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Showing results for azasterol
Your search for axastrol retrieved no results
Effects of an azasterol inhibitor of sterol 24-transmethylation on sterol biosynthesis and growth of Leishmania donovani promastigotes.
Haughan PA, Chance ML, Goad LJ. Haughan PA, et al. Biochem J. 1995 May 15;308 ( Pt 1)(Pt 1):31-8. doi: 10.1042/bj3080031. Biochem J. 1995. PMID: 7755579 Free PMC article.
Inhibition of growth increased gradually with azasterol concentrations up to 5 micrograms/ml; concentrations of azasterol exceeding 5 micrograms/ml were lethal. ...Transfer of the azasterol-treated cells to medium lacking azasterol resulted in a gradua …
Inhibition of growth increased gradually with azasterol concentrations up to 5 micrograms/ml; concentrations of azasterol exce …
Azasterol inhibition of delta 24-sterol methyltransferase in Saccharomyces cerevisiae.
Oehlschlager AC, Angus RH, Pierce AM, Pierce HD Jr, Srinivasan R. Oehlschlager AC, et al. Biochemistry. 1984 Jul 31;23(16):3582-9. doi: 10.1021/bi00311a003. Biochemistry. 1984. PMID: 6383468
The inhibition of the delta 24-sterol methyltransferase (24-SMT) of Saccharomyces cerevisiae by side-chain azasterols is related to their nuclear skeleton and side chain nitrogen position. ...Kinetic inhibition studies with partially purified 24-SMT and several azastero …
The inhibition of the delta 24-sterol methyltransferase (24-SMT) of Saccharomyces cerevisiae by side-chain azasterols is related to t …
Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.
Rodrigues JC, Attias M, Rodriguez C, Urbina JA, Souza Wd. Rodrigues JC, et al. Antimicrob Agents Chemother. 2002 Feb;46(2):487-99. doi: 10.1128/AAC.46.2.487-499.2002. Antimicrob Agents Chemother. 2002. PMID: 11796362 Free PMC article.
We report on the antiproliferative effects and the ultrastructural and biochemical alterations induced in vitro by 22,26-azasterol, a sterol Delta(24(25))-methyltransferase (24-SMT) inhibitor, on Leishmania amazonensis. When promastigotes and amastigotes were exposed to 10 …
We report on the antiproliferative effects and the ultrastructural and biochemical alterations induced in vitro by 22,26-azasterol, a …
Physiological effects of an antimycotic azasterol on cultures of Saccharomyces cerevisiae.
Hays PR, Neal WD, Parks LW. Hays PR, et al. Antimicrob Agents Chemother. 1977 Aug;12(2):185-91. doi: 10.1128/AAC.12.2.185. Antimicrob Agents Chemother. 1977. PMID: 332071 Free PMC article.
The yeast Saccharomyces cerevisiae has been studied during cultivation with a naturally occurring antimycotic azasterol. At very low concentrations (1.0 to 10.0 ng/ml), where growth retardation is not observed, an unusual sterol, ergosta-8,14-dien-3beta-ol, accumulates in …
The yeast Saccharomyces cerevisiae has been studied during cultivation with a naturally occurring antimycotic azasterol. At very low …
Physiological response of Saccharomyces cerevisiae to 15-azasterol-mediated growth inhibition.
Rodriguez RJ, Parks LW. Rodriguez RJ, et al. Antimicrob Agents Chemother. 1981 Aug;20(2):184-9. doi: 10.1128/AAC.20.2.184. Antimicrob Agents Chemother. 1981. PMID: 7025753 Free PMC article.
We studied 15-aza-24-methylene-8,14-cholestadiene-3 beta-ol (15-azasterol) inhibition of Saccharomyces cerevisiae growth. Exposure to sublethal concentrations of this drug caused S. cerevisiae cells to undergo a transient period of inhibition at midlog phase. ...After over …
We studied 15-aza-24-methylene-8,14-cholestadiene-3 beta-ol (15-azasterol) inhibition of Saccharomyces cerevisiae growth. Exposure to …
Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic.
Work EM, Ferraudi G, Kiefer L, Liu G, Grigalunas M, Bhardwaj A, Kaur R, Dempsey JM, Wüstner D, Helquist P, Wiest O. Work EM, et al. J Org Chem. 2021 Jan 15;86(2):1612-1621. doi: 10.1021/acs.joc.0c02460. Epub 2020 Dec 28. J Org Chem. 2021. PMID: 33369429 Free PMC article.
Of particular interest is the development of mimics of small molecules with important cellular function that allow the direct observation of their trafficking in a cell. To this end, a novel 15-azasterol has been designed and synthesized as a luminescent cholesterol mimic …
Of particular interest is the development of mimics of small molecules with important cellular function that allow the direct observation of …
Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.
Jiménez-Jiménez C, Carrero-Lérida J, Sealey-Cardona M, Ruiz Pérez LM, Urbina JA, González Pacanowska D. Jiménez-Jiménez C, et al. Mol Biochem Parasitol. 2008 Jul;160(1):52-9. doi: 10.1016/j.molbiopara.2008.03.010. Epub 2008 Apr 8. Mol Biochem Parasitol. 2008. PMID: 18485498
We also found in this study that cells overproducing the enzyme do not have increased resistance to the sterol methenyltransferase inhibitor 22, 26 azasterol....
We also found in this study that cells overproducing the enzyme do not have increased resistance to the sterol methenyltransferase inhibitor …
Relationship between antifungal activity and inhibition of sterol biosynthesis in miconazole, clotrimazole, and 15-azasterol.
Taylor FR, Rodriguez RJ, Parks LW. Taylor FR, et al. Antimicrob Agents Chemother. 1983 Apr;23(4):515-21. doi: 10.1128/AAC.23.4.515. Antimicrob Agents Chemother. 1983. PMID: 6344784 Free PMC article.
This agent inhibits the growth of wild-type S. cerevisiae but does not inhibit the growth of a strain that is defective in the removal of the C-14 methyl group of lanosterol and in the introduction of the 5,6 double bond. 15-Azasterol does not inhibit the growth of a stero …
This agent inhibits the growth of wild-type S. cerevisiae but does not inhibit the growth of a strain that is defective in the removal of th …
68 results