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Dimeric pyrrolidinoindoline-type alkaloids with melanogenesis inhibitory activity in flower buds of Chimonanthus praecox.
Morikawa T, Nakanishi Y, Ninomiya K, Matsuda H, Nakashima S, Miki H, Miyashita Y, Yoshikawa M, Hayakawa T, Muraoka O. Morikawa T, et al. J Nat Med. 2014 Jul;68(3):539-49. doi: 10.1007/s11418-014-0832-1. Epub 2014 Mar 26. J Nat Med. 2014. PMID: 24668298
Among them, (-)-chimonanthine (1, IC50 = 0.93 muM), (-)-folicanthine (2, 1.4 muM), and (-)-calycanthidine (3, 1.8 muM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. ...
Among them, (-)-chimonanthine (1, IC50 = 0.93 muM), (-)-folicanthine (2, 1.4 muM), and (-)-calycanthidine (3, 1.8 muM) showed potent …
[Discrimination and clinical value of plasma metabolomic profiles in multidrug resistant epithelial ovarian cancer].
Wu WJ, Wang Q, Zhang W, Li L. Wu WJ, et al. Zhonghua Zhong Liu Za Zhi. 2017 Dec 23;39(12):896-902. doi: 10.3760/cma.j.issn.0253-3766.2017.12.004. Zhonghua Zhong Liu Za Zhi. 2017. PMID: 29262505 Chinese.
Compared to the cisplatin sensitive group, cisplatin resistant group exhibited a specific metabolic trait characterized by upregulation of 1-Monopalmitin, Ricinoleic acid methyl ester, Polyoxyethylene (600) mono-ricinoleate/Glycidyl stearate and downregulation of Calycanthidin …
Compared to the cisplatin sensitive group, cisplatin resistant group exhibited a specific metabolic trait characterized by upregulation of 1 …
DART-HRMS allows the detection of toxic alkaloids in animal autopsy specimens and guides the selection of confirmatory methods in accidental plant poisoning.
Zacometti C, Tata A, Stella R, Leone S, Pallante I, Merenda M, Catania S, Pozzato N, Piro R. Zacometti C, et al. Anal Chim Acta. 2023 Jul 11;1264:341309. doi: 10.1016/j.aca.2023.341309. Epub 2023 May 3. Anal Chim Acta. 2023. PMID: 37230724
The DART-HRMS results showed abundant signals of the alkaloids calycanthine, folicanthidine and calycanthidine, both in the rumen content and at the liver level. The DART-HRMS phytochemical fingerprinting of detached Chimonanthus praecox seeds was also compared with those …
The DART-HRMS results showed abundant signals of the alkaloids calycanthine, folicanthidine and calycanthidine, both in the rumen con …
Application of diazene-directed fragment assembly to the total synthesis and stereochemical assignment of (+)-desmethyl-meso-chimonanthine and related heterodimeric alkaloids.
Lathrop SP, Movassaghi M. Lathrop SP, et al. Chem Sci. 2014 Jan 1;5(1):10.1039/C3SC52451E. doi: 10.1039/C3SC52451E. Chem Sci. 2014. PMID: 24409339 Free PMC article.
We describe the first application of our methodology for heterodimerization via diazene fragmentation towards the total synthesis of (-)-calycanthidine, meso-chimonanthine, and (+)-desmethyl-meso-chimonanthine. ...
We describe the first application of our methodology for heterodimerization via diazene fragmentation towards the total synthesis of (-)- …
[Chemical constituents from the seed of Chimonanthus praecox extracted by supercritical carbon dioxide].
Liu ZX, Liu ZX. Liu ZX, et al. Zhong Yao Cai. 2008 Jul;31(7):992-5. Zhong Yao Cai. 2008. PMID: 18973012 Chinese.
RESULTS: Through comparison with mass spectra database, 43 components were isolated and identified. The main components are Calycanathine (51.88%), Calycanthidine (11.43%), n-Pentatriacontene (11.49%), (E, E)-2,4-Decadienal (9.67%), 1,1-diethoxyethoxy-3, 7-dimethyl-2, 6-Oc …
RESULTS: Through comparison with mass spectra database, 43 components were isolated and identified. The main components are Calycanathine (5 …