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Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?
Bisaglia M, Bubacco L. Bisaglia M, et al. Biomolecules. 2020 Jan 29;10(2):195. doi: 10.3390/biom10020195. Biomolecules. 2020. PMID: 32013126 Free PMC article. Review.
Alterations in copper homeostasis might have deleterious consequences, and several neurodegenerative disorders, including Parkinson's disease (PD), have been associated with impaired copper levels. ...Overall, the recent discoveries described in this review s …
Alterations in copper homeostasis might have deleterious consequences, and several neurodegenerative disorders, including Parkinson's …
Interaction between alpha-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease.
Bisaglia M, Tessari I, Mammi S, Bubacco L. Bisaglia M, et al. Neuromolecular Med. 2009;11(4):239-51. doi: 10.1007/s12017-009-8082-1. Neuromolecular Med. 2009. PMID: 19669606 Review.
Binding sites are present in the C-terminal region, and similar, low affinity (in the millimolar range) is exhibited toward many different metal ions, including copper and iron. A more complex scenario emerges for these latter metal ions, which are also able …
Binding sites are present in the C-terminal region, and similar, low affinity (in the millimolar range) is exhibited toward many different m …
Copper Binding and Redox Activity of alpha-Synuclein in Membrane-Like Environment.
Bacchella C, Camponeschi F, Kolkowska P, Kola A, Tessari I, Baratto MC, Bisaglia M, Monzani E, Bubacco L, Mangani S, Casella L, Dell'Acqua S, Valensin D. Bacchella C, et al. Biomolecules. 2023 Feb 3;13(2):287. doi: 10.3390/biom13020287. Biomolecules. 2023. PMID: 36830656 Free PMC article.
For these reasons, the ternary interaction between alphaSyn, copper, and membranes needs to be elucidated in detail. Here, we investigated the structural properties of copper-alphaSyn binding through NMR, EPR, and XAS analyses, with particular emphasis on copper …
For these reasons, the ternary interaction between alphaSyn, copper, and membranes needs to be elucidated in detail. Here, we investi …
DJ-1 is a copper chaperone acting on SOD1 activation.
Girotto S, Cendron L, Bisaglia M, Tessari I, Mammi S, Zanotti G, Bubacco L. Girotto S, et al. J Biol Chem. 2014 Apr 11;289(15):10887-10899. doi: 10.1074/jbc.M113.535112. Epub 2014 Feb 24. J Biol Chem. 2014. PMID: 24567322 Free PMC article.
To investigate the mechanisms underlying the antioxidative function of DJ-1 in relation to SOD1 activity, we investigated the ability of DJ-1 to bind copper ions. We structurally characterized a novel copper binding site involving Cys-106, and we investigated …
To investigate the mechanisms underlying the antioxidative function of DJ-1 in relation to SOD1 activity, we investigated the ability of DJ- …
Structural characterization of a high affinity mononuclear site in the copper(II)-alpha-synuclein complex.
Bortolus M, Bisaglia M, Zoleo A, Fittipaldi M, Benfatto M, Bubacco L, Maniero AL. Bortolus M, et al. J Am Chem Soc. 2010 Dec 29;132(51):18057-66. doi: 10.1021/ja103338n. Epub 2010 Dec 8. J Am Chem Soc. 2010. PMID: 21141829
Recent studies have shown that aS is a metal binding protein. Moreover, heavy metal ions, in particular divalent copper, accelerate the aggregation process of the protein. In this work, we investigated the high affinity binding mode of truncated aS (1-99) (aS99) wit …
Recent studies have shown that aS is a metal binding protein. Moreover, heavy metal ions, in particular divalent copper, accel …