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The following term was not found in PubMed: Beroline
Page 1
Did you mean berberrubine OR berlin (198,846 results)?
The metabolism of berberine and its contribution to the pharmacological effects.
Wang K, Feng X, Chai L, Cao S, Qiu F. Wang K, et al. Drug Metab Rev. 2017 May;49(2):139-157. doi: 10.1080/03602532.2017.1306544. Epub 2017 Apr 3. Drug Metab Rev. 2017. PMID: 28290706 Review.
Active metabolites such as columbamine, berberrubine and demethyleneberberine also exhibit similar pharmacological effects by comparison with berberine, such as antioxidant, anti-inflammatory, antitumor, antimicrobial, hepatoprotective, neuroprotective, hypolipidemic and h …
Active metabolites such as columbamine, berberrubine and demethyleneberberine also exhibit similar pharmacological effects by compari …
Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.
He X, Cui J, Ma H, Abuduaini N, Huang Y, Tang L, Wang W, Zhang Y, Wang Y, Lu W, Feng B, Huang J. He X, et al. Biochem Pharmacol. 2023 Dec;218:115868. doi: 10.1016/j.bcp.2023.115868. Epub 2023 Oct 21. Biochem Pharmacol. 2023. PMID: 37871880
Besides, we also confirmed the interaction between berberrubine and IMPDH2. Of note, berberrubine treatment significantly impairs the growth of human CRC cells in a dose-dependent manner, which can be rescued by supplementing with guanosine. Furthermore, oral admini …
Besides, we also confirmed the interaction between berberrubine and IMPDH2. Of note, berberrubine treatment significantly impa …
Structure-yeast alpha-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates.
Nguyen DV, Hengphasatporn K, Danova A, Suroengrit A, Boonyasuppayakorn S, Fujiki R, Shigeta Y, Rungrotmongkol T, Chavasiri W. Nguyen DV, et al. Sci Rep. 2023 Nov 1;13(1):18865. doi: 10.1038/s41598-023-45116-0. Sci Rep. 2023. PMID: 37914757 Free PMC article.
Thirty-five 9-O-berberrubine carboxylate derivatives were synthesized and evaluated for yeast alpha-glucosidase inhibitory activity. All compounds demonstrated better inhibitory activities than the parent compounds berberine (BBR) and berberrubine (BBRB), and a posi …
Thirty-five 9-O-berberrubine carboxylate derivatives were synthesized and evaluated for yeast alpha-glucosidase inhibitory activity. …
Unraveling the enigma: Molecular mechanisms of berberrubine-induced nephrotoxicity reversed by its parent form berberine.
Rao J, Gao Q, Li N, Wang Y, Wang T, Wang K, Qiu F. Rao J, et al. Phytomedicine. 2024 Jul;129:155648. doi: 10.1016/j.phymed.2024.155648. Epub 2024 Apr 16. Phytomedicine. 2024. PMID: 38669970
More importantly, berberine reversed the berberrubine-reduced nephrotoxicity. The results indicated that the cPLA2 signalling pathway was highly involved in the nephrotoxicity induced by berberrubine. ...CONCLUSION: This study is the first to revel the opposite biol …
More importantly, berberine reversed the berberrubine-reduced nephrotoxicity. The results indicated that the cPLA2 signalling pathway …
Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine.
Kim SA, Kwon Y, Kim JH, Muller MT, Chung IK. Kim SA, et al. Biochemistry. 1998 Nov 17;37(46):16316-24. doi: 10.1021/bi9810961. Biochemistry. 1998. PMID: 9819224
Berberrubine, however, did not inhibit topoisomerase I at concentrations up to 240 microM. Cleavage sites induced by topoisomerase II in the presence of berberrubine and etoposide were mapped in DNA. Berberrubine induces DNA cleavage in a site-specific and co …
Berberrubine, however, did not inhibit topoisomerase I at concentrations up to 240 microM. Cleavage sites induced by topoisomerase II …
Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell line.
Cui HS, Hayasaka S, Zhang XY, Hayasaka Y, Chi ZL, Zheng LS. Cui HS, et al. Life Sci. 2006 Aug 1;79(10):949-56. doi: 10.1016/j.lfs.2006.05.004. Epub 2006 May 12. Life Sci. 2006. PMID: 16797033
ARPE-19 cells were cultured to confluence. Berberrubine and IL-1beta or TNF-alpha were added to the medium. IL-8 and MCP-1 protein concentrations were measured using enzyme-linked immunosorbent assay. ...Fluorescein was dense (215+/-42 or 170+/-24 arbitrary units, respecti …
ARPE-19 cells were cultured to confluence. Berberrubine and IL-1beta or TNF-alpha were added to the medium. IL-8 and MCP-1 protein co …
Pharmacokinetics in rats and tissue distribution in mouse of berberrubine by UPLC-MS/MS.
Wang X, Wang S, Ma J, Ye T, Lu M, Fan M, Deng M, Hu L, Gao Z. Wang X, et al. J Pharm Biomed Anal. 2015 Nov 10;115:368-74. doi: 10.1016/j.jpba.2015.07.031. Epub 2015 Jul 26. J Pharm Biomed Anal. 2015. PMID: 26279368
The method has also been successfully applied in pharmacokinetics and tissue distribution study of berberrubine. The absolute bioavailability of berberrubine was determined to be 31.6%. The results also show that berberrubine is rapidly absorbed and widely di …
The method has also been successfully applied in pharmacokinetics and tissue distribution study of berberrubine. The absolute bioavai …
Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Wang K, Qiao M, Chai L, Cao S, Feng X, Ding L, Qiu F. Wang K, et al. Fitoterapia. 2018 Jan;124:23-33. doi: 10.1016/j.fitote.2017.10.005. Epub 2017 Oct 7. Fitoterapia. 2018. PMID: 28993283
Plasma, bile, urine and feces samples were collected from rats after oral administration of berberrubine with a dose of 30.0mg/kg and analyzed to characterize the metabolites of berberrubine in vivo for the first time. ...The results indicated that demethylenation, …
Plasma, bile, urine and feces samples were collected from rats after oral administration of berberrubine with a dose of 30.0mg/kg and …
Berberine Metabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress and Mitochondrial Dysfunction.
Yang WL, Zhang CY, Ji WY, Zhao LL, Yang FY, Zhang L, Cao X. Yang WL, et al. Am J Chin Med. 2024;52(1):253-274. doi: 10.1142/S0192415X24500113. Epub 2024 Feb 8. Am J Chin Med. 2024. PMID: 38351702
Our results revealed that, out of six BBR metabolites, berberrubine (BBB) and palmatine (PMT) significantly increased the production and glucose-stimulated secretion of GLP-1 in GLUTag cells. ...
Our results revealed that, out of six BBR metabolites, berberrubine (BBB) and palmatine (PMT) significantly increased the production …
143 results