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873 results

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Page 1
Cryo-EM Structure of K(+)-Bound hERG Channel Complexed with the Blocker Astemizole.
Asai T, Adachi N, Moriya T, Oki H, Maru T, Kawasaki M, Suzuki K, Chen S, Ishii R, Yonemori K, Igaki S, Yasuda S, Ogasawara S, Senda T, Murata T. Asai T, et al. Structure. 2021 Mar 4;29(3):203-212.e4. doi: 10.1016/j.str.2020.12.007. Epub 2021 Jan 14. Structure. 2021. PMID: 33450182 Free article.
The structure suggested that astemizole inhibits potassium conduction by binding directly below the selectivity filter. Furthermore, we propose a possible binding model of astemizole to the hERG channel and provide insights into the unusual sensitivity of hERG to se …
The structure suggested that astemizole inhibits potassium conduction by binding directly below the selectivity filter. Furthermore, …
Astemizole: an old anti-histamine as a new promising anti-cancer drug.
García-Quiroz J, Camacho J. García-Quiroz J, et al. Anticancer Agents Med Chem. 2011 Mar;11(3):307-14. doi: 10.2174/187152011795347513. Anticancer Agents Med Chem. 2011. PMID: 21443504 Review.
We will also describe the side effects of astemizole and discuss proposals to overcome such effects in cancer patients. Finally, we will remark on the relevance of developing novel astemizole-related compounds....
We will also describe the side effects of astemizole and discuss proposals to overcome such effects in cancer patients. Finally, we w …
Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro.
Wang X, Lu J, Ge S, Hou Y, Hu T, Lv Y, Wang C, He H. Wang X, et al. Microb Pathog. 2021 Jul;156:104929. doi: 10.1016/j.micpath.2021.104929. Epub 2021 Apr 29. Microb Pathog. 2021. PMID: 33932547 Free PMC article.
We analysied the binding character of astemizole to ACE2 by molecular docking and surface plasmon resonance (SPR) assays and molecule docking, SARS-COV-2 spike pseudotype virus was also taken to investigate the suppression viropexis effect of astemizole. ...Thus …
We analysied the binding character of astemizole to ACE2 by molecular docking and surface plasmon resonance (SPR) assays and molecule …
Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy.
Richards DM, Brogden RN, Heel RC, Speight TM, Avery GS. Richards DM, et al. Drugs. 1984 Jul;28(1):38-61. doi: 10.2165/00003495-198428010-00003. Drugs. 1984. PMID: 6204835 Review.
Astemizole is an H1-histamine receptor antagonist with a long duration of action permitting once daily administration. ...Thus, astemizole offers a worthwhile improvement in side effect profile over 'traditional' H1-histamine receptor antagonists, especially in pati …
Astemizole is an H1-histamine receptor antagonist with a long duration of action permitting once daily administration. ...Thus, as …
Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses.
Zhang S, Zhao L, Guo M, Liu P, Li S, Xie W, Tian AL, Pol JG, Chen H, Pan H, Mao M, Li Y, Zitvogel L, Jin Y, Kepp O, Kroemer G. Zhang S, et al. J Immunother Cancer. 2023 Jul;11(7):e006785. doi: 10.1136/jitc-2023-006785. J Immunother Cancer. 2023. PMID: 37419511 Free PMC article.
In contrast, astemizole acts as a histamine H1 receptor (H1R1) antagonist to activate T cells in a non-specific, DC-independent fashion. Astemizole induced the production of IL-2 and interferon-gamma (IFN-gamma) by CD4(+) and CD8(+) T cells both in vitro and in vivo …
In contrast, astemizole acts as a histamine H1 receptor (H1R1) antagonist to activate T cells in a non-specific, DC-independent fashi …
Onset of action of astemizole.
Janssens MM, Caers LI. Janssens MM, et al. Int J Clin Pharmacol Res. 1991;11(5):219-29. Int J Clin Pharmacol Res. 1991. PMID: 1814843 Review.
Yet, pharmacokinetically, there are no reasons why astemizole should not act within the first hours after intake, since plasma levels of unchanged astemizole are maximal within 40 min and there is fast tissue distribution. ...In conclusion, astemizole results …
Yet, pharmacokinetically, there are no reasons why astemizole should not act within the first hours after intake, since plasma levels …
Astemizole-induced paresthesia.
Kaufman HS, Chang P, Chang G. Kaufman HS, et al. N Engl J Med. 1990 Sep 6;323(10):684. doi: 10.1056/NEJM199009063231016. N Engl J Med. 1990. PMID: 1974696 No abstract available.
Arrhythmias after astemizole overdose.
Heidemann SM, Sarnaik AP. Heidemann SM, et al. Pediatr Emerg Care. 1996 Apr;12(2):102-4. doi: 10.1097/00006565-199604000-00009. Pediatr Emerg Care. 1996. PMID: 8859918 Review.
Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient. We present two cases of astemizole poisoning, one with asystole followed by ventricular fibrillation occurring 11 hours after ingestion treated with …
Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient. We present two c …
Astemizole-associated urinary retention.
Lin AY, Zahtz G, Myssiorek D. Lin AY, et al. Otolaryngol Head Neck Surg. 1991 Jun;104(6):893-4. doi: 10.1177/019459989110400623. Otolaryngol Head Neck Surg. 1991. PMID: 1679231 No abstract available.
873 results

Searches related to "astemizole"