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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1971 3
1972 4
1973 2
1974 1
1975 3
1976 2
1977 1
1978 1
1980 2
1981 1
1982 3
1983 2
1984 7
1985 6
1986 1
1987 1
1988 3
1989 2
1991 5
1992 7
1993 2
1994 1
1995 1
1996 3
1997 5
1998 1
1999 6
2000 4
2001 3
2002 5
2004 3
2005 5
2006 3
2007 3
2008 1
2009 5
2010 1
2011 2
2012 2
2013 1
2014 2
2015 6
2016 3
2017 1
2018 4
2019 2
2020 4
2021 1
2022 3
2023 2
2024 1

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138 results

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Page 1
Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy Overview.
Kumaran N, Pennesi ME, Yang P, Trzupek KM, Schlechter C, Moore AT, Weleber RG, Michaelides M. Kumaran N, et al. 2018 Oct 4 [updated 2023 Mar 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2018 Oct 4 [updated 2023 Mar 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 30285347 Free Books & Documents. Review.
GOAL 4: Inform (when possible) medical management of LCA/EOSRD based on genetic cause. GOAL 5: Inform genetic counseling for LCA/EOSRD....
GOAL 4: Inform (when possible) medical management of LCA/EOSRD based on genetic cause. GOAL 5: Inform genetic counseling for LCA/EOSR …
Hypoxic augmentation: The tale of a strange contraction.
Vanhoutte PM, Leung SWS. Vanhoutte PM, et al. Basic Clin Pharmacol Toxicol. 2020 Aug;127(2):59-66. doi: 10.1111/bcpt.13295. Epub 2019 Jul 29. Basic Clin Pharmacol Toxicol. 2020. PMID: 31310708 Free article. Review.
Over the years, this phenomenon was extended to a number of arterial preparations of different species and revisited, from a mechanistic point of view, with the successive demonstration that it depends on calcium handling in the vascular smooth muscle cells, is endothelium …
Over the years, this phenomenon was extended to a number of arterial preparations of different species and revisited, from a mechanistic poi …
Vascular nitric oxide: Beyond eNOS.
Zhao Y, Vanhoutte PM, Leung SW. Zhao Y, et al. J Pharmacol Sci. 2015 Oct;129(2):83-94. doi: 10.1016/j.jphs.2015.09.002. Epub 2015 Sep 28. J Pharmacol Sci. 2015. PMID: 26499181 Free article. Review.
NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endopl …
NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cycli …
Role of excitation-contraction coupling in muscle fatigue.
Allen DG, Westerblad H, Lee JA, Lännergren J. Allen DG, et al. Sports Med. 1992 Feb;13(2):116-26. doi: 10.2165/00007256-199213020-00007. Sports Med. 1992. PMID: 1313991 Review.
At a cellular level the reduced force could be caused by: (a) reduced intracellular calcium release during activity; (b) reduced sensitivity of the myofilaments to calcium; or (c) reduced maximal force development. ...Thus the accumulation of phosphate and protons w …
At a cellular level the reduced force could be caused by: (a) reduced intracellular calcium release during activity; (b) reduced sens …
Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone.
Detremmerie C, Vanhoutte PM, Leung S. Detremmerie C, et al. Acta Pharm Sin B. 2017 Jul;7(4):401-408. doi: 10.1016/j.apsb.2017.06.003. Epub 2017 Jul 3. Acta Pharm Sin B. 2017. PMID: 28752025 Free PMC article. Review.
The endothelium-dependent augmentation it causes counterintuitively depends on biased activation of soluble guanylyl cyclase (sGC) producing inosine 3',5'-cyclic monophosphate (cyclic IMP) rather than guanosine 3',5'-cyclic monophosphate. ...The …
The endothelium-dependent augmentation it causes counterintuitively depends on biased activation of soluble guanylyl cyclase (sGC) producing …
Umami taste transduction mechanisms.
Kinnamon SC. Kinnamon SC. Am J Clin Nutr. 2009 Sep;90(3):753S-755S. doi: 10.3945/ajcn.2009.27462K. Epub 2009 Jul 1. Am J Clin Nutr. 2009. PMID: 19571214 Free PMC article. Review.
A characteristic feature of umami taste is its potentiation by 5'-ribonucleotides such as guanosine-5'-monophosphate and inosine 5'-monophosphate, which also elicit the umami taste on their own. ...
A characteristic feature of umami taste is its potentiation by 5'-ribonucleotides such as guanosine-5'-monophosphate an …
Nontoxic and Naturally Occurring Active Compounds as Potential Inhibitors of Biological Targets in Liriomyza trifolii.
Shamkh IM, Al-Majidi M, Shntaif AH, Deng Kai PT, Nh-Pham N, Rahman I, Hamza D, Khan MS, Elsharayidi MS, Salah ET, Haikal A, Omoniyi MA, Abdalrahman MA, Karpinski TM. Shamkh IM, et al. Int J Mol Sci. 2022 Oct 24;23(21):12791. doi: 10.3390/ijms232112791. Int J Mol Sci. 2022. PMID: 36361586 Free PMC article.
In this regard, molecular docking and molecular dynamics simulations have been extensively used to investigate insect gut proteases and the interactions of PIs for the development of resistance against insects. We, herein, report an in silico study of (disodium 5'-inosi …
In this regard, molecular docking and molecular dynamics simulations have been extensively used to investigate insect gut proteases and the …
Molecular mechanisms of new immunosuppressants.
Halloran PF. Halloran PF. Clin Transplant. 1996 Feb;10(1 Pt 2):118-23. Clin Transplant. 1996. PMID: 8680047 Review.
MMF and MZ act to inhibit de novo purine synthesis, by inhibition of inosine monophosphate dehydrogenase (IMPDH). They create a selective immunodeficiency in T and B lymphocytes. ...Neither is currently in clinical trials in transplantation. The new immunophilin-bin …
MMF and MZ act to inhibit de novo purine synthesis, by inhibition of inosine monophosphate dehydrogenase (IMPDH). They create …
Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad.
Gao Y, Chen Z, Leung SW, Vanhoutte PM. Gao Y, et al. J Cardiovasc Pharmacol. 2015 Jun;65(6):545-8. doi: 10.1097/FJC.0000000000000167. J Cardiovasc Pharmacol. 2015. PMID: 25264755 Free PMC article. Review.
This hypoxic response is accompanied by increases in the intracellular level of inosine 5'-triphosphate and in the synthesis of inosine 3',5'-cyclic monophosphate (cIMP) by soluble guanylyl cyclase. The administration of exogenous cIMP or ino …
This hypoxic response is accompanied by increases in the intracellular level of inosine 5'-triphosphate and in the synthesis o …
138 results