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Clinical effects of a single dose of cannabinoids to patients with chronic lymphocytic leukemia.
Melén CM, Merrien M, Wasik AM, Panagiotidis G, Beck O, Sonnevi K, Junlén HR, Christensson B, Sander B, Wahlin BE. Melén CM, et al. Leuk Lymphoma. 2022 Jun;63(6):1387-1397. doi: 10.1080/10428194.2021.2020776. Epub 2022 Jan 17. Leuk Lymphoma. 2022. PMID: 35037561 Clinical Trial.
This phase II clinical trial investigates a one-time oromucosal dose of tetrahydrocannabinol/cannabidiol (THC/CBD) in 23 patients with indolent leukemic B cell lymphomas. Primary endpoint was a significant reduction in leukemic B cells. ...Based on this study, THC/C …
This phase II clinical trial investigates a one-time oromucosal dose of tetrahydrocannabinol/cannabidiol (THC/CBD) in 23 patients with indol …
2-Arachidonoylglycerol Modulates CXCL12-Mediated Chemotaxis in Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia.
Merrien M, Wasik AM, Melén CM, Morsy MHA, Sonnevi K, Junlén HR, Christensson B, Wahlin BE, Sander B. Merrien M, et al. Cancers (Basel). 2023 Mar 3;15(5):1585. doi: 10.3390/cancers15051585. Cancers (Basel). 2023. PMID: 36900374 Free PMC article.
The biolipid 2-arachidonoylglycerol (2-AG), an agonist for the cannabinoid receptors CB1 and CB2, is released by stromal cells in the bone marrow. To investigate the role of 2-AG in lymphoma, we analyzed the chemotactic response of primary B-cell lymphoma cel …
The biolipid 2-arachidonoylglycerol (2-AG), an agonist for the cannabinoid receptors CB1 and CB2, is released by stromal cells in the …
Cannabinoid receptors expression in bone marrow trephine biopsy of chronic lymphocytic leukaemia patients treated with purine analogues.
Piszcz JA, Lemancewicz D, Kloczko J, Dzieciol J, Rusak M, Dabrowska M. Piszcz JA, et al. Exp Oncol. 2007 Sep;29(3):221-5. Exp Oncol. 2007. PMID: 18004250
B-cell chronic lymphocytic leukaemia is one of the diseases in which these processes are altered. ...CONCLUSION: The study provides original evidence for the existence of cannabinoid receptors on B-lymphocytes in chronic lymphoc …
B-cell chronic lymphocytic leukaemia is one of the diseases in which these processes are altered. ...CONC …
Validating the anti-lymphoma pharmacodynamic actions of the endocannabinoids on canine non-Hodgkin lymphoma.
Omer S, Pathak S, Nadar R, Bowen D, Sandey M, Dhanasekaran M, Pondugula S, Mansour M, Boothe D. Omer S, et al. Life Sci. 2023 Aug 15;327:121862. doi: 10.1016/j.lfs.2023.121862. Epub 2023 Jun 15. Life Sci. 2023. PMID: 37330042
There was a significantly higher expression of CB(1) and CB(2) receptors in B-cell lymphoma (BCL) cells (1771, CLBL-1, Ramos) compared to canine T-cell lymphoma (TCL) cells (CL-1). ...SIGNIFICANCE: Establishing the anti-lymphoma pharmacodynamic actions of endocannab …
There was a significantly higher expression of CB(1) and CB(2) receptors in B-cell lymphoma (BCL) cells (1771, CLBL-1, Ramos) …
Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation.
Freund P, Porpaczy EA, Le T, Gruber M, Pausz C, Staber P, Jäger U, Vanura K. Freund P, et al. PLoS One. 2016 Jun 1;11(6):e0156693. doi: 10.1371/journal.pone.0156693. eCollection 2016. PLoS One. 2016. PMID: 27248492 Free PMC article.
The cannabinoid receptors 1 and 2 (CNR1&2) are overexpressed in a variety of malignant diseases and cannabinoids can have noteworthy impact on tumor cell viability and tumor growth. Patients diagnosed with chronic lymphocytic leukemia (CLL) …
The cannabinoid receptors 1 and 2 (CNR1&2) are overexpressed in a variety of malignant diseases and cannabinoids can have …
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation.
Gustafsson K, Wang X, Severa D, Eriksson M, Kimby E, Merup M, Christensson B, Flygare J, Sander B. Gustafsson K, et al. Int J Cancer. 2008 Sep 1;123(5):1025-33. doi: 10.1002/ijc.23584. Int J Cancer. 2008. PMID: 18546271 Free article.
In this study, we evaluated the expression of cannabinoid receptors type 1 and type 2 (CB1 and CB2) in non-Hodgkin lymphomas of B cell type (n = 62). ...In functional studies using MCL, Burkitt lymphoma (BL), chronic lymphatic leukemia (CLL) and …
In this study, we evaluated the expression of cannabinoid receptors type 1 and type 2 (CB1 and CB2) in non-Hodgkin lymphomas of B …