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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1982 2
1984 2
1985 3
1986 6
1987 5
1988 1
1989 3
1990 4
1991 5
1992 9
1993 5
1994 9
1995 18
1996 6
1997 12
1998 16
1999 8
2000 24
2001 25
2002 13
2003 20
2004 16
2005 13
2006 20
2007 16
2008 15
2009 15
2010 14
2011 16
2012 10
2013 12
2014 12
2015 16
2016 3
2017 7
2018 13
2019 8
2020 10
2021 7
2022 6
2023 7
2024 0

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403 results

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Page 1
The Role of Protein-L-isoaspartyl Methyltransferase (PIMT) in the Suppression of Toxicity of the Oligomeric Form of Aβ42, in Addition to the Inhibition of Its Fibrillization.
Chatterjee T, Das G, Chatterjee BK, Ghosh S, Chakrabarti P. Chatterjee T, et al. ACS Chem Neurosci. 2023 Aug 16;14(16):2888-2901. doi: 10.1021/acschemneuro.3c00281. Epub 2023 Aug 3. ACS Chem Neurosci. 2023. PMID: 37535852
Far-UV CD indicated a shift in the conformational feature of AbetaOs from the random coil to beta-sheet in the presence of PIMT. Binding of bis-ANS to different AbetaOs (obtained using different concentrations of Abeta42 monomer) indicated the correlation of size of …
Far-UV CD indicated a shift in the conformational feature of AbetaOs from the random coil to beta-sheet in the presence of PIMT. Binding of …
Real-time detection of mAb aggregates in an integrated downstream process.
São Pedro MN, Isaksson M, Gomis-Fons J, Eppink MHM, Nilsson B, Ottens M. São Pedro MN, et al. Biotechnol Bioeng. 2023 Oct;120(10):2989-3000. doi: 10.1002/bit.28466. Epub 2023 Jun 13. Biotechnol Bioeng. 2023. PMID: 37309984
A fluorescent dye (FD)-based miniaturized sensor has previously been developed: a zigzag microchannel which mixes two streams under 30 s. Bis-ANS and CCVJ, two established FDs, were employed in this micromixer to detect aggregation of the biopharmaceutical monoclona …
A fluorescent dye (FD)-based miniaturized sensor has previously been developed: a zigzag microchannel which mixes two streams under 30 s. …
Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates.
São Pedro MN, Eppink MHM, Ottens M. São Pedro MN, et al. Biotechnol Prog. 2023 May 10:e3355. doi: 10.1002/btpr.3355. Online ahead of print. Biotechnol Prog. 2023. PMID: 37161718
A zigzag microchannel, which provides 90% of mixing efficiency under 30 s, coupled to an UV-Vis detector, and using four FDs, was studied and validated. With different generated mAb aggregation samples, the FDs Bis-ANS and CCVJ were able to robustly detect from, at …
A zigzag microchannel, which provides 90% of mixing efficiency under 30 s, coupled to an UV-Vis detector, and using four FDs, was studied an …
Synthesis and Anti-Inflammatory Activity Evaluation of Benzoxazole Derivatives as New Myeloid Differentiation Protein 2 Inhibitors.
Bai H, Cao Z, Meng S, Ge R, Ban S, Zhang Y, Tang L, Li QS. Bai H, et al. Chem Biodivers. 2023 Jun;20(6):e202201145. doi: 10.1002/cbdv.202201145. Epub 2023 May 10. Chem Biodivers. 2023. PMID: 37080925
The compounds 3c, 3d and 3g demonstrated the greatest anti-inflammatory activity against IL-6 with IC(50) values of 10.140.08, 5.430.51 and 5.090.88 muM, respectively. Furthermore, the bis-ANS displacement assay revealed that these compounds competitively inhibited …
The compounds 3c, 3d and 3g demonstrated the greatest anti-inflammatory activity against IL-6 with IC(50) values of 10.140.08, 5.430.51 and …
All3048, a DnaJ III homolog of Anabaena sp. PCC7120 mediates heat shock response in E. coli and its N-terminus J-domain stimulates DnaK ATPase activity.
Sriwastaw S, Rai R, Raj A, Kesari V, Rai LC. Sriwastaw S, et al. Int J Biol Macromol. 2023 Apr 1;233:123563. doi: 10.1016/j.ijbiomac.2023.123563. Epub 2023 Feb 4. Int J Biol Macromol. 2023. PMID: 36746302
Conformational properties of All3048 and its truncated variants were assessed using bis ANS, guanidine hydrochloride and acrylamide quenching. All3048(1-95), All3048 and All3048(31-128) increased DnaK ATPase activity by 8.6, 8.2, and 2.5 fold, respectively. ...
