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70 results

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Page 1
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake.
Parhiz H, Shuvaev VV, Pardi N, Khoshnejad M, Kiseleva RY, Brenner JS, Uhler T, Tuyishime S, Mui BL, Tam YK, Madden TD, Hope MJ, Weissman D, Muzykantov VR. Parhiz H, et al. Among authors: brenner js. J Control Release. 2018 Dec 10;291:106-115. doi: 10.1016/j.jconrel.2018.10.015. Epub 2018 Oct 15. J Control Release. 2018. PMID: 30336167 Free PMC article.
Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke.
Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Nong J, et al. Among authors: brenner js. Mol Ther. 2024 May 1;32(5):1344-1358. doi: 10.1016/j.ymthe.2024.03.004. Epub 2024 Mar 7. Mol Ther. 2024. PMID: 38454606 Free PMC article.
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.
Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Shuvaev VV, et al. Among authors: brenner js. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2409266122. doi: 10.1073/pnas.2409266122. Epub 2025 Jul 16. Proc Natl Acad Sci U S A. 2025. PMID: 40668829 Free PMC article.
The Nano-War Against Complement Proteins.
Wang Z, Brenner JS. Wang Z, et al. Among authors: brenner js. AAPS J. 2021 Sep 10;23(5):105. doi: 10.1208/s12248-021-00630-9. AAPS J. 2021. PMID: 34505951 Free PMC article. Review.
Nanomedicine to fight infectious disease.
Rubey KM, Brenner JS. Rubey KM, et al. Among authors: brenner js. Adv Drug Deliv Rev. 2021 Dec;179:113996. doi: 10.1016/j.addr.2021.113996. Epub 2021 Oct 8. Adv Drug Deliv Rev. 2021. PMID: 34634395 Free PMC article. Review.
Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Tursi NJ, Tiwari S, Bedanova N, Kannan T, Parzych E, Okba N, Liaw K, Sárközy A, Livingston C, Trullen MI, Gary EN, Vadovics M, Laenger N, Londregan J, Khan MS, Omo-Lamai S, Muramatsu H, Blatney K, Hojecki C, Machado V, Maricic I, Smith TRF, Humeau LM, Patel A, Kossenkov A, Brenner JS, Allman D, Krammer F, Pardi N, Weiner DB. Tursi NJ, et al. Among authors: brenner js. Cell Rep Med. 2025 Apr 15;6(4):102035. doi: 10.1016/j.xcrm.2025.102035. Epub 2025 Mar 21. Cell Rep Med. 2025. PMID: 40120578 Free PMC article.
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS. Omo-Lamai S, et al. Among authors: brenner js. Nat Nanotechnol. 2025 Sep;20(9):1285-1297. doi: 10.1038/s41565-025-01974-5. Epub 2025 Aug 11. Nat Nanotechnol. 2025. PMID: 40789922 Free PMC article.
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.
Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WCW, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D. Anchordoquy T, et al. Among authors: brenner js. ACS Nano. 2024 Jun 4;18(22):13983-13999. doi: 10.1021/acsnano.4c00182. Epub 2024 May 20. ACS Nano. 2024. PMID: 38767983 Free PMC article.
70 results