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Neuroprotective Herbs for the Management of Alzheimer's Disease.
Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. Gregory J, et al. Biomolecules. 2021 Apr 8;11(4):543. doi: 10.3390/biom11040543. Biomolecules. 2021. PMID: 33917843 Free PMC article. Review.
Background-Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease that is characterized by memory loss, personality changes, and a decline in cognitive function. ...Methods-This article systematically reviews recent studie …
Background-Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease that is characte …
The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.
Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, Tanzi RE, Larsen L. Snow AD, et al. Sci Rep. 2019 Feb 6;9(1):561. doi: 10.1038/s41598-019-38645-0. Sci Rep. 2019. PMID: 30728442 Free PMC article.
PTI-00703 cat's claw demonstrated both the ability to prevent formation/aggregation and disaggregate preformed Abeta fibrils (1-42 and 1-40) and tau protein tangles/filaments. ...The discovery of a natural plant extract from the Amazon rain forest plant (i.e. …
PTI-00703 cat's claw demonstrated both the ability to prevent formation/aggregation and disaggregate preformed Abeta fi …
Fiber diffraction as a screen for amyloid inhibitors.
Kirschner DA, Gross AA, Hidalgo MM, Inouye H, Gleason KA, Abdelsayed GA, Castillo GM, Snow AD, Pozo-Ramajo A, Petty SA, Decatur SM. Kirschner DA, et al. Curr Alzheimer Res. 2008 Jun;5(3):288-307. doi: 10.2174/156720508784533295. Curr Alzheimer Res. 2008. PMID: 18537544
Targeting the initial formation of amyloid assemblies is a preferred approach to therapeutic intervention in amyloidoses, which include such diseases as Alzheimer's, Parkinson's, Huntington's, etc., as the early-stage, oligomers that form before the development of b …
Targeting the initial formation of amyloid assemblies is a preferred approach to therapeutic intervention in amyloidoses, which include such …
Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40).
Frackowiak T, Baczek T, Roman K, Zbikowska B, Gleńsk M, Fecka I, Cisowski W. Frackowiak T, et al. Z Naturforsch C J Biosci. 2006 Nov-Dec;61(11-12):821-6. doi: 10.1515/znc-2006-11-1209. Z Naturforsch C J Biosci. 2006. PMID: 17294693 Free article.
These results are discussed and interpreted in the view of developing a strategy for identification of novel compounds of great importance in Alzheimer disease therapy....
These results are discussed and interpreted in the view of developing a strategy for identification of novel compounds of great importance i …