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Showing results for arglabin
Your search for arglabine retrieved no results
Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19.
Manayi A, Nabavi SM, Khayatkashani M, Habtemariam S, Khayat Kashani HR. Manayi A, et al. Mol Biol Rep. 2021 Dec;48(12):8221-8225. doi: 10.1007/s11033-021-06827-7. Epub 2021 Oct 15. Mol Biol Rep. 2021. PMID: 34655016 Free PMC article. Review.
Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene gamma-lactone which was first isolated from Artemisia glabella. ...Since both NLRP3 inflammasome and cytokine storm are associated with the pathogenesis of COVID-19 and …
Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene gamma-lactone which was firs …
Arglabin: From isolation to antitumor evaluation.
Lone SH, Bhat KA, Khuroo MA. Lone SH, et al. Chem Biol Interact. 2015 Oct 5;240:180-98. doi: 10.1016/j.cbi.2015.08.015. Epub 2015 Aug 29. Chem Biol Interact. 2015. PMID: 26327249 Review.
Arglabin belongs to guaianolide class of sesquiterpene lactones, isolated from Artemisia species. The molecule bears a 5,7,5-tricyclic ring system having five contiguous stereo centers in which the two five membered rings are trans-annulated. Arglabin shows promisin …
Arglabin belongs to guaianolide class of sesquiterpene lactones, isolated from Artemisia species. The molecule bears a 5,7,5-tricycli …
Chemical modification of arglabin and biological activity of its new derivatives.
Adekenov SM. Adekenov SM. Fitoterapia. 2016 Apr;110:196-205. doi: 10.1016/j.fitote.2015.11.018. Epub 2015 Nov 25. Fitoterapia. 2016. PMID: 26625839 Review.
This review summarizes the results of own research on chemical modification of the molecule of sesquiterpene lactone arglabin from Artemisia glabella Kar. et Kir. Over 70 new arglabin derivatives were obtained which are polyfunctional compounds with oxy functions, a …
This review summarizes the results of own research on chemical modification of the molecule of sesquiterpene lactone arglabin from Ar …
Arglabin, an EGFR receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells.
El Gaafary M, Morad SAF, Schmiech M, Syrovets T, Simmet T. El Gaafary M, et al. Biomed Pharmacother. 2022 Dec;156:113873. doi: 10.1016/j.biopha.2022.113873. Epub 2022 Oct 19. Biomed Pharmacother. 2022. PMID: 36272260 Free article.
Evidence for clinical efficacy of a semisynthetic derivative of arglabin in anticancer treatment prompted us to examine molecular mechanisms and cellular targets of arglabin. ...Henceforth, arglabin inhibited the EGFR downstream signaling pathways mTORC1 and …
Evidence for clinical efficacy of a semisynthetic derivative of arglabin in anticancer treatment prompted us to examine molecular mec …
Analysis of arglabin and its derivatives using high-performance liquid chromatography.
Adekenov SM, Shamilova ST, Khabarov IA. Adekenov SM, et al. Phytochem Anal. 2021 Sep;32(5):780-784. doi: 10.1002/pca.3023. Epub 2021 Jan 6. Phytochem Anal. 2021. PMID: 33410214
Physicochemical characterisation of commercial anititumour drugs based on arglabin can be time-consuming and expensive; thus, high-performance liquid chromatography (HPLC) is an optimal method to identify arglabin and its derivatives. ...The influence of the dipole …
Physicochemical characterisation of commercial anititumour drugs based on arglabin can be time-consuming and expensive; thus, high-pe …
Arglabin regulates microglia polarization to relieve neuroinflammation in Alzheimer's disease.
Yang Y, Guo L, Wang J, Li W, Zhou X, Zhang C, Han C. Yang Y, et al. J Biochem Mol Toxicol. 2022 Jun;36(6):e23045. doi: 10.1002/jbt.23045. Epub 2022 Mar 15. J Biochem Mol Toxicol. 2022. PMID: 35289014
Arglabin (Arg) is a derivative of parthenolide. At present, there are few reports on the pharmacological effects and targets of Arg. ...
Arglabin (Arg) is a derivative of parthenolide. At present, there are few reports on the pharmacological effects and targets of Arg. …
Cytotoxicity and Antitumor Activity of Arglabin and its Derivatives.
Adekenov S, Spiwok V, Beutler J, Maslova O, Rakhimov K. Adekenov S, et al. Open Access Maced J Med Sci. 2023;11(B):412-420. doi: 10.3889/oamjms.2023.11114. Epub 2023 Feb 24. Open Access Maced J Med Sci. 2023. PMID: 38173466 Free PMC article.
One of the practically available sesquiterpene lactones is arglabin, which, as a renewable material, is used for the synthesis of new compounds. ...CONCLUSION: When studying the antitumor activity on 60 cell lines of tumor cells (NCI60), clonogenic cells of C6 rat glioma, …
One of the practically available sesquiterpene lactones is arglabin, which, as a renewable material, is used for the synthesis of new …
Arglabin: A mediator of inflammasome modulated and independent myocardial injury (PARA-AMI study).
Bisht K, Verma VK, Abdullah Z, Prajapati V, Rajiv N, Bhatia J, Ray R, Nag TC, Arya DS. Bisht K, et al. Eur J Pharmacol. 2024 May 5;970:176465. doi: 10.1016/j.ejphar.2024.176465. Epub 2024 Mar 11. Eur J Pharmacol. 2024. PMID: 38479722
BACKGROUND: Arglabin is a plant alkaloid (sesquiterpene lactone) that is used as an anticancer drug. ...The present study was designed to investigate the protective effects of arglabin on the myocardium. STUDY DESIGN: This study was designed to evaluate the effect o …
BACKGROUND: Arglabin is a plant alkaloid (sesquiterpene lactone) that is used as an anticancer drug. ...The present study was designe …
Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy.
Ren Z, Yu P, Li D, Li Z, Liao Y, Wang Y, Zhou B, Wang L. Ren Z, et al. Circulation. 2020 May 26;141(21):1704-1719. doi: 10.1161/CIRCULATIONAHA.119.043053. Epub 2020 Feb 26. Circulation. 2020. PMID: 32098504
Specifically, macrophage activation and subtype switching, a key event at middle-stage of cardiac hypertrophy, was successfully targeted by Dapagliflozin, a sodium glucose cotransporter 2 inhibitor, in clinical trials for patients with heart failure, as well as TD139 and Argla …
Specifically, macrophage activation and subtype switching, a key event at middle-stage of cardiac hypertrophy, was successfully targeted by …
Arglabin is a plant sesquiterpene lactone that exerts potent anticancer effects on human oral squamous cancer cells via mitochondrial apoptosis and downregulation of the mTOR/PI3K/Akt signaling pathway to inhibit tumor growth in vivo.
He W, Lai R, Lin Q, Huang Y, Wang L. He W, et al. J BUON. 2018 Nov-Dec;23(6):1679-1685. J BUON. 2018. PMID: 30610794 Free article.
RESULTS: Arglabin exhibited an IC50 of 10 M in OSCC cells and induced apoptosis by inhibiting MMP and enhancing intracellular ROS levels. DAPI and annexin V/PI staining indicated apoptosis of OSCC cells induced by arglabin. Arglabin also downregulated the exp …
RESULTS: Arglabin exhibited an IC50 of 10 M in OSCC cells and induced apoptosis by inhibiting MMP and enhancing intracellular ROS lev …
51 results