Conformational properties of All3048 and its truncated variants were assessed using bis ANS, guanidine hydrochloride and acryl …
Immobilized Amyloid Hexamer Fragments to Map Active Sites of Amyloid-Targeting Chemicals.
Cho I, Yoon S, Park S, Hong SW, Cho E, Kim E, Kim HY, Kim Y. Cho I, et al. ACS Chem Neurosci. 2023 Jan 4;14(1):9-18. doi: 10.1021/acschemneuro.2c00449. Epub 2022 Nov 29. ACS Chem Neurosci. 2023. PMID: 36445044
To evaluate the mapping potential of the peptide plate, we tested previously reported fluorescent imaging agents (CRANAD-28, bis-ANS), aggregation inhibitors (curcumin, scyllo-inositol), and aggregate dissociators (necrostatin-1, sunitinib) targeting Abeta. ...
To evaluate the mapping potential of the peptide plate, we tested previously reported fluorescent imaging agents (CRANAD-28, bis-A …
Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity.
Figueira AJ, Moreira GG, Saavedra J, Cardoso I, Gomes CM. Figueira AJ, et al. J Mol Biol. 2022 Oct 15;434(19):167791. doi: 10.1016/j.jmb.2022.167791. Epub 2022 Aug 12. J Mol Biol. 2022. PMID: 35970403 Free article.
Structural analysis revealed that S100B tetramerization spawns a novel extended cleft accommodating an aggregation-prone surface that mediates interactions with monomeric Abeta client via hydrophobic interactions, as corroborated by Bis-ANS fluorescence and docking …
Structural analysis revealed that S100B tetramerization spawns a novel extended cleft accommodating an aggregation-prone surface that mediat …
Development of β-sheet structure in Aβ aggregation intermediates diminishes exposed hydrophobic surface area and enhances proinflammatory activity.
Dhami KB, Karki S, Parks A, Nichols CG, Nichols MR. Dhami KB, et al. Biochim Biophys Acta Proteins Proteom. 2022 Sep 1;1870(9):140817. doi: 10.1016/j.bbapap.2022.140817. Epub 2022 Jul 26. Biochim Biophys Acta Proteins Proteom. 2022. PMID: 35905824
Abeta oligomers possessed a more open structure with significant solvent exposure of hydrophobic domains as determined by tryptophan fluorescence and bis-ANS binding, respectively. The protofibril-selective antibody AbSL readily discerned conformational differences …
Abeta oligomers possessed a more open structure with significant solvent exposure of hydrophobic domains as determined by tryptophan fluores …
p53 TAD2 Domain (38-61) Forms Amyloid-like Aggregates in Isolation.
Gadhave K, Kapuganti SK, Mishra PM, Giri R. Gadhave K, et al. ACS Chem Neurosci. 2022 Aug 3;13(15):2281-2287. doi: 10.1021/acschemneuro.1c00860. Epub 2022 Jul 20. ACS Chem Neurosci. 2022. PMID: 35856925
The aggregates were generated in vitro under acidic pH conditions after in silico scoring for amyloidogenic tendency and characterized using dye-based assays (ThT and bis-ANS fluorescence), CD spectroscopy, and microscopy (scanning electron microscoy, transmission e …
The aggregates were generated in vitro under acidic pH conditions after in silico scoring for amyloidogenic tendency and characterized using …
The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro.
Datki Z, Balazs E, Galik B, Sinka R, Zeitler L, Bozso Z, Kalman J, Hortobagyi T, Galik-Olah Z. Datki Z, et al. Int J Biol Macromol. 2022 Mar 15;201:262-269. doi: 10.1016/j.ijbiomac.2021.12.184. Epub 2022 Jan 7. Int J Biol Macromol. 2022. PMID: 34999044 Free article.
The RIC has significant interacting, anti-aggregating and disaggregating effects on H-Abeta. To detect these experiments, Bis-ANS and Thioflavin T were applied during amyloid binding, two aggregation-specific functional fluorescent dyes with different molecular char …
The RIC has significant interacting, anti-aggregating and disaggregating effects on H-Abeta. To detect these experiments, Bis-ANS …
403 results