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Autotaxin and chronic inflammatory diseases.
Magkrioti C, Galaris A, Kanellopoulou P, Stylianaki EA, Kaffe E, Aidinis V. Magkrioti C, et al. J Autoimmun. 2019 Nov;104:102327. doi: 10.1016/j.jaut.2019.102327. Epub 2019 Aug 28. J Autoimmun. 2019. PMID: 31471142 Review.
Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids including blood. ...ATX expression was shown to be necessary for embryonic development, and ATX deficient embryos exhibit defective vascular homeostasis and aberrant neuronal syst …
Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids including blood. ...ATX expression was shown t …
Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
Ray R, Sinha S, Aidinis V, Rai V. Ray R, et al. Cell Rep. 2021 Mar 2;34(9):108809. doi: 10.1016/j.celrep.2021.108809. Cell Rep. 2021. PMID: 33657371 Free article.
Conditional ablation of Atx or its pharmacological inhibition impairs muscle repair. Mechanistically, we identify LPAR1 as the key receptor in Atx-LPA signaling. ...Intramuscular injections of Atx/LPA show muscle hypertrophy. In addition, the regulatory effec …
Conditional ablation of Atx or its pharmacological inhibition impairs muscle repair. Mechanistically, we identify LPAR1 as the key re …
Autotaxin in Pathophysiology and Pulmonary Fibrosis.
Ninou I, Magkrioti C, Aidinis V. Ninou I, et al. Front Med (Lausanne). 2018 Jun 13;5:180. doi: 10.3389/fmed.2018.00180. eCollection 2018. Front Med (Lausanne). 2018. PMID: 29951481 Free PMC article. Review.
In turn, LPA is a bioactive phospholipid autacoid, forming locally upon increased ATX levels and acting also locally through its receptors, likely guided by ATX's structural conformation and cell surface associations. Increased ATX activity levels have been d …
In turn, LPA is a bioactive phospholipid autacoid, forming locally upon increased ATX levels and acting also locally through its rece …
Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors.
Vrontaki E, Melagraki G, Kaffe E, Mavromoustakos T, Kokotos G, Aidinis V, Afantitis A. Vrontaki E, et al. Curr Med Chem. 2016;23(17):1708-24. doi: 10.2174/0929867323666160321122228. Curr Med Chem. 2016. PMID: 26997151 Review.
Autotaxin (ATX) has become an attractive target with a huge pharmacological and pharmacochemical interest in LPA-related diseases and to date many small organic molecules have been explored as potential ATX inhibitors. ...In this review article several deployed virt …
Autotaxin (ATX) has become an attractive target with a huge pharmacological and pharmacochemical interest in LPA-related diseases and …
Autotaxin in Breast Cancer: Role, Epigenetic Regulation and Clinical Implications.
Drosouni A, Panagopoulou M, Aidinis V, Chatzaki E. Drosouni A, et al. Cancers (Basel). 2022 Nov 4;14(21):5437. doi: 10.3390/cancers14215437. Cancers (Basel). 2022. PMID: 36358855 Free PMC article. Review.
Autotaxin (ATX), the protein product of Ectonucleotide Pyrophosphatase Phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D (lysoPLD) responsible for the extracellular production of lysophosphatidic acid (LPA). ATX-LPA pathway signaling participates in sev …
Autotaxin (ATX), the protein product of Ectonucleotide Pyrophosphatase Phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D …
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.
Ninou I, Kaffe E, Müller S, Budd DC, Stevenson CS, Ullmer C, Aidinis V. Ninou I, et al. Pulm Pharmacol Ther. 2018 Oct;52:32-40. doi: 10.1016/j.pupt.2018.08.003. Epub 2018 Sep 7. Pulm Pharmacol Ther. 2018. PMID: 30201409
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease with a dismal prognosis and a largely unknown etiology. Autotaxin (ATX) is a secreted lysophospholipase D, largely responsible for extracellular production of lysophosphatidic acid (LPA), a bioactive p …
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease with a dismal prognosis and a largely unknown etiology. Autotaxin ( …
Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.
Sevastou I, Kaffe E, Mouratis MA, Aidinis V. Sevastou I, et al. Biochim Biophys Acta. 2013 Jan;1831(1):42-60. doi: 10.1016/j.bbalip.2012.07.019. Epub 2012 Jul 31. Biochim Biophys Acta. 2013. PMID: 22867755 Review.
Enzymes that participate in LPC and LPA metabolism, such as the phospholipase A(2) superfamily (PLA(2)) and autotaxin (ATX, ENPP2), play central roles in regulating LPC and LPA levels and consequently their actions. ...
Enzymes that participate in LPC and LPA metabolism, such as the phospholipase A(2) superfamily (PLA(2)) and autotaxin (ATX, ENPP2), p …
Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer.
Kaffe E, Magkrioti C, Aidinis V. Kaffe E, et al. Cancers (Basel). 2019 Oct 23;11(11):1626. doi: 10.3390/cancers11111626. Cancers (Basel). 2019. PMID: 31652837 Free PMC article. Review.
It focuses on the role of ATX/LPA in NAFLD development and its progression to liver cancer as NAFLD has an increasing incidence which is associated with the increasing incidence of liver cancer. ...Therefore, ATX/LPA signaling appears as an attractive therapeutic ta …
It focuses on the role of ATX/LPA in NAFLD development and its progression to liver cancer as NAFLD has an increasing incidence which …
ENPP2 Methylation in Health and Cancer.
Panagopoulou M, Fanidis D, Aidinis V, Chatzaki E. Panagopoulou M, et al. Int J Mol Sci. 2021 Nov 4;22(21):11958. doi: 10.3390/ijms222111958. Int J Mol Sci. 2021. PMID: 34769391 Free PMC article.
Autotaxin (ATX) encoded by Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a key enzyme in Lysophosphatidic Acid (LPA) synthesis implicated in cancer. ...Collectively, our results corroborate that methylation is an active level of ATX expression regula …
Autotaxin (ATX) encoded by Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a key enzyme in Lysophosphatidic Acid (LPA) …
Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.
Matralis AN, Afantitis A, Aidinis V. Matralis AN, et al. Med Res Rev. 2019 May;39(3):976-1013. doi: 10.1002/med.21551. Epub 2018 Nov 21. Med Res Rev. 2019. PMID: 30462853 Review.
Several years after its isolation from melanoma cells, an increasing body of experimental evidence has established the involvement of Autotaxin (ATX) in the pathogenesis of several diseases. ATX, an extracellular enzyme responsible for the hydrolysis of lysophosphat …
Several years after its isolation from melanoma cells, an increasing body of experimental evidence has established the involvement of Autota …
36 results