal program of zonal liver regeneration following acute injury.
Ben-Moshe S, Veg T, Manco R, Dan S, Papinutti D, Lifshitz A, Kolodziejczyk AA, Bahar Halpern K, Elinav E, Itzkovitz S. Ben-Moshe S, et al. Cell Stem Cell. 2022 Jun 2;29(6):973-989.e10. doi: 10.1016/j.stem.2022.04.008. Cell Stem Cell. 2022. PMID: 35659879 Free article.
Here, we use spatially resolved single-cell RNA sequencing (scRNA-seq) to study the dynamics of mouse liver regeneration after acute acetaminophen (APAP) intoxication. We find that hepatocytes proliferate throughout the liver lobule, creating the mitotic pressure re …
Here, we use spatially resolved single-cell RNA sequencing (scRNA-seq) to study the dynamics of mouse liver regeneration after acute acet …
APAP-Induced IkappaBbeta/NFkappaB Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation.
Sherlock LG, Balasubramaniyan D, Zheng L, Grayck M, McCarthy WC, De Dios RC, Zarate MA, Orlicky DJ, De Dios R, Wright CJ. Sherlock LG, et al. Toxicol Sci. 2022 Jan 24;185(2):158-169. doi: 10.1093/toxsci/kfab131. Toxicol Sci. 2022. PMID: 34726736 Free PMC article.
Acetaminophen (APAP) overdose results in high morbidity and mortality, with limited treatment options. ...Toxic APAP exposure induces hepatic nuclear factor kappa B (NFkappaB) activation. ...
Acetaminophen (APAP) overdose results in high morbidity and mortality, with limited treatment options. ...Toxic APAP ex …
Acetaminophen Hepatotoxicity.
Ramachandran A, Jaeschke H. Ramachandran A, et al. Semin Liver Dis. 2019 May;39(2):221-234. doi: 10.1055/s-0039-1679919. Epub 2019 Mar 8. Semin Liver Dis. 2019. PMID: 30849782 Free PMC article.
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide. ...Importantly, most of the mechanisms have been confirmed in human hepatocytes and indirectly through biomarkers in plasma of APAP overdose patients. The extensive necrosis …
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide. ...Importantly, most of the mechanisms ha …
Paracetamol use during pregnancy - a call for precautionary action.
Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Bauer AZ, et al. Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23. Nat Rev Endocrinol. 2021. PMID: 34556849 Free PMC article. Review.
Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, includi …
Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medica …
Impact of acetaminophen on the efficacy of immunotherapy in cancer patients.
Bessede A, Marabelle A, Guégan JP, Danlos FX, Cousin S, Peyraud F, Chaput N, Spalato M, Roubaud G, Cabart M, Khettab M, Chaibi A, Rey C, Nafia I, Mahon FX, Soria JC, Italiano A. Bessede A, et al. Ann Oncol. 2022 Sep;33(9):909-915. doi: 10.1016/j.annonc.2022.05.010. Epub 2022 May 30. Ann Oncol. 2022. PMID: 35654248 Free article.
BACKGROUND: Acetaminophen (APAP) use has been associated with blunted vaccine immune responses. ...Hence, APAP should be used with caution in patients treated with ICB....
BACKGROUND: Acetaminophen (APAP) use has been associated with blunted vaccine immune responses. ...Hence, APAP should b …
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.
McGill MR, Hinson JA. McGill MR, et al. Drug Metab Rev. 2020 Nov;52(4):472-500. doi: 10.1080/03602532.2020.1832112. Epub 2020 Oct 14. Drug Metab Rev. 2020. PMID: 33103516 Free PMC article. Review.
Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market approximately 65 years ago. ...That work led to the introduction of N-acetylcysteine (NAC) as an antidote for APAP overdose. Subsequent studies identified the reactive metabolite …
Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market approximately 65 years ago. ...That work led t …
Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.
Pourbagher-Shahri AM, Schimmel J, Shirazi FM, Nakhaee S, Mehrpour O. Pourbagher-Shahri AM, et al. Toxicol Lett. 2022 Feb 1;355:47-61. doi: 10.1016/j.toxlet.2021.11.005. Epub 2021 Nov 14. Toxicol Lett. 2022. PMID: 34785186 Review.
INTRODUCTION: Acetaminophen (paracetamol, APAP) poisoning is a prominent global cause of drug-induced liver injury. ...The marginal clinical benefit of fomepizole adjunct therapy beyond NAC monotherapy remains to be clearly defined, and routine use for APAP o …
INTRODUCTION: Acetaminophen (paracetamol, APAP) poisoning is a prominent global cause of drug-induced liver injury. ...The mar …
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